Ryan C. Gimple
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Targeting glioma stem cells through combined BMI1 and EZH2 inhibition
X Jin, LJY Kim, Q Wu, LC Wallace, BC Prager, T Sanvoranart, RC Gimple, ...
Nature medicine 23 (11), 1352-1361, 2017
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
SC Mack, KW Pajtler, L Chavez, K Okonechnikov, KC Bertrand, X Wang, ...
Nature 553 (7686), 101-105, 2018
Reciprocal signaling between glioblastoma stem cells and differentiated tumor cells promotes malignant progression
X Wang, BC Prager, Q Wu, LJY Kim, RC Gimple, Y Shi, K Yang, ...
Cell stem cell 22 (4), 514-528. e5, 2018
DNA methylation of the aryl hydrocarbon receptor repressor associations with cigarette smoking and subclinical atherosclerosis
LM Reynolds, M Wan, J Ding, JR Taylor, K Lohman, D Su, BD Bennett, ...
Circulation: Cardiovascular Genetics 8 (5), 707-716, 2015
Distinct epigenetic effects of tobacco smoking in whole blood and among leukocyte subtypes
D Su, X Wang, MR Campbell, DK Porter, GS Pittman, BD Bennett, M Wan, ...
PloS one 11 (12), e0166486, 2016
N6-methyladenine DNA modification in glioblastoma
Q Xie, TP Wu, RC Gimple, Z Li, BC Prager, Q Wu, Y Yu, P Wang, Y Wang, ...
Cell 175 (5), 1228-1243. e20, 2018
Targeting glioma stem cell-derived pericytes disrupts the blood-tumor barrier and improves chemotherapeutic efficacy
W Zhou, C Chen, Y Shi, Q Wu, RC Gimple, X Fang, Z Huang, K Zhai, ...
Cell Stem Cell 21 (5), 591-603. e4, 2017
MYC-regulated mevalonate metabolism maintains brain tumor–initiating cells
X Wang, Z Huang, Q Wu, BC Prager, SC Mack, K Yang, LJY Kim, ...
Cancer research 77 (18), 4947-4960, 2017
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
RC Gimple, S Bhargava, D Dixit, JN Rich
Genes & development 33 (11-12), 591-609, 2019
Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance
Y Shi, OA Guryanova, W Zhou, C Liu, Z Huang, X Fang, X Wang, C Chen, ...
Science translational medicine 10 (443), 2018
Functional enhancers shape extrachromosomal oncogene amplifications
AR Morton, N Dogan-Artun, ZJ Faber, G MacLeod, CF Bartels, MS Piazza, ...
Cell 179 (6), 1330-1341. e13, 2019
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells
X Wang, K Yang, Q Wu, LJY Kim, AR Morton, RC Gimple, BC Prager, ...
Science Translational Medicine 11 (504), eaau4972, 2019
Glioma stem cell–specific superenhancer promotes polyunsaturated fatty-acid synthesis to support EGFR signaling
RC Gimple, RL Kidwell, LJY Kim, T Sun, AD Gromovsky, Q Wu, M Wolf, ...
Cancer discovery 9 (9), 1248-1267, 2019
Targeting glioblastoma stem cells through disruption of the circadian clock
Z Dong, G Zhang, M Qu, RC Gimple, Q Wu, Z Qiu, BC Prager, X Wang, ...
Cancer discovery 9 (11), 1556-1573, 2019
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma
SC Mack, I Singh, X Wang, R Hirsch, Q Wu, R Villagomez, JA Bernatchez, ...
Journal of Experimental Medicine 216 (5), 1071-1090, 2019
Zika virus targets glioblastoma stem cells through a SOX2-integrin αvβ5 axis
Z Zhu, P Mesci, JA Bernatchez, RC Gimple, X Wang, ST Schafer, ...
Cell Stem Cell 26 (2), 187-204. e10, 2020
Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC
G Zhang, Z Dong, BC Prager, LJK Kim, Q Wu, RC Gimple, X Wang, S Bao, ...
JCI insight 4 (7), 2019
RAS: Striking at the Core of the Oncogenic Circuitry
RC Gimple, X Wang
Frontiers in oncology 9, 2019
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
M Tang, Q Xie, RC Gimple, Z Zhong, T Tam, J Tian, RL Kidwell, Q Wu, ...
Cell Research, 1-21, 2020
LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease
Q Chen, RC Gimple, G Li, J Chen, H Wu, R Li, J Xie, B Xu
Journal of biosciences 44 (1), 16, 2019
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