| Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme RS Basu, BA Warner, V Molodtsov, D Pupov, D Esyunina, ... Journal of Biological Chemistry 289 (35), 24549-24559, 2014 | 164 | 2014 |
| Structural basis of transcription-translation coupling RHE C Wang, V Molodtsov, E Firlar, JT Kaelber, G Blaha, M Su Science 369 (6509), 1359-1365, 2020 | 128 | 2020 |
| Allosteric effector ppGpp potentiates the inhibition of transcript initiation by DksA V Molodtsov, E Sineva, L Zhang, X Huang, M Cashel, SE Ades, ... Molecular cell 69 (5), 828-839. e5, 2018 | 109 | 2018 |
| Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis V Molodtsov, NT Scharf, MA Stefan, GA Garcia, KS Murakami Molecular microbiology 103 (6), 1034-1045, 2017 | 100 | 2017 |
| X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins V Molodtsov, IN Nawarathne, NT Scharf, PD Kirchhoff, HDH Showalter, ... Journal of medicinal chemistry 56 (11), 4758-4763, 2013 | 64 | 2013 |
| Mode of action of kanglemycin A, an ansamycin natural product that is active against rifampicin-resistant Mycobacterium tuberculosis H Mosaei, V Molodtsov, B Kepplinger, J Harbottle, CW Moon, RE Jeeves, ... Molecular cell 72 (2), 263-274. e5, 2018 | 57 | 2018 |
| X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved … V Molodtsov, PR Fleming, CJ Eyermann, AD Ferguson, MA Foulk, ... Journal of medicinal chemistry 58 (7), 3156-3171, 2015 | 50 | 2015 |
| Structural basis of Rho-dependent transcription termination V Molodtsov, C Wang, E Firlar, JT Kaelber, RH Ebright Nature 614 (7947), 367-374, 2023 | 42 | 2023 |
| RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription L Li, V Molodtsov, W Lin, RH Ebright, Y Zhang Proceedings of the National Academy of Sciences 117 (11), 5801-5809, 2020 | 32 | 2020 |
| Structure-function comparisons of (p) ppApp vs (p) ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro B Bruhn-Olszewska, V Molodtsov, M Sobala, M Dylewski, KS Murakami, ... Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1861 (8), 731-742, 2018 | 28 | 2018 |
| Transcript slippage and recoding M Anikin, V Molodtsov, D Temiakov, WT McAllister Recoding: expansion of decoding rules enriches gene expression, 409-432, 2010 | 26 | 2010 |
| The presence of an RNA: DNA hybrid that is prone to slippage promotes termination by T7 RNA polymerase V Molodtsov, M Anikin, WT McAllister Journal of molecular biology 426 (18), 3095-3107, 2014 | 25 | 2014 |
| Design, synthesis, and characterization of TNP-2198, a dual-targeted rifamycin-nitroimidazole conjugate with potent activity against microaerophilic and anaerobic bacterial … Z Ma, S He, Y Yuan, Z Zhuang, Y Liu, H Wang, J Chen, X Xu, C Ding, ... Journal of medicinal chemistry 65 (6), 4481-4495, 2022 | 20 | 2022 |
| X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway KS Murakami, Y Shin, CL Turnbough Jr, V Molodtsov Proceedings of the National Academy of Sciences 114 (31), 8211-8216, 2017 | 18 | 2017 |
| Novel chemical scaffolds for inhibition of rifamycin-resistant RNA polymerase discovered from high-throughput screening NT Scharf, V Molodtsov, A Kontos, KS Murakami, GA Garcia SLAS DISCOVERY: Advancing Life Sciences R&D 22 (3), 287-297, 2017 | 13 | 2017 |
| Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli MZ Qayyum, V Molodtsov, A Renda, KS Murakami Journal of Biological Chemistry 297 (6), 2021 | 12 | 2021 |
| Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance T Lan, US Ganapathy, S Sharma, YM Ahn, M Zimmerman, V Molodtsov, ... Angewandte Chemie (International ed. in English), e202211498, 2022 | 10 | 2022 |
| Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice J Haupenthal, Y Kautz, WAM Elgaher, L Pätzold, T Röhrig, ... ACS infectious diseases 6 (10), 2573-2581, 2020 | 7 | 2020 |
| Apoptosis and expression of vasopressin, insulin, and Bcl-2 in the neurosecretory system of aged mice VN Molodtsov, EV Senchenkov, ED Bazhanova Journal of Evolutionary Biochemistry and Physiology 42, 354-360, 2006 | 7 | 2006 |
| Structural and mechanistic basis of σ-dependent transcriptional pausing C Pukhrambam, V Molodtsov, M Kooshkbaghi, A Tareen, H Vu, ... Proceedings of the National Academy of Sciences 119 (23), e2201301119, 2022 | 5 | 2022 |
Katsuhiko S. MurakamiProfessor of Biochemistry and Molecular Biology, Pennsylvania State UniversityDirección de correo verificada de psu.edu
