| On-demand manufacturing of clinical-quality biopharmaceuticals LE Crowell, AE Lu, KR Love, A Stockdale, SM Timmick, D Wu, Y Wang, ... Nature biotechnology 36 (10), 988-995, 2018 | 101 | 2018 |
| Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice NC Dalvie, SA Rodriguez-Aponte, BL Hartwell, LH Tostanoski, ... Proceedings of the National Academy of Sciences 118 (38), e2106845118, 2021 | 68 | 2021 |
| Comparative analysis of the end-joining activity of several DNA ligases RJ Bauer, A Zhelkovsky, K Bilotti, LE Crowell, TC Evans Jr, ... PloS one 12 (12), e0190062, 2017 | 33 | 2017 |
| An impurity characterization based approach for the rapid development of integrated downstream purification processes SM Timmick, N Vecchiarello, C Goodwine, LE Crowell, KR Love, JC Love, ... Biotechnology and Bioengineering 115 (8), 2048-2060, 2018 | 28 | 2018 |
| Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffii NC Dalvie, AM Biedermann, SA Rodriguez‐Aponte, CA Naranjo, HD Rao, ... Biotechnology and Bioengineering 119 (2), 657-662, 2022 | 24 | 2022 |
| Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters NC Dalvie, SA Rodriguez-Aponte, BL Hartwell, LH Tostanoski, ... BioRxiv, 2021 | 19 | 2021 |
| Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus NC Dalvie, JR Brady, LE Crowell, MK Tracey, AM Biedermann, K Kaur, ... Microbial Cell Factories 20 (1), 94, 2021 | 14 | 2021 |
| A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and product‐related impurity removal N Vecchiarello, SM Timmick, C Goodwine, LE Crowell, KR Love, JC Love, ... Biotechnology and Bioengineering 116 (9), 2178-2190, 2019 | 14 | 2019 |
| Development of a platform process for the production and purification of single‐domain antibodies LE Crowell, C Goodwine, CS Holt, L Rocha, C Vega, SA Rodriguez, ... Biotechnology and Bioengineering 118 (9), 3348-3358, 2021 | 13 | 2021 |
| Rapid optimization of processes for the integrated purification of biopharmaceuticals LE Crowell, SA Rodriguez, KR Love, SM Cramer, JC Love Biotechnology and Bioengineering 118 (9), 3435-3446, 2021 | 6 | 2021 |
| The application of HPLC/MS analysis with a multi-enzyme digest strategy to characterize different interferon product variants produced from Pichia pastoris Y Wang, D Liu, LE Crowell, KR Love, S Wu, WS Hancock Amino acids 51, 1353-1363, 2019 | 5 | 2019 |
| Manufacturing strategies for sustainable supply of ultra-low cost vaccines for global health TP Chilima, L Crowell, JC Love, T Mukhopadhyay, SS Farid | 3 | 2018 |
| Systems and methods for manufacturing biologically-produced products JC Love, KR Love, L Crowell, A Stockdale, RD Braatz, AE Lu, S Cramer, ... US Patent App. 16/499,780, 2020 | 2 | 2020 |
| Accelerating process development for biologics on an automated, pharmacy-scale manufacturing system LE Crowell Massachusetts Institute of Technology, 2020 | 1 | 2020 |
| Large-Scale Purification and Characterization of Recombinant Receptor-Binding Domain (RBD) of SARS-CoV-2 Spike Protein Expressed in Yeast G Nagar, S Jain, M Rajurkar, R Lothe, H Rao, S Majumdar, M Gautam, ... Vaccines 11 (10), 1602, 2023 | | 2023 |
| Minimal purification method enables developability assessment of recombinant proteins SA Rodriguez‐Aponte, CA Naranjo, RS Johnston, NC Dalvie, LE Crowell, ... Biotechnology and Bioengineering, 2023 | | 2023 |
| Systems and methods for manufacturing biologically-produced products JC Love, KR Love, L Crowell, A Stockdale, RD Braatz, AE Lu, S Cramer, ... US Patent App. 17/690,876, 2023 | | 2023 |
| Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii (preprint) NC Dalvie, AM Biedermann, SA Rodriguez-Aponte, CA Naranjo, HD Rao, ... | | 2021 |
| Systems and methods for using behavior data of impurities and target proteins to design downstream processes JC Love, KR Love, S Cramer, S Timmick, N Vecchiarello, C Goodwine, ... US Patent App. 16/499,776, 2020 | | 2020 |
| Engineering quality and manufacturability of a trivalent protein subunit vaccine N Dalvie, JR Brady, MK Tracey, L Crowell, DL Kristensen, KR Love, ... 2019 AIChE Annual Meeting, 2019 | | 2019 |
J. Christopher LoveProfessor of Chemical Engineering, MITVerified email at mit.edu
