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Thomas Kehrer
Thomas Kehrer
Senior Scientist, Regeneron Pharmaceuticals
Verified email at icahn.mssm.edu
Title
Cited by
Cited by
Year
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ...
Science 370 (6521), eabe9403, 2020
6152020
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
L Miorin, T Kehrer, MT Sanchez-Aparicio, K Zhang, P Cohen, RS Patel, ...
Proceedings of the National Academy of Sciences 117 (45), 28344-28354, 2020
4732020
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, ...
Science 371 (6532), 926-931, 2021
2972021
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
K Zhang, L Miorin, T Makio, I Dehghan, S Gao, Y Xie, H Zhong, M Esparza, ...
Science Advances 7 (6), eabe7386, 2021
1712021
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission
A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena, M Laporte, RL Pearl, ...
Cell host & microbe 30 (3), 373-387. e7, 2022
1452022
The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera
R Rathnasinghe, S Jangra, A Cupic, C Martínez-Romero, LCF Mulder, ...
MedRxiv, 2021
1132021
Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 human ACE2 transgenic mice
JA Silvas, DM Vasquez, JG Park, K Chiem, A Allué-Guardia, ...
Journal of Virology 95 (17), 10.1128/jvi. 00402-21, 2021
1052021
A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners
V Neira, B Brito, B Agüero, F Berrios, V Valdés, A Gutierrez, N Ariyama, ...
Emerging Microbes & Infections 10 (1), 376-383, 2021
862021
Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture
K Bafna, K White, B Harish, R Rosales, TA Ramelot, TB Acton, E Moreno, ...
Cell reports 35 (7), 2021
592021
HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle
D Jurczyszak, W Zhang, SN Terry, T Kehrer, MC Bermúdez González, ...
PLoS pathogens 16 (2), e1008305, 2020
482020
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
T Kehrer, A Cupic, C Ye, S Yildiz, M Bouhaddou, NA Crossland, ...
Cell Host & Microbe 31 (10), 1668-1684. e12, 2023
272023
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera
R Rathnasinghe, S Jangra, C Ye, A Cupic, G Singh, C Martínez-Romero, ...
Nature Communications 13 (1), 3921, 2022
242022
SARS-CoV-2 variants evolve convergent strategies to remodel the host response
M Bouhaddou, AK Reuschl, BJ Polacco, LG Thorne, MR Ummadi, C Ye, ...
Cell 186 (21), 4597-4614. e26, 2023
212023
Functional effects of cardiomyocyte injury in COVID-19
MM Siddiq, AT Chan, L Miorin, AS Yadaw, KG Beaumont, T Kehrer, ...
Journal of Virology 96 (2), e01063-21, 2022
182022
SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage
A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena, RL Pearl, M Laporte, ...
bioRxiv, 2021.08. 05.455290, 2021
182021
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters
L Miorin, CE Mire, S Ranjbar, AJ Hume, J Huang, NA Crossland, ...
bioRxiv, 2022.02. 08.479634, 2022
122022
Physiology of cardiomyocyte injury in COVID-19
MM Siddiq, AT Chan, L Miorin, AS Yadaw, KG Beaumont, T Kehrer, ...
Medrxiv, 2020
112020
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants
JA Duty, T Kraus, H Zhou, Y Zhang, N Shaabani, S Yildiz, N Du, A Singh, ...
Med 3 (10), 705-721. e11, 2022
102022
Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1
R Rathnasinghe, M Salvatore, H Zheng, S Jangra, T Kehrer, I Mena, ...
Scientific Reports 11 (1), 22164, 2021
92021
SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation
H Cai, Y Chen, Y Feng, M Asadi, L Kaufman, K Lee, T Kehrer, L Miorin, ...
Molecular Therapy 31 (3), 774-787, 2023
82023
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