Xavier Gómez-Santacana
Xavier Gómez-Santacana
Institut de Génomique Fonctionnelle - CNRS
Verified email at igf.cnrs.fr
TitleCited byYear
An allosteric modulator to control endogenous G protein-coupled receptors with light
S Pittolo, X Gómez-Santacana, K Eckelt, X Rovira, J Dalton, C Goudet, ...
Nature chemical biology 10 (10), 813, 2014
802014
Illuminating phenylazopyridines to photoswitch metabotropic glutamate receptors: from the flask to the animals
X Gómez-Santacana, S Pittolo, X Rovira, M Lopez, C Zussy, JAR Dalton, ...
ACS central science 3 (1), 81-91, 2016
232016
Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in) activation
JAR Dalton, X Gómez-Santacana, A Llebaria, J Giraldo
Journal of chemical information and modeling 54 (5), 1476-1487, 2014
182014
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, ...
Molecular psychiatry 23 (3), 509, 2018
172018
Shining light on an mGlu5 photoswitchable NAM: a theoretical perspective
J AR Dalton, I Lans, X Rovira, F Malhaire, X Gómez-Santacana, S Pittolo, ...
Current neuropharmacology 14 (5), 441-454, 2016
102016
A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5
X Gomez-Santacana, X Rovira, JA Dalton, C Goudet, JP Pin, P Gorostiza, ...
MedChemComm 5 (10), 1548-1554, 2014
82014
Photoswitching the Efficacy of a Small‐Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism
X Gómez‐Santacana, SM de Munnik, P Vijayachandran, ...
Angewandte Chemie 130 (36), 11782-11786, 2018
42018
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation
X Gómez-Santacana, JAR Dalton, X Rovira, JP Pin, C Goudet, ...
European journal of medicinal chemistry 127, 567-576, 2017
42017
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
C Zussy, X Gomez-Santacana, X Rovira, D De Bundel, S Ferrazo, ...
FUNDAMENTAL & CLINICAL PHARMACOLOGY 31, 59-59, 2017
12017
A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light
X Gómez-Santacana, SM de Munnik, TAM Mocking, NJ Hauwert, S Sun, ...
Beilstein Archives 2019 (1), 69, 2019
2019
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
S Pittolo, H Lee, A Lladó, S Tosi, M Bosch, L Bardia, X Gómez-Santacana, ...
Proceedings of the National Academy of Sciences, 201900430, 2019
2019
Optical activation of endogenous metabotropic glutamate receptor 4 (mGlu4) in the amygdala dynamically regulates symptoms associated with persistent …
C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, ...
Molecular psychiatry 23 (3), 489, 2018
2018
Design, synthesis and characterisation of photoswitchable allosteric modulators of metabotropic glutamate receptors
X Gómez Santacana
Universitat de Barcelona, 2016
2016
Optopharmacological control of endogenous g protein-coupled receptors
C Goudet, C Zussy, S Pittollo, X Gomez-Santacana, K Eckelt, X Rovira, ...
Journal of Neurochemistry 134, 2015
2015
Glutamate receptor photomodulators
A Llebaria, P Gorostiza, X Gómez-Santacana, S Pittolo, J Giraldo, ...
2015
Optical Control of Metabotropic Glutamate Receptor with Photoswitchable Drugs
S Pittolo, X Gomez-Santacana, K Eckelt, X Rovira, J Dalton, C Goudet, ...
CURRENT NEUROPHARMACOLOGY 12, 52-52, 2014
2014
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Articles 1–16