Serge Roche
Serge Roche
Directeur de recherche inserm
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PI 3‐kinase is a dual specificity enzyme: autoregulation by an intrinsic protein‐serine kinase activity.
R Dhand, I Hiles, G Panayotou, S Roche, MJ Fry, I Gout, NF Totty, ...
The EMBO journal 13 (3), 522-533, 1994
The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
S Roche, M Koegl, SA Courtneidge
Proceedings of the National Academy of Sciences 91 (19), 9185-9189, 1994
Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division
S Roche, S Fumagalli, SA Courtneidge
Science 269 (5230), 1567-1569, 1995
DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases
S Roche, M Koegl, MV Barone, MF Roussel, SA Courtneidge
Molecular and cellular biology 15 (2), 1102-1109, 1995
Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression
FX Mahon, S Hayette, V Lagarde, F Belloc, B Turcq, F Nicolini, ...
Cancer research 68 (23), 9809-9816, 2008
A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human …
C Bénistant, H Chapuis, S Roche
Oncogene 19 (44), 5083-5090, 2000
Cytoplasmic signalling by the c‐Abl tyrosine kinase in normal and cancer cells
A Sirvent, C Benistant, S Roche
Biology of the Cell 100 (11), 617-631, 2008
A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor
A Yart, M Laffargue, P Mayeux, S Chretien, C Peres, N Tonks, S Roche, ...
Journal of Biological Chemistry 276 (12), 8856-8864, 2001
A function for phosphatidylinositol 3-kinase β (p85α-p110β) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal transduction
S Roche, J Downward, P Raynal, SA Courtneidge
Molecular and cellular biology 18 (12), 7119-7129, 1998
Src and Ras are involved in separate pathways in epithelial cell scattering
B Boyer, S Roche, M Denoyelle, JP Thiery
The EMBO journal 16 (19), 5904-5913, 1997
c‐Abl is an effector of Src for growth factor‐induced c‐myc expression and DNA synthesis
O Furstoss, K Dorey, V Simon, D Barilà, G Superti‐Furga, S Roche
The EMBO journal, 2002
Calcium release at fertilization in starfish eggs is mediated by phospholipase Cγ
DJ Carroll, CS Ramarao, LM Mehlmann, S Roche, M Terasaki, LA Jaffe
The Journal of cell biology 138 (6), 1303-1311, 1997
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF‐induced DNA synthesis: evidence for the existence of Ras …
S Roche, J McGlade, M Jones, GD Gish, T Pawson, SA Courtneidge
The EMBO Journal 15 (18), 4940-4948, 1996
Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine …
A Pandey, MM Fernandez, H Steen, B Blagoev, MM Nielsen, S Roche, ...
Journal of Biological Chemistry 275 (49), 38633-38639, 2000
Syntenin mediates SRC function in exosomal cell-to-cell communication
NS Imjeti, K Menck, AL Egea-Jimenez, C Lecointre, F Lembo, ...
Proceedings of the National Academy of Sciences 114 (47), 12495-12500, 2017
Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells
C Leroy, C Fialin, A Sirvent, V Simon, S Urbach, J Poncet, B Robert, ...
Cancer research 69 (6), 2279-2286, 2009
Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells
R Gioia, C Leroy, C Drullion, V Lagarde, G Etienne, S Dulucq, E Lippert, ...
Blood, The Journal of the American Society of Hematology 118 (8), 2211-2221, 2011
An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid
M Laffargue, P Raynal, A Yart, C Peres, R Wetzker, S Roche, B Payrastre, ...
Journal of Biological Chemistry 274 (46), 32835-32841, 1999
A function for phosphoinositide 3-kinase β lipid products in coupling βγ to Ras activation in response to lysophosphatidic acid
A Yart, S Roche, R Wetzker, M Laffargue, N Tonks, P Mayeux, H Chap, ...
Journal of Biological Chemistry 277 (24), 21167-21178, 2002
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
E Lara-Pezzi, S Roche, OM Andrisani, F Sánchez-Madrid, ...
Oncogene 20 (26), 3323-3331, 2001
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Artículos 1–20