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Lu Huo
Lu Huo
Incyte Corporation
Verified email at incyte.com
Title
Cited by
Cited by
Year
Decarboxylation mechanisms in biological system
T Li, L Huo, C Pulley, A Liu
Bioorganic chemistry 43, 2-14, 2012
1252012
Evidence for a dual role of an active site histidine in α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase
L Huo, AJ Fielding, Y Chen, T Li, H Iwaki, JP Hosler, L Chen, Y Hasegawa, ...
Biochemistry 51 (29), 5811-5821, 2012
302012
Human α‐amino‐β‐carboxymuconate‐ε‐semialdehyde decarboxylase (ACMSD): A structural and mechanistic unveiling
L Huo, F Liu, H Iwaki, T Li, Y Hasegawa, A Liu
Proteins: Structure, Function, and Bioinformatics 83 (1), 178-187, 2015
282015
The power of two: arginine 51 and arginine 239* from a neighboring subunit are essential for catalysis in α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase
L Huo, I Davis, L Chen, A Liu
Journal of Biological Chemistry 288 (43), 30862-30871, 2013
242013
Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action
L Huo, I Davis, F Liu, B Andi, S Esaki, H Iwaki, Y Hasegawa, AM Orville, ...
Nature communications 6 (1), 5935, 2015
232015
Structure-function analysis of mammalian CYP2B enzymes using 7-substituted coumarin derivatives as probes: utility of crystal structures and molecular modeling in understanding …
MB Shah, J Liu, L Huo, Q Zhang, MD Dearing, PR Wilderman, GD Szklarz, ...
Molecular Pharmacology 89 (4), 435-445, 2016
172016
Amidohydrolase superfamily
A Liu, L Huo
eLS, 2014
142014
Rational Re-Engineering of the O-Dealkylation of 7-Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida
L Huo, J Liu, MD Dearing, GD Szklarz, JR Halpert, PR Wilderman
Biochemistry 56 (16), 2238-2246, 2017
82017
Heterolytic OO bond cleavage: Functional role of Glu113 during bis-Fe(IV) formation in MauG
AL Jiafeng Geng, Lu Huo
Journal of inorganic biochemistry 167, 60-67, 2017
52017
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors
A Sokolsky, S Winterton, K Kennedy, K Drake, K Stump, L Huo, Y Lo, ...
ACS Medicinal Chemistry Letters 13 (11), 1797-1804, 2022
42022
Kynurenine pathway regulation at its critical junctions with fluctuation of tryptophan
A Newton, L McCann, L Huo, A Liu
Metabolites 13 (4), 500, 2023
12023
Kynurenine Pathway Regulation at Its Critical Junctions with Fluctuation of Tryptophan. Metabolites 2023, 13, 500
A Newton, L McCann, L Huo, A Liu
2023
Extending the Kynurenine Pathway to an Aldehyde Disarming Enzyme: Mechanistic Study of Bacterial AMSDH and Identification of the Correct Human Enzyme
I Davis, L Huo, F Liu, B Andi, S Esaki, H Iwaki, Y Hasegawa, A Orville, ...
The FASEB Journal 29, 573.3, 2015
2015
Structural and Mechanistic Studies on à-Amino?-Carboxymuconate î-Semialdehyde Decarboxylase and à-Aminomuconate î-Semialdehyde Dehydrogenase
L Huo
2014
Structural and Mechanistic Studies on α-Amino β-Carboxymuconate ε-Semialdehyde Decarboxylase and α-Aminomuconate ε-Semialdehyde Dehydrogenase
L Huo
2014
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