| Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure− activity relationships, and X-ray crystallographic studies X Wen, H Sun, J Liu, K Cheng, P Zhang, L Zhang, J Hao, L Zhang, P Ni, ... Journal of Medicinal Chemistry 51 (12), 3540-3554, 2008 | 242 | 2008 |
| New inhibitors of glycogen phosphorylase as potential antidiabetic agents L Somsák, K Czifrák, M Tóth, E Bokor, ED Chrysina, KM Alexacou, ... Current medicinal chemistry 15 (28), 2933-2983, 2008 | 217 | 2008 |
| Glucose analog inhibitors of glycogen phosphorylase: The design of potential drugs for diabetes JL Martin, K Veluraja, K Ross, LN Johnson, GWJ Fleet, NG Ramsden, ... Biochemistry 30 (42), 10101-10116, 1991 | 175 | 1991 |
| The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 Å resolution S Iyer, DD Leonidas, GJ Swaminathan, D Maglione, M Battisti, M Tucci, ... Journal of Biological Chemistry 276 (15), 12153-12161, 2001 | 163 | 2001 |
| Design of Inhibitors of Glycogen Phosphorylase: A Study of. alpha.-and. beta.-C-Glucosides and 1-Thio-. beta.-D-glucose Compounds KA Watson, EP Mitchell, LN Johnson, CJF Bichard, MG Orchard, ... Biochemistry 33 (19), 5745-5758, 1994 | 161 | 1994 |
| Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion SJ Ackerman, L Liu, MA Kwatia, MP Savage, DD Leonidas, ... Journal of Biological Chemistry 277 (17), 14859-14868, 2002 | 153 | 2002 |
| Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents KE Tsitsanou, T Thireou, CE Drakou, K Koussis, MV Keramioti, ... Cellular and Molecular Life Sciences 69, 283-297, 2012 | 122 | 2012 |
| Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in … DD Leonidas, R Shapiro, SC Allen, GV Subbarao, K Veluraja, ... Journal of molecular biology 285 (3), 1209-1233, 1999 | 119 | 1999 |
| Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes JM Hayes, AL Kantsadi, DD Leonidas Phytochemistry Reviews 13, 471-498, 2014 | 109 | 2014 |
| Kinetic and crystallographic studies on 2‐(β‐D‐glucopyranosyl)‐5‐methyl‐1, 3, 4‐oxadiazole,‐benzothiazole, and‐benzimidazole, inhibitors of muscle glycogen phosphorylase b … ED Chrysina, MN Kosmopoulou, C Tiraidis, R Kardakaris, N Bischler, ... Protein science 14 (4), 873-888, 2005 | 108 | 2005 |
| Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors M Benltifa, JM Hayes, S Vidal, D Gueyrard, PG Goekjian, JP Praly, ... Bioorganic & medicinal chemistry 17 (20), 7368-7380, 2009 | 99 | 2009 |
| Crystal Structure of Eosinophil Cationic Protein at 2.4 Å Resolution, E Boix, DD Leonidas, Z Nikolovski, MV Nogués, CM Cuchillo, KR Acharya Biochemistry 38 (51), 16794-16801, 1999 | 98 | 1999 |
| Crystal Structures of Ribonuclease A Complexes with 5‘-Diphosphoadenosine 3‘-Phosphate and 5‘-Diphosphoadenosine 2‘-Phosphate at 1.7 Å Resolution, DD Leonidas, R Shapiro, LI Irons, N Russo, KR Acharya Biochemistry 36 (18), 5578-5588, 1997 | 98 | 1997 |
| Binding of N‐acetyl‐N ′‐β‐d‐glucopyranosyl urea and N‐benzoyl‐N ′‐β‐d‐glucopyranosyl urea to glycogen phosphorylase b Kinetic and … NG Oikonomakos, M Kosmopoulou, SE Zographos, DD Leonidas, ... European journal of biochemistry 269 (6), 1684-1696, 2002 | 97 | 2002 |
| Amide-1, 2, 3-triazole bioisosterism: the glycogen phosphorylase case ED Chrysina, É Bokor, KM Alexacou, MD Charavgi, GN Oikonomakos, ... Tetrahedron: Asymmetry 20 (6-8), 733-740, 2009 | 92 | 2009 |
| Nicotinic cholinergic system and COVID-19: in silico identification of an interaction between SARS-CoV-2 and nicotinic receptors with potential therapeutic targeting implications K Farsalinos, E Eliopoulos, DD Leonidas, GE Papadopoulos, S Tzartos, ... International journal of molecular sciences 21 (16), 5807, 2020 | 90 | 2020 |
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition NG Oikonomakos, C Tiraidis, DD Leonidas, SE Zographos, M Kristiansen, ... Journal of medicinal chemistry 49 (19), 5687-5701, 2006 | 86 | 2006 |
| The binding of β‐and γ‐cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies N Pinotsis, DD Leonidas, ED Chrysina, NG Oikonomakos, IM Mavridis Protein science 12 (9), 1914-1924, 2003 | 80 | 2003 |
| High‐resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure‐based design of ribonucleolytic … DD Leonidas, GB Chavali, NG Oikonomakos, ED Chrysina, ... Protein Science 12 (11), 2559-2574, 2003 | 73 | 2003 |
| 1-(3-Deoxy-3-fluoro-β-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies VG Tsirkone, E Tsoukala, C Lamprakis, S Manta, JM Hayes, VT Skamnaki, ... Bioorganic & medicinal chemistry 18 (10), 3413-3425, 2010 | 69 | 2010 |
Spyros E. ZographosInstitute of Chemical Biology, National Hellenic Research FoundationVerified email at eie.gr
