| Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ... Neuron 17 (5), 1005-1013, 1996 | 2088 | 1996 |
| Amyloid precursor protein trafficking, processing, and function G Thinakaran, EH Koo Journal of Biological Chemistry 283 (44), 29615-29619, 2008 | 1488 | 2008 |
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo G Thinakaran, DR Borchelt, MK Lee, HH Slunt, L Spitzer, G Kim, ... Neuron 17 (1), 181-190, 1996 | 1340 | 1996 |
| Trafficking and proteolytic processing of APP C Haass, C Kaether, G Thinakaran, S Sisodia Cold Spring Harbor perspectives in medicine 2 (5), a006270, 2012 | 1309 | 2012 |
| The role of presenilin cofactors in the γ-secretase complex N Takasugi, T Tomita, I Hayashi, M Tsuruoka, M Niimura, Y Takahashi, ... Nature 422 (6930), 438-441, 2003 | 1163 | 2003 |
| Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides H Xu, GK Gouras, JP Greenfield, B Vincent, J Naslund, L Mazzarelli, ... Nature medicine 4 (4), 447-451, 1998 | 695 | 1998 |
| Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ... Journal of Biological Chemistry 279 (43), 44945-44954, 2004 | 528 | 2004 |
| Protein topology of presenilin 1 A Doan, G Thinakaran, DR Borchelt, HH Slunt, T Ratovitsky, M Podlisny, ... Neuron 17 (5), 1023-1030, 1996 | 518 | 1996 |
| Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides JP Greenfield, J Tsai, GK Gouras, B Hai, G Thinakaran, F Checler, ... Proceedings of the National Academy of Sciences 96 (2), 742-747, 1999 | 514 | 1999 |
| Assessment of normal and mutant human presenilin function in Caenorhabditis elegans D Levitan, TG Doyle, D Brousseau, MK Lee, G Thinakaran, HH Slunt, ... Proceedings of the National Academy of Sciences 93 (25), 14940-14944, 1996 | 491 | 1996 |
| Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice CS Von Koch, H Zheng, H Chen, M Trumbauer, G Thinakaran, ... Neurobiology of aging 18 (6), 661-669, 1997 | 479 | 1997 |
| Effects of PS1 deficiency on membrane protein trafficking in neurons S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ... Neuron 21 (5), 1213-1221, 1998 | 476 | 1998 |
| Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). HH Slunt, G Thinakaran, C Von Koch, AC Lo, RE Tanzi, SS Sisodia Journal of Biological Chemistry 269 (4), 2637-2644, 1994 | 462 | 1994 |
| Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors G Thinakaran, CL Harris, T Ratovitski, F Davenport, HH Slunt, DL Price, ... Journal of Biological Chemistry 272 (45), 28415-28422, 1997 | 429 | 1997 |
| Metabolism of the “Swedish” amyloid precursor protein variant in neuro2a (N2a) cells: evidence that cleavage at the “β-secretase” site occurs in the Golgi apparatus (∗) G Thinakaran, DB Teplow, R Siman, B Greenberg, SS Sisodia Journal of Biological Chemistry 271 (16), 9390-9397, 1996 | 395 | 1996 |
| Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation H Xu, D Sweeney, R Wang, G Thinakaran, ACY Lo, SS Sisodia, ... Proceedings of the National Academy of Sciences 94 (8), 3748-3752, 1997 | 382 | 1997 |
| Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues MK Lee, HH Slunt, LJ Martin, G Thinakaran, G Kim, SE Gandy, M Seeger, ... Journal of Neuroscience 16 (23), 7513-7525, 1996 | 362 | 1996 |
| Comparative evaluation of synaptophysin-based methods for quantification of synapses ME Calhoun, M Jucker, LJ Martin, G Thinakaran, DL Price, PR Mouton Journal of neurocytology 25, 821-828, 1996 | 362 | 1996 |
| Membrane rafts in Alzheimer's disease beta-amyloid production KS Vetrivel, G Thinakaran Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2010 | 347 | 2010 |
| PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1 W Luo, H Wang, H Li, BS Kim, S Shah, HJ Lee, G Thinakaran, TW Kim, ... Journal of Biological Chemistry 278 (10), 7850-7854, 2003 | 346 | 2003 |
