| Cyclodextrin-based gene delivery systems CO Mellet, JMG Fernández, JM Benito Chemical Society Reviews 40 (3), 1586-1608, 2011 | 418 | 2011 |
| Optimizing saccharide-directed molecular delivery to biological receptors: Design, synthesis, and biological evaluation of glycodendrimer− cyclodextrin conjugates JM Benito, M Gómez-García, C Ortiz Mellet, I Baussanne, J Defaye, ... Journal of the American Chemical Society 126 (33), 10355-10363, 2004 | 268 | 2004 |
| Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate–protein interactions Á Martínez, CO Mellet, JMG Fernández Chemical Society Reviews 42 (11), 4746-4773, 2013 | 245 | 2013 |
| Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect P Compain, C Decroocq, J Iehl, M Holler, D Hazelard, T Mena Barragan, ... Angewandte Chemie 122 (33), 5889-5892, 2010 | 228 | 2010 |
| Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters,-glycopolymers and-glycoassemblies JLJ Blanco, CO Mellet, JMG Fernández Chemical Society reviews 42 (11), 4518-4531, 2013 | 169 | 2013 |
| Probing secondary carbohydrate− protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: The heterocluster effect M Gómez-García, JM Benito, D Rodríguez-Lucena, JX Yu, K Chmurski, ... Journal of the American Chemical Society 127 (22), 7970-7971, 2005 | 154 | 2005 |
| Multivalent iminosugars to modulate affinity and selectivity for glycosidases J Diot, MI Garcia-Moreno, SG Gouin, CO Mellet, K Haupt, J Kovensky Organic & biomolecular chemistry 7 (2), 357-363, 2009 | 147 | 2009 |
| Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: Lessons from Gaucher, G M1-gangliosidosis and Fabry diseases EM Sánchez-Fernández, JMG Fernández, CO Mellet Chemical Communications 52 (32), 5497-5515, 2016 | 141 | 2016 |
| Multivalent cyclooligosaccharides: Versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands C Ortiz Mellet, J Defaye, JM García Fernández Chemistry–A European Journal 8 (9), 1982-1990, 2002 | 138 | 2002 |
| Pharmacological chaperone therapy for Gaucher disease: a patent review JM Benito, JM Garcia Fernandez, CO Mellet Expert opinion on therapeutic patents 21 (6), 885-903, 2011 | 136 | 2011 |
| Preorganized, macromolecular, gene‐delivery systems C Ortiz Mellet, JM Benito, JM Garcia Fernandez Chemistry–A European Journal 16 (23), 6728-6742, 2010 | 133 | 2010 |
| Polycationic amphiphilic cyclodextrins for gene delivery: synthesis and effect of structural modifications on plasmid DNA complex stability, cytotoxicity, and gene expression A Díaz‐Moscoso, L Le Gourriérec, M Gómez‐García, JM Benito, ... Chemistry–A European Journal 15 (46), 12871-12888, 2009 | 132 | 2009 |
| Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms … M de La Mata, D Cotán, M Oropesa-Ávila, J Garrido-Maraver, MD Cordero, ... Scientific reports 5 (1), 10903, 2015 | 124 | 2015 |
| Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides JM Benito, M Gómez-García, JL Jiménez Blanco, C Ortiz Mellet, ... The Journal of Organic Chemistry 66 (4), 1366-1372, 2001 | 120 | 2001 |
| Chemistry and developments of N-thiocarbonyl carbohydrate derivatives: sugar isothiocyanates, thioamides, thioureas, thiocarbamates, and their conjugates JMG Fernández, CO Mellet Advances in carbohydrate chemistry and biochemistry 55, 35-135, 2000 | 116 | 2000 |
| The multivalent effect in glycosidase inhibition: Probing the influence of architectural parameters with cyclodextrin‐based iminosugar click clusters C Decroocq, D Rodríguez‐Lucena, V Russo, T Mena Barragan, ... Chemistry–A European Journal 17 (49), 13825-13831, 2011 | 115 | 2011 |
| Isothiocyanates and cyclic thiocarbamates of α, α′-trehalose, sucrose, and cyclomaltooligosaccharides JMG Fernández, CO Mellet, JLJ Blanco, JF Mota, A Gadelle, ... Carbohydrate research 268 (1), 57-71, 1995 | 113 | 1995 |
| Insights in cellular uptake mechanisms of pDNA–polycationic amphiphilic cyclodextrin nanoparticles (CDplexes) A Díaz-Moscoso, D Vercauteren, J Rejman, JM Benito, CO Mellet, ... Journal of controlled release 143 (3), 318-325, 2010 | 112 | 2010 |
| Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery A Díaz-Moscoso, N Guilloteau, C Bienvenu, A Méndez-Ardoy, JLJ Blanco, ... Biomaterials 32 (29), 7263-7273, 2011 | 111 | 2011 |
| Fullerene‐sp2‐Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect R Rísquez‐Cuadro, JM Garcia Fernandez, JF Nierengarten, C Ortiz Mellet Chemistry–A European Journal 19 (49), 16791-16803, 2013 | 102 | 2013 |
Juan M BenitoTenured Scientist, Institute for Chemical Research, CSIC - U. SevillaVerified email at iiq.csic.es
