Jean-Didier Maréchal
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An artificial heme enzyme for cyclopropanation reactions
L Villarino, KE Splan, E Reddem, L Alonso‐Cotchico, ...
Angewandte Chemie International Edition 57 (26), 7785-7789, 2018
Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury
TM Scarabelli, S Mariotto, S Abdel-Azeim, K Shoji, E Darra, A Stephanou, ...
FEBS letters 583 (3), 531-541, 2009
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition
CA Kemp, JU Flanagan, AJ Van Eldik, JD Maréchal, CR Wolf, ...
Journal of medicinal chemistry 47 (22), 5340-5346, 2004
Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency
WC Huang, ACG Westlake, JD Maréchal, MG Joyce, PCE Moody, ...
Journal of molecular biology 373 (3), 633-651, 2007
How do azoles inhibit cytochrome P450 enzymes? A density functional study
PR Balding, CS Porro, KJ McLean, MJ Sutcliffe, JD Maréchal, AW Munro, ...
The Journal of Physical Chemistry A 112 (50), 12911-12918, 2008
Incorporation of manganese complexes into xylanase: new artificial metalloenzymes for enantioselective epoxidation
M Allard, C Dupont, V Munoz Robles, N Doucet, A Lledós, JD Maréchal, ...
ChemBioChem 13 (2), 240-251, 2012
Why is quinidine an inhibitor of cytochrome P450 2D6?: the role of key active-site residues in quinidine binding
LA McLaughlin, MJI Paine, CA Kemp, JD Maréchal, JU Flanagan, ...
Journal of Biological Chemistry 280 (46), 38617-38624, 2005
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite
JU Flanagan, JD Maréchal, R Ward, CA Kemp, LA McLaughlin, ...
Biochemical Journal 380 (2), 353-360, 2004
Design of an enantioselective artificial metallo-hydratase enzyme containing an unnatural metal-binding amino acid
I Drienovská, L Alonso-Cotchico, P Vidossich, A Lledós, JD Maréchal, ...
Chemical science 8 (10), 7228-7235, 2017
Structural, kinetic, and docking studies of artificial imine reductases based on biotin–streptavidin technology: an induced lock-and-key hypothesis
VM Robles, M Dürrenberger, T Heinisch, A Lledos, T Schirmer, TR Ward, ...
Journal of the American Chemical Society 136 (44), 15676-15683, 2014
Insight into the apoptosis-inducing action of α-bisabolol towards malignant tumor cells: Involvement of lipid rafts and Bid
E Darra, S Abdel-Azeim, A Manara, K Shoji, JD Maréchal, S Mariotto, ...
Archives of Biochemistry and Biophysics 476 (2), 113-123, 2008
Three Dimensional Models of Cu2+-Aβ(1–16) Complexes from Computational Approaches
J Alí-Torres, JD Maréchal, L Rodríguez-Santiago, M Sodupe
Journal of the American Chemical Society 133 (38), 15008-15014, 2011
Normal mode analysis as a prerequisite for drug design: application to matrix metalloproteinases inhibitors
N Floquet, JD Marechal, MA Badet-Denisot, CH Robert, M Dauchez, ...
FEBS letters 580 (22), 5130-5136, 2006
Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules
Y Kapelyukh, MJI Paine, JD Maréchal, MJ Sutcliffe, CR Wolf, ...
Drug metabolism and disposition 36 (10), 2136-2144, 2008
Selective oxidation of aromatic sulfide catalyzed by an artificial metalloenzyme: new activity of hemozymes
R Ricoux, M Allard, R Dubuc, C Dupont, JD Maréchal, JP Mahy
Organic & Biomolecular Chemistry 7 (16), 3208-3211, 2009
In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer
JD Marechal, J Yu, S Brown, I Kapelioukh, EM Rankin, CR Wolf, ...
Drug metabolism and disposition 34 (4), 534-538, 2006
Amine conformational change and spin conversion induced by metal-assisted ligand oxidation: from the seven-coordinate iron (II)–TPAA complex to the two oxidized iron (II)–(py …
I Morgenstern-Badarau, F Lambert, JP Renault, M Cesario, JD Maréchal, ...
Inorganica Chimica Acta 297 (1-2), 338-350, 2000
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6‐drug interactions
JD Maréchal, CA Kemp, GCK Roberts, MJI Paine, CR Wolf, MJ Sutcliffe
British journal of pharmacology 153 (S1), S82-S89, 2008
Natural mutations of the anti-Müllerian hormone type II receptor found in persistent Müllerian duct syndrome affect ligand binding, signal transduction and cellular transport
C Belville, JD Maréchal, S Pennetier, P Carmillo, L Masgrau, ...
Human Molecular Genetics 18 (16), 3002-3013, 2009
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism
SA Malone, GE Papadakis, A Messina, NEH Mimouni, S Trova, ...
Elife 8, e47198, 2019
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