| Three-component cycloadditions: the first transition metal-catalyzed [5+ 2+ 1] cycloaddition reactions PA Wender, GG Gamber, RD Hubbard, L Zhang Journal of the American Chemical Society 124 (12), 2876-2877, 2002 | 192 | 2002 |
| Multicomponent cycloadditions: The four-component [5+ 1+ 2+ 1] cycloaddition of vinylcyclopropanes, alkynes, and CO PA Wender, GG Gamber, RD Hubbard, SM Pham, L Zhang Journal of the American Chemical Society 127 (9), 2836-2837, 2005 | 169 | 2005 |
| Toward the ideal synthesis. New transition metal-catalyzed reactions inspired by novel medicinal leads PA Wender, FC Bi, GG Gamber, F Gosselin, RD Hubbard, MJC Scanio, ... Pure and applied chemistry 74 (1), 25-31, 2002 | 140 | 2002 |
| Total synthesis of (−)-laulimalide PA Wender, SG Hegde, RD Hubbard, L Zhang Journal of the American Chemical Society 124 (18), 4956-4957, 2002 | 132 | 2002 |
| Microtubule-stabilizing agents based on designed laulimalide analogues SL Mooberry, DA Randall-Hlubek, RM Leal, SG Hegde, RD Hubbard, ... Proceedings of the National Academy of Sciences 101 (23), 8803-8808, 2004 | 94 | 2004 |
| Highly Substituted t er-Cyclopentanes as Receptors for Lipid A RD Hubbard, SR Horner, BL Miller Journal of the American Chemical Society 123 (24), 5810-5811, 2001 | 90 | 2001 |
| Cationic Lipids and Uses Thereof PA Dande, TM Hansen, RD Hubbard, CK Wada, L Tian, X Zhao US Patent App. 12/425,254, 2009 | 83 | 2009 |
| Substituted pyrazolo [3, 4-d] pyrimidines as protein kinase inhibitors GS Sheppard, GT Wang, F Palazzo, RL Bell, RA Mantei, J Wang, ... US Patent 7,772,231, 2010 | 79 | 2010 |
| Fragment-based, structure-enabled discovery of novel pyridones and pyridone macrocycles as potent bromodomain and extra-terminal domain (BET) family bromodomain inhibitors L Wang, JK Pratt, T Soltwedel, GS Sheppard, SD Fidanze, D Liu, ... Journal of medicinal chemistry 60 (9), 3828-3850, 2017 | 71 | 2017 |
| Synthesis and biological evaluation of (−)-laulimalide analogues PA Wender, SG Hegde, RD Hubbard, L Zhang, SL Mooberry Organic Letters 5 (19), 3507-3509, 2003 | 64 | 2003 |
| Imidazo [2, 1-b] thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases SD Fidanze, SA Erickson, GT Wang, R Mantei, RF Clark, BK Sorensen, ... Bioorganic & medicinal chemistry letters 20 (8), 2452-2455, 2010 | 63 | 2010 |
| Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors AG Waterson, KG Petrov, KR Hornberger, RD Hubbard, DM Sammond, ... Bioorganic & Medicinal Chemistry Letters 19 (5), 1332-1336, 2009 | 61 | 2009 |
| Pyridinone and pyridazinone derivatives RD Hubbard, L Wang, CH Park, C Sun, KF McDaniel, JK Pratt, ... US Patent 9,561,231, 2017 | 50 | 2017 |
| Substituted 4-amino-1H-pyrazolo [3, 4-d] pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases GT Wang, RA Mantei, RD Hubbard, JL Wilsbacher, Q Zhang, L Tucker, ... Bioorganic & medicinal chemistry letters 20 (20), 6067-6071, 2010 | 48 | 2010 |
| Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno [3, 2-d] pyrimidines RD Hubbard, SH Dickerson, HK Emerson, RJ Griffin, MJ Reno, ... Bioorganic & medicinal chemistry letters 18 (21), 5738-5740, 2008 | 47 | 2008 |
| Polyethylene glycol lipid conjugates and uses thereof PA Dande, TM Hansen, RD Hubbard, WE Kohlbrenner, L Li, AV Sarthy, ... US Patent App. 12/556,886, 2010 | 33 | 2010 |
| Cationic lipids and uses thereof PA Dande, TM Hansen, RD Hubbard, CK Wada, L Tian, X Zhao US Patent App. 12/425,198, 2009 | 33 | 2009 |
| Pyrazolo [3, 4-d] pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR) RD Hubbard, NY Bamaung, F Palazzo, Q Zhang, P Kovar, DJ Osterling, ... Bioorganic & medicinal chemistry letters 17 (19), 5406-5409, 2007 | 32 | 2007 |
| Developing lipid nanoparticle-based siRNA therapeutics for hepatocellular carcinoma using an integrated approach L Li, R Wang, D Wilcox, A Sarthy, X Lin, X Huang, L Tian, P Dande, ... Molecular cancer therapeutics 12 (11), 2308-2318, 2013 | 31 | 2013 |
| Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno [3, 2-d] pyrimidines as EGFR and ErbB-2 inhibitors KL Stevens, KJ Alligood, JGB Alberti, TR Caferro, SD Chamberlain, ... Bioorganic & Medicinal Chemistry Letters 19 (1), 21-26, 2009 | 27 | 2009 |
