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Colin KW Lim
Colin KW Lim
Dirección de correo verificada de illinois.edu
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Treatment of a mouse model of ALS by in vivo base editing
CKW Lim, M Gapinske, AK Brooks, WS Woods, JE Powell, J Winter, ...
Molecular Therapy 28 (4), 1177-1189, 2020
1622020
Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies
CH Lo, CKW Lim, Z Ding, SP Wickramasinghe, AR Braun, KH Ashe, ...
Alzheimer's & Dementia 15 (11), 1489-1502, 2019
582019
Targeted gene silencing in the nervous system with CRISPR-Cas13
JE Powell, CKW Lim, R Krishnan, TX McCallister, C Saporito-Magriña, ...
Science advances 8 (3), eabk2485, 2022
492022
Noncompetitive inhibitors of TNFR1 probe conformational activation states
CH Lo, TM Schaaf, BD Grant, CKW Lim, P Bawaskar, CC Aldrich, ...
Science signaling 12 (592), eaav5637, 2019
492019
Discovery of small molecule inhibitors of huntingtin exon 1 aggregation by FRET-based high-throughput screening in living cells
CH Lo, NK Pandey, CKW Lim, Z Ding, M Tao, DD Thomas, R Langen, ...
ACS Chemical Neuroscience 11 (15), 2286-2295, 2020
232020
CRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes
CKW Lim, TX McCallister, C Saporito-Magriña, GD McPheron, R Krishnan, ...
Molecular Therapy 30 (12), 3619-3631, 2022
112022
Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors
CKW Lim, AJ Miskalis, P Perez-Pinera, T Gaj
Base Editors: Methods and Protocols, 135-158, 2023
22023
Treatment of a Mouse Model of ALS by CRISPR Base Editing
CKW Lim, M Gapinske, AK Brooks, WS Woods, JE Powell, AC Zeballos, ...
MOLECULAR THERAPY 28 (4), 406-406, 2020
22020
A novel small molecule screening platform for disrupting toxic tau oligomers in cells
CH Lo, CKW Lim, Z Ding, S Wickramasinghe, AR Braun, E Rhoades, ...
bioRxiv, 510412, 2019
22019
A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD
TX McCallister, CKW Lim, WM Terpstra, S Zhang, JE Powell, T Gaj
bioRxiv, 2023.12. 12.571328, 2023
2023
CRISPR base editing of cis-regulatory elements enables target gene perturbations
CKW Lim, TX McCallister, C Saporito-Magriña, GD McPheron, R Krishnan, ...
bioRxiv, 2022.05. 26.493649, 2022
2022
Targeted Gene Knockdown in the Brain and Spinal Cord by CRISPR-Cas13
CKW Lim, JE Powell, R Krishnan, TX McCallister, C Saporito-Magrina, ...
MOLECULAR THERAPY 30 (4), 300-300, 2022
2022
Lowering Huntingtin Gene Expression by Targeted Base Editing of Cis-Regulatory Elements in its Promoter Sequence
TX McCallister, CKW Lim, C Saporito-Magrina, R Krishnan, GD McPheron, ...
MOLECULAR THERAPY 30 (4), 390-390, 2022
2022
Development of Platforms to Target HTT In Vivo Using Base Editing Technologies
S Shirguppe, M Gapinske, D Swami, P Acharya, D Anand, D Joulani, ...
MOLECULAR THERAPY 30 (4), 298-298, 2022
2022
Genome Editing and CRISPR Technology
CKW Lim, T Gaj
Encyclopedia of Cell Biology: Volume 1-6, Second Edition, 650-656, 2022
2022
Manipulation of Tau Oligomerization and Aggregation Characterized by Time-Resolved FRET
CH Lo, T Schaaf, B Grant, CKW Lim, D Thomas, J Sachs
Biophysical Journal 114 (3), 585a-586a, 2018
2018
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