Manuel R.Benito de las Heras
Manuel R.Benito de las Heras
Chair Professor, Complutense University of Madrid
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Reactive oxygen species (ROS) mediates the mitochondrial‐dependent apoptosis induced by transforming growth factor ß in fetal hepatocytes
The FASEB Journal 15 (3), 741-751, 2001
p38α mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli
A Porras, S Zuluaga, E Black, A Valladares, AM Alvarez, C Ambrosino, ...
Molecular biology of the cell 15 (2), 922-933, 2004
Apoptosis Induced by Transforming Growth Factor-in Fetal Hepatocyte Primary Cultures INVOLVEMENT OF REACTIVE OXYGEN INTERMEDIATES
A Sánchez, AM Álvarez, M Benito, I Fabregat
Journal of Biological Chemistry 271 (13), 7416-7422, 1996
The Epithelial Mesenchymal Transition Confers Resistance to the Apoptotic Effects of Transforming Growth Factor β in Fetal Rat Hepatocytes11 Ministerio de Sanidad y Consumo …
F Valdés, AM Álvarez, A Locascio, S Vega, B Herrera, M Fernández, ...
Molecular cancer research 1 (1), 68-78, 2002
β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes
J Klein, M Fasshauer, M Ito, BB Lowell, M Benito, CR Kahn
Journal of Biological Chemistry 274 (49), 34795-34802, 1999
Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance
C Guerra, P Navarro, AM Valverde, M Arribas, J Brüning, LP Kozak, ...
The Journal of clinical investigation 108 (8), 1205-1213, 2001
Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes
M Fasshauer, J Klein, KM Kriauciunas, K Ueki, M Benito, CR Kahn
Molecular and cellular biology 21 (1), 319-329, 2001
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes
M Fasshauer, J Klein, K Ueki, KM Kriauciunas, M Benito, MF White, ...
Journal of Biological Chemistry 275 (33), 25494-25501, 2000
Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes
M Benito, A Porras, AR Nebreda, E Santos
Science 253 (5019), 565-568, 1991
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes
AM Valverde, DJ Burks, I Fabregat, TL Fisher, J Carretero, MF White, ...
Diabetes 52 (9), 2239-2248, 2003
Insulin produces myogenesis in C2C12 myoblasts by induction of NF‐κB and downregulation of AP‐1 activities
R Conejo, AM Valverde, M Benito, M Lorenzo
Journal of cellular physiology 186 (1), 82-94, 2001
Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action
J Klein, M Fasshauer, HH Klein, M Benito, CR Kahn
Bioessays 24 (4), 382-388, 2002
IGF-I: a mitogen also involved in differentiation processes in mammalian cells
M Benito, AM Valverde, M Lorenzo
The international journal of biochemistry & cell biology 28 (5), 499-510, 1996
Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor β in fetal rat hepatocytes in primary culture
A Sanchez, AM Alvarez, M Benito, I Fabregat
Hepatology 26 (4), 935-943, 1997
Activation of caspases occurs downstream from radical oxygen species production, Bcl‐xL down‐regulation, and early cytochrome C release in apoptosis induced …
B Herrera, M Fernández, AM Alvarez, C Roncero, M Benito, J Gil, ...
Hepatology 34 (3), 548-556, 2001
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes
T Teruel, R Hernandez, M Benito, M Lorenzo
Journal of Biological Chemistry 278 (1), 263-269, 2003
Differential colorectal carcinogenesis: Molecular basis and clinical relevance
A Morán, P Ortega, C de Juan, T Fernández-Marcelo, C Frías, ...
World journal of gastrointestinal oncology 2 (3), 151, 2010
Correlations of telomere length, telomerase activity, and telomeric‐repeat binding factor 1 expression in colorectal carcinoma: Prognostic indications
C Garcia‐Aranda, C de Juan, A Diaz‐Lopez, A Sanchez‐Pernaute, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2006
The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance
AM Valverde, M Benito, M Lorenzo
Acta Physiologica Scandinavica 183 (1), 59-73, 2005
Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer
C Frías, C García-Aranda, C De Juan, A Morán, P Ortega, A Gómez, ...
Lung cancer 60 (3), 416-425, 2008
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