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Leslie M. Thompson
Leslie M. Thompson
Correu electrònic verificat a uci.edu
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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
ME MacDonald, CM Ambrose, MP Duyao, RH Myers, C Lin, L Srinidhi, ...
Cell 72 (6), 971-983, 1993
73391993
Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
R Shiang, LM Thompson, YZ Zhu, DM Church, TJ Fielder, M Bocian, ...
Cell 78 (2), 335-342, 1994
16001994
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
JS Steffan, L Bodai, J Pallos, M Poelman, A McCampbell, BL Apostol, ...
Nature 413 (6857), 739-743, 2001
14552001
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
JS Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, YZ Zhu, ...
Proceedings of the National Academy of Sciences 97 (12), 6763-6768, 2000
12752000
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
E Hockly, VM Richon, B Woodman, DL Smith, X Zhou, E Rosa, ...
Proceedings of the National Academy of Sciences 100 (4), 2041-2046, 2003
10462003
SUMO modification of Huntingtin and Huntington's disease pathology
JS Steffan, N Agrawal, J Pallos, E Rockabrand, LC Trotman, N Slepko, ...
Science 304 (5667), 100-104, 2004
8892004
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
AG Kazantsev, LM Thompson
Nature reviews Drug discovery 7 (10), 854-868, 2008
8632008
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
PL Tavormina, R Shiang, LM Thompson, YZ Zhu, DJ Wilkin, RS Lachman, ...
Nature genetics 9 (3), 321-328, 1995
6901995
Genome-wide analyses identify KIF5A as a novel ALS gene
A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ...
Neuron 97 (6), 1268-1283. e6, 2018
5792018
Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes
Hd iPsc Consortium
Cell stem cell 11 (2), 264-278, 2012
4892012
Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ...
Human molecular genetics 15 (18), 2743-2751, 2006
4652006
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
KN Green, JS Steffan, H Martinez-Coria, X Sun, SS Schreiber, ...
Journal of Neuroscience 28 (45), 11500-11510, 2008
4592008
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
LM Thompson, CT Aiken, LS Kaltenbach, N Agrawal, K Illes, A Khoshnan, ...
Journal of Cell Biology 187 (7), 1083-1099, 2009
4372009
The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ...
Cell systems 6 (1), 13-24, 2018
3922018
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
R Luthi-Carter, DM Taylor, J Pallos, E Lambert, A Amore, A Parker, ...
Proceedings of the National Academy of Sciences 107 (17), 7927-7932, 2010
3872010
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice
X Gu, ER Greiner, R Mishra, R Kodali, A Osmand, S Finkbeiner, ...
Neuron 64 (6), 828-840, 2009
3552009
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
X Zhang, DL Smith, AB Meriin, S Engemann, DE Russel, M Roark, ...
Proceedings of the national academy of sciences 102 (3), 892-897, 2005
3272005
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis
E Rockabrand, N Slepko, A Pantalone, VN Nukala, A Kazantsev, ...
Human molecular genetics 16 (1), 61-77, 2007
3202007
Mutant huntingtin disrupts the nuclear pore complex
JC Grima, JG Daigle, N Arbez, KC Cunningham, K Zhang, J Ochaba, ...
Neuron 94 (1), 93-107. e6, 2017
3182017
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease
J Pallos, L Bodai, T Lukacsovich, JM Purcell, JS Steffan, LM Thompson, ...
Human molecular genetics 17 (23), 3767-3775, 2008
3162008
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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