Tom Huxford

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Gourisankar GhoshUC San DiegoDirección de correo verificada de ucsd.edu
Scott B. HansenAssociate Professor, The Scripps Research InstituteDirección de correo verificada de scripps.edu
Yves BourneArchitecture et Fonction des Macromolécules Biologiques (AFMB, CNRS & AMU)Dirección de correo verificada de univ-amu.fr
Pascale MARCHOTCNRSDirección de correo verificada de univ-amu.fr
Elizabeth KomivesDistinguished Professor, Chemistry and Biochemistry UC San DiegoDirección de correo verificada de ucsd.edu
Sanford BernsteinSan Diego State UniversityDirección de correo verificada de sdsu.edu
Arthur V. HauensteinLycia TherapeuticsDirección de correo verificada de lyciatx.com
Christopher B PhelpsNurix TherapeuticsDirección de correo verificada de gsk.com
Alexander HoffmannUCLADirección de correo verificada de ucla.edu
Smarajit PolleyBose InstituteDirección de correo verificada de jcbose.ac.in
Vivien Ya-Fan WangUniversity of MacauDirección de correo verificada de um.edu.mo
Sankar Ghoshyale OR hhmi OR columbia OR einstein OR whiteheadDirección de correo verificada de columbia.edu
Youngchang KimScientist of X-ray Science Division, APS, Argonne National LaboratoryDirección de correo verificada de anl.gov
Inder VermaSalk InstituteDirección de correo verificada de salk.edu
Girish C. Melkani, MS, PhD, Associate...UAB, Heersink School of MedicineDirección de correo verificada de uab.edu
Sandeep RanaNCATS/ NIHDirección de correo verificada de nih.gov
Amar NatarajanProfessor, University of Nebraska Medical CenterDirección de correo verificada de unmc.edu
Banumathi SankaranLBNLDirección de correo verificada de lbl.gov
William Clarke GasperBoston UniversityDirección de correo verificada de bu.edu
Magnus KjaergaardDepartment of Molecular Biology and Genetics, Aarhus UniversityDirección de correo verificada de inano.au.dk

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Tom Huxford

Professor of Chemistry & Biochemistry, San Diego State University

Dirección de correo verificada de sdsu.edu - Página principal

NF-kappaB Metalloantibodies Myosin Signal Transduction Structural Biochemistry


Título Ordenar por citas Ordenar por año Ordenar por título	Citado por Citado por	Año
The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation T Huxford, DB Huang, S Malek, G Ghosh Cell 95 (6), 759-770, 1998	871	1998
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations SB Hansen, G Sulzenbacher, T Huxford, P Marchot, P Taylor, Y Bourne The EMBO journal 24 (20), 3635-3646, 2005	772	2005
IκBβ, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells S Malek, Y Chen, T Huxford, G Ghosh Journal of Biological Chemistry 276 (48), 45225-45235, 2001	294*	2001
NF-κB, IκB, and IKK: integral components of immune system signaling MC Mulero, T Huxford, G Ghosh Structural immunology, 207-226, 2019	231	2019
IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB S Malek, T Huxford, G Ghosh Journal of Biological Chemistry 273 (39), 25427-25435, 1998	227	1998
X-ray crystal structure of an IκBβ· NF-κB p65 homodimer complex S Malek, DB Huang, T Huxford, S Ghosh, G Ghosh Journal of Biological Chemistry 278 (25), 23094-23100, 2003	191	2003
A structural guide to proteins of the NF-κB signaling module T Huxford, G Ghosh Cold Spring Harbor perspectives in biology 1 (3), a000075, 2009	176	2009
Mechanism of IκBα binding to NF-κB dimers CB Phelps, LL Sengchanthalangsy, T Huxford, G Ghosh Journal of Biological Chemistry 275 (38), 29840-29846, 2000	148	2000
A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation S Polley, DB Huang, AV Hauenstein, AJ Fusco, X Zhong, D Vu, ... PLoS biology 11 (6), e1001581, 2013	128	2013
Biophysical characterization of the free IκBα ankyrin repeat domain in solution CH Croy, S Bergqvist, T Huxford, G Ghosh, EA Komives Protein Science 13 (7), 1767-1777, 2004	123	2004
The role of DNA in the mechanism of NFκB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits DB Huang, T Huxford, YQ Chen, G Ghosh Structure 5 (11), 1427-1436, 1997	116	1997
Genome reading by the NF-κB transcription factors MC Mulero, VYF Wang, T Huxford, G Ghosh Nucleic acids research 47 (19), 9967-9989, 2019	111	2019
Structure and mechanism in NF-κB/IκB signaling T Huxford, S Malek, G Ghosh Cold Spring Harbor symposia on quantitative biology 64, 533-540, 1999	108	1999
The nuclear IκB protein IκBζ specifically binds NF-κB p50 homodimers and forms a ternary complex on κB DNA DV Trinh, N Zhu, G Farhang, BJ Kim, T Huxford Journal of molecular biology 379 (1), 122-135, 2008	105	2008
Thermodynamics reveal that helix four in the NLS of NF-κB p65 anchors IκBα, forming a very stable complex S Bergqvist, CH Croy, M Kjaergaard, T Huxford, G Ghosh, EA Komives Journal of molecular biology 360 (2), 421-434, 2006	86	2006
The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen JM Wojciak, N Zhu, KT Schuerenberg, K Moreno, WS Shestowsky, ... Proceedings of the National Academy of Sciences 106 (42), 17717-17722, 2009	73	2009
Molecular mimicry of the NF-κB DNA target site by a selected RNA aptamer G Ghosh, DB Huang, T Huxford Current opinion in structural biology 14 (1), 21-27, 2004	52	2004
Understanding the logic of IκB: NF-κB regulation in structural terms T Huxford, A Hoffmann, G Ghosh NF-kB in Health and Disease, 1-24, 2011	45	2011
X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster CF Lee, AV Hauenstein, JK Fleming, WC Gasper, V Engelke, B Sankaran, ... Structure 19 (3), 397-408, 2011	44	2011
Solvent exposed non-contacting amino acids play a critical role in NF-κB/IκBα complex formation T Huxford, D Mishler, CB Phelps, DB Huang, LL Sengchanthalangsy, ... Journal of molecular biology 324 (4), 587-597, 2002	42	2002

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