| Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors Y Du, H Yamaguchi, Y Wei, JL Hsu, HL Wang, YH Hsu, WC Lin, WH Yu, ... Nature medicine 22 (2), 194-201, 2016 | 227 | 2016 |
| H-NS forms a superhelical protein scaffold for DNA condensation ST Arold, PG Leonard, GN Parkinson, JE Ladbury Proceedings of the National Academy of Sciences 107 (36), 15728-15732, 2010 | 223 | 2010 |
| FAK dimerization controls its kinase‐dependent functions at focal adhesions K Brami‐Cherrier, N Gervasi, D Arsenieva, K Walkiewicz, MC Boutterin, ... The EMBO journal 33 (4), 356-370, 2014 | 142 | 2014 |
| Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation PG Leonard, D Golemi-Kotra, AM Stock Proceedings of the National Academy of Sciences 110 (21), 8525-8530, 2013 | 88 | 2013 |
| SF2312 is a natural phosphonate inhibitor of enolase PG Leonard, N Satani, D Maxwell, YH Lin, N Hammoudi, Z Peng, ... Nature chemical biology 12 (12), 1053-1058, 2016 | 87 | 2016 |
| Identification of potent and selective MTH1 inhibitors A Petrocchi, E Leo, NJ Reyna, MM Hamilton, X Shi, CA Parker, F Mseeh, ... Bioorganic & medicinal chemistry letters 26 (6), 1503-1507, 2016 | 83 | 2016 |
| Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding PG Leonard, IF Bezar, DJ Sidote, AM Stock Biochemistry 51 (50), 10035-10043, 2012 | 72 | 2012 |
| Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus R Guan, LC Ma, PG Leonard, BR Amer, H Sridharan, C Zhao, RM Krug, ... Proceedings of the National Academy of Sciences 108 (33), 13468-13473, 2011 | 61 | 2011 |
| Discovery of orally bioavailable chromone derivatives as potent and selective BRD4 inhibitors: scaffold hopping, optimization, and pharmacological evaluation Z Liu, H Chen, P Wang, Y Li, EA Wold, PG Leonard, S Joseph, AR Brasier, ... Journal of medicinal chemistry 63 (10), 5242-5256, 2020 | 60 | 2020 |
| Discovery of IPN60090, a clinical stage selective glutaminase-1 (GLS-1) inhibitor with excellent pharmacokinetic and physicochemical properties MJ Soth, K Le, ME Di Francesco, MM Hamilton, G Liu, JP Burke, ... Journal of medicinal chemistry 63 (21), 12957-12977, 2020 | 57 | 2020 |
| Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib Y Sun, BA Meyers, B Czako, P Leonard, F Mseeh, AL Harris, Q Wu, ... Cancer research 80 (21), 4840-4853, 2020 | 56 | 2020 |
| Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion Z Timsah, Z Ahmed, CC Lin, FA Melo, LJ Stagg, PG Leonard, P Jeyabal, ... Nature structural & molecular biology 21 (2), 180-188, 2014 | 55 | 2014 |
| Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies CKM Ip, PKS Ng, KJ Jeong, SH Shao, Z Ju, PG Leonard, X Hua, ... Nature communications 9 (1), 4583, 2018 | 50 | 2018 |
| 19F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus JM Aramini, K Hamilton, LC Ma, GVT Swapna, PG Leonard, JE Ladbury, ... Structure 22 (4), 515-525, 2014 | 50 | 2014 |
| An enolase inhibitor for the targeted treatment of ENO1-deleted cancers YH Lin, N Satani, N Hammoudi, VC Yan, Y Barekatain, S Khadka, ... Nature metabolism 2 (12), 1413-1426, 2020 | 47 | 2020 |
| Functional genomics reveals synthetic lethality between phosphogluconate dehydrogenase and oxidative phosphorylation Y Sun, M Bandi, T Lofton, M Smith, CA Bristow, A Carugo, N Rogers, ... Cell reports 26 (2), 469-482. e5, 2019 | 47 | 2019 |
| The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable C Benod, R Villagomez, CS Filgueira, PK Hwang, PG Leonard, ... PLoS One 9 (6), e99440, 2014 | 46 | 2014 |
| Investigation of the self‐association and hetero‐association interactions of H‐NS and StpA from Enterobacteria PG Leonard, S Ono, J Gor, SJ Perkins, JE Ladbury Molecular microbiology 73 (2), 165-179, 2009 | 45 | 2009 |
| A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin M Davlieva, Y Shi, PG Leonard, TA Johnson, MR Zianni, CA Arias, ... Nucleic acids research 43 (9), 4758-4773, 2015 | 44 | 2015 |
| Observed bromodomain flexibility reveals histone peptide-and small molecule ligand-compatible forms of ATAD2 G Poncet-Montange, Y Zhan, JP Bardenhagen, A Petrocchi, E Leo, X Shi, ... Biochemical Journal 466 (2), 337-346, 2015 | 42 | 2015 |
Florian MullerAssistant Professor UT MD Anderson Cancer CenterVerified email at mdanderson.org
