|How neutrophils kill microbes|
Annu. Rev. Immunol. 23, 197-223, 2005
|Killing activity of neutrophils is mediated through activation of proteases by K+ flux|
EP Reeves, H Lu, HL Jacobs, CGM Messina, S Bolsover, G Gabella, ...
Nature 416 (6878), 291, 2002
|Inflammatory bowel disease and mutations affecting the interleukin-10 receptor|
EO Glocker, D Kotlarz, K Boztug, EM Gertz, AA Schäffer, F Noyan, M Perro, ...
New England Journal of Medicine 361 (21), 2033-2045, 2009
|Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1|
A Abo, E Pick, A Hall, N Totty, CG Teahan, AW Segal
Nature 353 (6345), 668, 1991
|Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency|
F Altare, A Durandy, D Lammas, JF Emile, S Lamhamedi, F Le Deist, ...
Science 280 (5368), 1432-1435, 1998
|The biochemical basis of the NADPH oxidase of phagocytes|
AW Segal, A Abo
Trends in biochemical sciences 18 (2), 43-47, 1993
|Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.|
C O'moráin, AW Segal, AJ Levi
Br Med J (Clin Res Ed) 288 (6434), 1859-1862, 1984
|The NADPH oxidase of professional phagocytes—prototype of the NOX electron transport chain systems|
AR Cross, AW Segal
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1657 (1), 1-22, 2004
|Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease|
D Roos, M De Boer, F Kuribayashi, C Meischl, RS Weening, AW Segal, ...
Blood 87 (5), 1663-1681, 1996
|Defective acute inflammation in Crohn's disease: a clinical investigation|
DJB Marks, MWN Harbord, R MacAllister, FZ Rahman, J Young, ...
The Lancet 367 (9511), 668-678, 2006
|Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity|
D Diekmann, A Abo, C Johnston, AW Segal, A Hall
Science 265 (5171), 531-533, 1994
|Indium-111-labeled autologous leukocytes in man|
ML Thakur, JP Lavender, RN Arnot, DJ Silvester, AW Segal
Journal of Nuclear medicine 18 (10), 1014-1021, 1977
|The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH|
AW Segal, M Geisow, R Garcia, A Harper, R Miller
Nature 290 (5805), 406, 1981
|Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.|
KH In, K Asano, D Beier, J Grobholz, PW Finn, EK Silverman, ...
The Journal of clinical investigation 99 (5), 1130-1137, 1997
|Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease|
AM Smith, FZ Rahman, BH Hayee, SJ Graham, DJB Marks, GW Sewell, ...
Journal of Experimental Medicine 206 (9), 1883-1897, 2009
|Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G|
J Tkalcevic, M Novelli, M Phylactides, JP Iredale, AW Segal, J Roes
Immunity 12 (2), 201-210, 2000
|Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes|
AW Segal, I West, F Wientjes, JHA Nugent, AJ Chavan, B Haley, ...
Biochemical Journal 284 (3), 781-788, 1992
|Novel cytochrome b system in phagocytic vacuoles of human granulocytes|
AW Segal, OTG JONES
Nature 276 (5687), 515, 1978
|Absence of both cytochrome b− 245 subunits from neutrophils in X-linked chronic granulomatous disease|
Nature 326 (6108), 88-91, 1987
|The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.|
The Journal of clinical investigation 83 (6), 1785-1793, 1989