| Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity JR Graff, BW Konicek, TM Vincent, RL Lynch, D Monteith, SN Weir, ... The Journal of clinical investigation 117 (9), 2638-2648, 2007 | 465 | 2007 |
| Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. LF Stancato, YH Chow, KA Hutchison, GH Perdew, R Jove, WB Pratt Journal of Biological Chemistry 268 (29), 21711-21716, 1993 | 389 | 1993 |
| Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery: The role of p23 is to stabilize receptor· hsp90 heterocomplexes formed by … KD Dittmar, DR Demady, LF Stancato, P Krishna, WB Pratt Journal of Biological Chemistry 272 (34), 21213-21220, 1997 | 358 | 1997 |
| The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the … LF Stancato, AM Silverstein, JK Owens-Grillo, YH Chow, R Jove, WB Pratt Journal of Biological Chemistry 272 (7), 4013-4020, 1997 | 258 | 1997 |
| eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival JR Graff, BW Konicek, RL Lynch, CA Dumstorf, MS Dowless, AM McNulty, ... Cancer research 69 (9), 3866-3873, 2009 | 253 | 2009 |
| Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases BW Konicek, JR Stephens, AM McNulty, N Robichaud, RB Peery, ... Cancer research 71 (5), 1849-1857, 2011 | 247 | 2011 |
| RET solvent front mutations mediate acquired resistance to selective RET inhibition in RET-driven malignancies BJ Solomon, L Tan, JJ Lin, SQ Wong, S Hollizeck, K Ebata, BB Tuch, ... Journal of Thoracic Oncology 15 (4), 541-549, 2020 | 216 | 2020 |
| Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling WF Matter, T Estridge, C Zhang, R Belagaje, L Stancato, J Dixon, ... Biochemical and biophysical research communications 283 (5), 1061-1068, 2001 | 194 | 2001 |
| Antiproliferative action of interferon-α requires components of T-cell-receptor signalling EF Petricoin III, S Ito, BL Williams, S Audet, LF Stancato, A Gamero, ... Nature 390 (6660), 629-632, 1997 | 191 | 1997 |
| Preassociation of STAT1 with STAT2 and STAT3 in separate Signalling complexes prior to cytokine stimulation (∗) LF Stancato, M David, C Carter-Su, AC Larner, WB Pratt Journal of Biological Chemistry 271 (8), 4134-4137, 1996 | 190 | 1996 |
| Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity R Visconti, M Gadina, M Chiariello, EH Chen, LF Stancato, JS Gutkind, ... Blood, The Journal of the American Society of Hematology 96 (5), 1844-1852, 2000 | 186 | 2000 |
| Craf-1 protein kinase is essential for mouse development L Wojnowski, LF Stancato, AM Zimmer, H Hahn, TW Beck, AC Larner, ... Mechanisms of development 76 (1-2), 141-149, 1998 | 172 | 1998 |
| The 23-kDa Acidic Protein in Reticulocyte Lysate Is the Weakly Bound Component of the hsp Foldosome That Is Required for Assembly of the Glucocorticoid Receptor into a … KA Hutchison, LF Stancato, JK Owens-Grillo, JL Johnson, P Krishna, ... Journal of Biological Chemistry 270 (32), 18841-18847, 1995 | 160 | 1995 |
| Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis L Wojnowski, LF Stancato, AC Larner, UR Rapp, A Zimmer Mechanisms of development 91 (1-2), 97-104, 2000 | 153 | 2000 |
| Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway LF Stancato, M Sakatsume, M David, P Dent, F Dong, EF Petricoin, ... Molecular and cellular biology, 1997 | 138 | 1997 |
| Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity RM Campbell, BD Anderson, NA Brooks, HB Brooks, EM Chan, A De Dios, ... Molecular cancer therapeutics 13 (2), 364-374, 2014 | 125 | 2014 |
| Binding of immunophilins to the 90 kDa heat shock protein (hsp90) via a tetratricopeptide repeat domain is a conserved protein interaction in plants JK Owens-Grillo, LF Stancato, K Hoffmann, WB Pratt, P Krishna Biochemistry 35 (48), 15249-15255, 1996 | 111 | 1996 |
| A first-in-human phase I study of the oral p38 MAPK inhibitor, ralimetinib (LY2228820 dimesylate), in patients with advanced cancer A Patnaik, P Haluska, AW Tolcher, C Erlichman, KP Papadopoulos, ... Clinical Cancer Research 22 (5), 1095-1102, 2016 | 106 | 2016 |
| Animal and plant cell lysates share a conserved chaperone system that assembles the glucocorticoid receptor into a functional heterocomplex with hsp90 LF Stancato, KA Hutchison, P Krishna, WB Pratt Biochemistry 35 (2), 554-561, 1996 | 103 | 1996 |
| Cutting edge: involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role M Gadina, LM Stancato, CM Bacon, AC Larner, JJ O’Shea The Journal of Immunology 160 (10), 4657-4661, 1998 | 95 | 1998 |
Caitlin D LoweryEli Lilly and CompanyVerified email at lilly.com
