Hanna-Kirsti S. Leiros
Hanna-Kirsti S. Leiros
Research scientist at UiT The Arctic University
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Cold adapted enzymes.
AO Smalås, HK Leiros, V Os, NP Willassen
Biotechnology annual review 6, 1-57, 2000
2252000
Specific radiation damage can be used to solve macromolecular crystal structures
RBG Ravelli, HKS Leiros, B Pan, M Caffrey, S McSweeney
Structure 11 (2), 217-224, 2003
1672003
Structural comparison of psychrophilic and mesophilic trypsins: Elucidating the molecular basis of cold‐adaptation
HK Schrøder Leiros, NP Willassen, AO Smalås
European Journal of Biochemistry 267 (4), 1039-1049, 2000
1072000
Trypsin specificity as elucidated by LIE calculations, X‐ray structures, and association constant measurements
HKS Leiros, BO Brandsdal, OA Andersen, V Os, I Leiros, R Helland, ...
Protein science 13 (4), 1056-1070, 2004
962004
The structure of bovine lysosomal α-mannosidase suggests a novel mechanism for low-pH activation
P Heikinheimo, R Helland, HKS Leiros, I Leiros, S Karlsen, G Evjen, ...
Journal of molecular biology 327 (3), 631-644, 2003
842003
Atomic resolution structures of trypsin provide insight into structural radiation damage
HKS Leiros, SM McSweeney, AO Smalås
Acta Crystallographica Section D: Biological Crystallography 57 (4), 488-497, 2001
802001
Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high …
AE Fedøy, N Yang, A Martinez, HKS Leiros, IH Steen
Journal of molecular biology 372 (1), 130-149, 2007
792007
Structural basis of 5-nitroimidazole antibiotic resistance the crystal structure of NimA from Deinococcus radiodurans
HKS Leiros, S Kozielski-Stuhrmann, U Kapp, L Terradot, GA Leonard, ...
Journal of Biological Chemistry 279 (53), 55840-55849, 2004
732004
Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability
HKS Leiros, AL Pey, M Innselset, E Moe, I Leiros, IH Steen, A Martinez
Journal of Biological Chemistry 282 (30), 21973-21986, 2007
662007
Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
A Sivertsen, J Isaksson, HKS Leiros, J Svenson, JS Svendsen, ...
BMC structural biology 14 (1), 4, 2014
652014
Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library
J Fu, HKS Leiros, D de Pascale, KA Johnson, HM Blencke, B Landfald
Applied microbiology and biotechnology 97 (9), 3965-3978, 2013
652013
Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?
HKS Leiros, J Timmins, RBG Ravelli, SM McSweeney
Acta Crystallographica Section D: Biological Crystallography 62 (2), 125-132, 2006
642006
Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5
E Wang, D Koutsioulis, HKS Leiros, OA Andersen, V Bouriotis, E Hough, ...
Journal of molecular biology 366 (4), 1318-1331, 2007
602007
Residue determinants and sequence analysis of cold-adapted trypsins
HKS Leiros, NP Willassen, AO Smalås
Extremophiles 3 (3), 205-219, 1999
591999
Electrostatics of mesophilic and psychrophilic trypsin isoenzymes: qualitative evaluation of electrostatic differences at the substrate binding site
AA Gorfe, BO Brandsdal, HKS Leiros, R Helland, AO Smalås
Proteins: Structure, Function, and Bioinformatics 40 (2), 207-217, 2000
452000
Crystal structure of the mobile metallo-β-lactamase AIM-1 from Pseudomonas aeruginosa: insights into antibiotic binding and the role of Gln157
HKS Leiros, PS Borra, BO Brandsdal, KSW Edvardsen, J Spencer, ...
Antimicrobial agents and chemotherapy 56 (8), 4341-4353, 2012
432012
Structure of a non-psychrophilic trypsin from a cold-adapted fish species
HK Schrøder, NP Willassen, AO Smalås
Acta Crystallographica Section D: Biological Crystallography 54 (5), 780-798, 1998
431998
Supercooled liquid-like solvent in trypsin crystals: Implications for crystal annealing and temperature-controlled X-ray radiation damage studies
M Weik, AMM Schreurs, HKS Leiros, G Zaccai, RBG Ravelli, P Gros
Journal of synchrotron radiation 12 (3), 310-317, 2005
392005
Discovery of novel inhibitor scaffolds against the metallo-β-lactamase VIM-2 by surface plasmon resonance (SPR) based fragment screening
T Christopeit, TJO Carlsen, R Helland, HKS Leiros
Journal of medicinal chemistry 58 (21), 8671-8682, 2015
362015
The first structure of a cold-active catalase from Vibrio salmonicida at 1.96 Å reveals structural aspects of cold adaptation
EK Riise, MS Lorentzen, R Helland, AO Smalås, HKS Leiros, ...
Acta Crystallographica Section D: Biological Crystallography 63 (2), 135-148, 2007
352007
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