Anthony Segal
Anthony Segal
Professor of Medicine, UCL
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How neutrophils kill microbes
AW Segal
Annu. Rev. Immunol. 23, 197-223, 2005
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
EP Reeves, H Lu, HL Jacobs, CGM Messina, S Bolsover, G Gabella, ...
Nature 416 (6878), 291, 2002
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
EO Glocker, D Kotlarz, K Boztug, EM Gertz, AA Schäffer, F Noyan, M Perro, ...
New England Journal of Medicine 361 (21), 2033-2045, 2009
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1
A Abo, E Pick, A Hall, N Totty, CG Teahan, AW Segal
Nature 353 (6345), 668, 1991
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
F Altare, A Durandy, D Lammas, JF Emile, S Lamhamedi, F Le Deist, ...
Science 280 (5368), 1432-1435, 1998
The biochemical basis of the NADPH oxidase of phagocytes
AW Segal, A Abo
Trends in biochemical sciences 18 (2), 43-47, 1993
Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.
C O'moráin, AW Segal, AJ Levi
Br Med J (Clin Res Ed) 288 (6434), 1859-1862, 1984
The NADPH oxidase of professional phagocytes—prototype of the NOX electron transport chain systems
AR Cross, AW Segal
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1657 (1), 1-22, 2004
Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease
D Roos, M De Boer, F Kuribayashi, C Meischl, RS Weening, AW Segal, ...
Blood 87 (5), 1663-1681, 1996
Defective acute inflammation in Crohn's disease: a clinical investigation
DJB Marks, MWN Harbord, R MacAllister, FZ Rahman, J Young, ...
The Lancet 367 (9511), 668-678, 2006
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity
D Diekmann, A Abo, C Johnston, AW Segal, A Hall
Science 265 (5171), 531-533, 1994
Indium-111-labeled autologous leukocytes in man
ML Thakur, JP Lavender, RN Arnot, DJ Silvester, AW Segal
Journal of Nuclear medicine 18 (10), 1014-1021, 1977
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH
AW Segal, M Geisow, R Garcia, A Harper, R Miller
Nature 290 (5805), 406, 1981
Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.
KH In, K Asano, D Beier, J Grobholz, PW Finn, EK Silverman, ...
The Journal of clinical investigation 99 (5), 1130-1137, 1997
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
AM Smith, FZ Rahman, BH Hayee, SJ Graham, DJB Marks, GW Sewell, ...
Journal of Experimental Medicine 206 (9), 1883-1897, 2009
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G
J Tkalcevic, M Novelli, M Phylactides, JP Iredale, AW Segal, J Roes
Immunity 12 (2), 201-210, 2000
Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes
AW Segal, I West, F Wientjes, JHA Nugent, AJ Chavan, B Haley, ...
Biochemical Journal 284 (3), 781-788, 1992
Novel cytochrome b system in phagocytic vacuoles of human granulocytes
Nature 276 (5687), 515, 1978
Absence of both cytochrome b− 245 subunits from neutrophils in X-linked chronic granulomatous disease
AW Segal
Nature 326 (6108), 88-91, 1987
The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.
AW Segal
The Journal of clinical investigation 83 (6), 1785-1793, 1989
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Artículos 1–20