Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression W Li, J Llopis, M Whitney, G Zlokarnik, RY Tsien Nature 392 (6679), 936-941, 1998 | 1041 | 1998 |
Quantitation of transcription and clonal selection of single living cells with β-lactamase as reporter G Zlokarnik, PA Negulescu, TE Knapp, L Mere, N Burres, L Feng, ... Science 279 (5347), 84-88, 1998 | 875 | 1998 |
Fluorescent peptides highlight peripheral nerves during surgery in mice MA Whitney, JL Crisp, LT Nguyen, B Friedman, LA Gross, P Steinbach, ... Nature biotechnology 29 (4), 352-356, 2011 | 241 | 2011 |
Diverse small-molecule modulators of SMN expression found by high-throughput compound screening: early leads towards a therapeutic for spinal muscular atrophy J Jarecki, X Chen, A Bernardino, DD Coovert, M Whitney, A Burghes, ... Human molecular genetics 14 (14), 2003-2018, 2005 | 174 | 2005 |
Thrombin activity associated with neuronal damage during acute focal ischemia B Chen, B Friedman, MA Whitney, JA Van Winkle, IF Lei, ES Olson, ... Journal of Neuroscience 32 (22), 7622-7631, 2012 | 135 | 2012 |
Host cell factor requirement for hepatitis C virus enzyme maturation L Waxman, M Whitney, BA Pollok, LC Kuo, PL Darke Proceedings of the National Academy of Sciences 98 (24), 13931-13935, 2001 | 129 | 2001 |
Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation M Whitney, EN Savariar, B Friedman, RA Levin, JL Crisp, HL Glasgow, ... Angewandte Chemie (International ed. in English) 52 (1), 325, 2013 | 122 | 2013 |
Dual Targeting of Integrin αvβ3 and Matrix Metalloproteinase-2 for Optical Imaging of Tumors and Chemotherapeutic Delivery JL Crisp, EN Savariar, HL Glasgow, LG Ellies, MA Whitney, RY Tsien Molecular cancer therapeutics 13 (6), 1514-1525, 2014 | 112 | 2014 |
A ubiquitin-based tagging system for controlled modulation of protein stability JH Stack, M Whitney, SM Rodems, BA Pollok Nature biotechnology 18 (12), 1298-1302, 2000 | 111 | 2000 |
Early detection of thrombin activity in neuroinflammatory disease D Davalos, KM Baeten, MA Whitney, ES Mullins, B Friedman, ES Olson, ... Annals of neurology 75 (2), 303-308, 2014 | 105 | 2014 |
In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity ES Olson, MA Whitney, B Friedman, TA Aguilera, JL Crisp, FM Baik, ... Integrative biology 4 (6), 595-605, 2012 | 96 | 2012 |
Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize SR Adams, HC Yang, EN Savariar, J Aguilera, JL Crisp, KA Jones, ... Nature communications 7 (1), 13019, 2016 | 59 | 2016 |
Peptides whose uptake by cells is controllable T Jiang, E Olsen, M Whitney, T Aguilera, Q Nguyen, E Wong, R Tsien US Patent App. 11/437,095, 2007 | 59 | 2007 |
Nerve-targeted probes for fluorescence-guided intraoperative imaging DV Hingorani, MA Whitney, B Friedman, JK Kwon, JL Crisp, Q Xiong, ... Theranostics 8 (15), 4226, 2018 | 57 | 2018 |
Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities MA Whitney US Patent 5,928,888, 1999 | 50 | 1999 |
Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage DV Hingorani, CN Lippert, JL Crisp, EN Savariar, JPC Hasselmann, ... PloS one 13 (9), e0198464, 2018 | 48 | 2018 |
Improved facial nerve identification with novel fluorescently labeled probe AP Wu, MA Whitney, JL Crisp, B Friedman, RY Tsien, QT Nguyen The Laryngoscope 121 (4), 805-810, 2011 | 43 | 2011 |
Peptides whose uptake by cells is controllable T Jiang, ES Olson, M Whitney, R Tsien US Patent 7,985,401, 2011 | 40 | 2011 |
Matrix-Metalloproteinases in head and neck carcinoma–cancer genome atlas analysis and fluorescence imaging in mice SJ Hauff, SC Raju, RK Orosco, AM Gross, JA Diaz-Perez, E Savariar, ... Otolaryngology–Head and Neck Surgery 151 (4), 612-618, 2014 | 39 | 2014 |
Peptides and aptamers for targeting of neuron or nerves RY Tsien, QT Nguyen, M Whitney US Patent 8,685,372, 2014 | 39 | 2014 |