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Girish C. Melkani
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Time-restricted eating to prevent and manage chronic metabolic diseases
A Chaix, ENC Manoogian, GC Melkani, S Panda
Annual review of nutrition 39, 291-315, 2019
3292019
Time-restricted feeding attenuates age-related cardiac decline in Drosophila
S Gill, HD Le, GC Melkani, S Panda
Science 347 (6227), 1265-1269, 2015
2622015
Time‐restricted feeding for prevention and treatment of cardiometabolic disorders
GC Melkani, S Panda
The Journal of physiology 595 (12), 3691-3700, 2017
1732017
Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
JE Villanueva, C Livelo, AS Trujillo, S Chandran, B Woodworth, ...
Nature communications 10 (1), 2700, 2019
1102019
Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart
GC Melkani, AS Trujillo, R Ramos, R Bodmer, SI Bernstein, K Ocorr
PLoS genetics 9 (12), e1004024, 2013
922013
Using Drosophila as an integrated model to study mild repetitive traumatic brain injury
A Barekat, A Gonzalez, RE Mauntz, RW Kotzebue, B Molina, ...
Scientific reports 6 (1), 25252, 2016
762016
αB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress
GC Melkani, A Cammarato, SI Bernstein
Journal of molecular biology 358 (3), 635-645, 2006
662006
The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model
GC Melkani, R Bodmer, K Ocorr, SI Bernstein
PloS one 6 (7), e22579, 2011
642011
The UNC-45 myosin chaperone: from worms to flies to vertebrates
CF Lee, GC Melkani, SI Bernstein
International review of cell and molecular biology 313, 103-144, 2014
622014
Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability
CF Lee, GC Melkani, Q Yu, JA Suggs, WA Kronert, Y Suzuki, L Hipolito, ...
Journal of cell science 124 (5), 699-705, 2011
442011
Increasing autophagy and blocking Nrf2 suppress laminopathy‐induced age‐dependent cardiac dysfunction and shortened lifespan
S Bhide, AS Trujillo, MT O'Connor, GH Young, DE Cryderman, ...
Aging cell 17 (3), e12747, 2018
392018
Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase
GC Melkani, CF Lee, A Cammarato, SI Bernstein
Biochemical and biophysical research communications 396 (2), 317-322, 2010
392010
Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy
WA Kronert, KM Bell, MC Viswanathan, GC Melkani, AS Trujillo, A Huang, ...
Elife 7, e38064, 2018
342018
Huntington’s disease-induced cardiac disorders affect multiple cellular pathways
GC Melkani
Reactive oxygen species (Apex, NC) 2 (5), 325, 2016
31*2016
The relay/converter interface influences hydrolysis of ATP by skeletal muscle myosin II
MJ Bloemink, GC Melkani, SI Bernstein, MA Geeves
Journal of Biological Chemistry 291 (4), 1763-1773, 2016
272016
The ATPase activity of GroEL is supported at high temperatures by divalent cations that stabilize its structure
GC Melkani, G Zardeneta, JA Mendoza
Biometals 16, 479-484, 2003
232003
Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head
MJ Bloemink, CM Dambacher, AF Knowles, GC Melkani, MA Geeves, ...
Journal of molecular biology 389 (4), 707-721, 2009
222009
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness
Y Wang, GC Melkani, JA Suggs, A Melkani, WA Kronert, A Cammarato, ...
Molecular biology of the cell 23 (11), 2057-2065, 2012
212012
TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan
GC Melkani, S Bhide, A Han, J Vyas, C Livelo, R Bodmer, SI Bernstein
FEBS letters 591 (21), 3447-3458, 2017
202017
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
MM Mihaylova, A Chaix, M Delibegovic, JJ Ramsey, J Bass, G Melkani, ...
Cell metabolism, 2023
192023
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