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| Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila JS Steffan, L Bodai, J Pallos, M Poelman, A McCampbell, BL Apostol, ... Nature 413 (6857), 739-743, 2001 | 1455 | 2001 |
| The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription JS Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, YZ Zhu, ... Proceedings of the National Academy of Sciences 97 (12), 6763-6768, 2000 | 1275 | 2000 |
| Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease E Hockly, VM Richon, B Woodman, DL Smith, X Zhou, E Rosa, ... Proceedings of the National Academy of Sciences 100 (4), 2041-2046, 2003 | 1046 | 2003 |
| SUMO modification of Huntingtin and Huntington's disease pathology JS Steffan, N Agrawal, J Pallos, E Rockabrand, LC Trotman, N Slepko, ... Science 304 (5667), 100-104, 2004 | 889 | 2004 |
| Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau KN Green, JS Steffan, H Martinez-Coria, X Sun, SS Schreiber, ... Journal of Neuroscience 28 (45), 11500-11510, 2008 | 459 | 2008 |
| IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome LM Thompson, CT Aiken, LS Kaltenbach, N Agrawal, K Illes, A Khoshnan, ... Journal of Cell Biology 187 (7), 1083-1099, 2009 | 437 | 2009 |
| Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice X Gu, ER Greiner, R Mishra, R Kodali, A Osmand, S Finkbeiner, ... Neuron 64 (6), 828-840, 2009 | 355 | 2009 |
| The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis E Rockabrand, N Slepko, A Pantalone, VN Nukala, A Kazantsev, ... Human molecular genetics 16 (1), 61-77, 2007 | 320 | 2007 |
| Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease J Pallos, L Bodai, T Lukacsovich, JM Purcell, JS Steffan, LM Thompson, ... Human molecular genetics 17 (23), 3767-3775, 2008 | 316 | 2008 |
| Potential function for the Huntingtin protein as a scaffold for selective autophagy J Ochaba, T Lukacsovich, G Csikos, S Zheng, J Margulis, L Salazar, ... Proceedings of the National Academy of Sciences 111 (47), 16889-16894, 2014 | 300 | 2014 |
| Histone deacetylase inhibitors reduce polyglutamine toxicity A McCampbell, AA Taye, L Whitty, E Penney, JS Steffan, KH Fischbeck Proceedings of the National Academy of Sciences 98 (26), 15179-15184, 2001 | 298 | 2001 |
| Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, ... Nature communications 11 (1), 5370, 2020 | 206 | 2020 |
| A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila A Kazantsev, HA Walker, N Slepko, JE Bear, E Preisinger, JS Steffan, ... Nature genetics 30 (4), 367-376, 2002 | 201 | 2002 |
| Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity CT Aiken, JS Steffan, CM Guerrero, H Khashwji, T Lukacsovich, ... Journal of Biological Chemistry 284 (43), 29427-29436, 2009 | 197 | 2009 |
| Treating the whole body in Huntington's disease JB Carroll, GP Bates, J Steffan, C Saft, SJ Tabrizi The Lancet Neurology 14 (11), 1135-1142, 2015 | 179 | 2015 |
| Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice A Di Pardo, V Maglione, M Alpaugh, M Horkey, RS Atwal, J Sassone, ... Proceedings of the National Academy of Sciences 109 (9), 3528-3533, 2012 | 178 | 2012 |
| The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor. JS Steffan, DA Keys, JA Dodd, M Nomura Genes & development 10 (20), 2551-2563, 1996 | 138 | 1996 |
| Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin–proteasomal and autophagy systems H Jia, RJ Kast, JS Steffan, EA Thomas Human molecular genetics 21 (24), 5280-5293, 2012 | 136 | 2012 |
| RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae. DA Keys, L Vu, JS Steffan, JA Dodd, RT Yamamoto, Y Nogi, M Nomura Genes & development 8 (19), 2349-2362, 1994 | 127 | 1994 |
