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Concepción González-Bello
Concepción González-Bello
Associate Professor of Organic Chemistry, Universidade de Santiago de Compostela
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Antibiotic adjuvants–A strategy to unlock bacterial resistance to antibiotics
C González-Bello
Bioorganic & medicinal chemistry letters 27 (18), 4221-4228, 2017
2552017
β-Lactamase inhibitors to restore the efficacy of antibiotics against superbugs
C Gonzalez-Bello, D Rodríguez, M Pernas, A Rodriguez, E Colchon
Journal of medicinal chemistry 63 (5), 1859-1881, 2019
1392019
Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases.
JM Harris, C Gonzalez-Bello, C Kleanthous, AR Hawkins, JR Coggins, ...
Biochemical journal 319 (Pt 2), 333, 1996
901996
Designing irreversible inhibitors—worth the effort?
C González‐Bello
ChemMedChem 11 (1), 22-30, 2016
842016
Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover
B Blanco, V Prado, E Lence, JM Otero, C Garcia-Doval, MJ van Raaij, ...
Journal of the American Chemical Society 135 (33), 12366-12376, 2013
762013
Using surface enhanced Raman scattering to analyze the interactions of protein receptors with bacterial quorum sensing modulators
C Costas, V López-Puente, G Bodelón, C Gonzalez-Bello, J Perez-Juste, ...
ACS nano 9 (5), 5567-5576, 2015
592015
Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium tuberculosis Type II Dehydroquinase
C Sánchez-Sixto, VFV Prazeres, L Castedo, H Lamb, AR Hawkins, ...
Journal of medicinal chemistry 48 (15), 4871-4881, 2005
522005
A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors
L Tizon, JM Otero, VFV Prazeres, AL Llamas-Saiz, GC Fox, MJ van Raaij, ...
Journal of medicinal chemistry 54 (17), 6063-6084, 2011
472011
Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas …
J Arca-Suárez, C Lasarte-Monterrubio, BK Rodiño-Janeiro, G Cabot, ...
Journal of Antimicrobial Chemotherapy 76 (1), 91-100, 2021
412021
Progress in type II dehydroquinase inhibitors: from concept to practice
C González‐Bello, L Castedo
Medicinal Research Reviews 27 (2), 177-208, 2007
392007
Activity of the β-lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii
JC Vázquez-Ucha, M Maneiro, M Martínez-Guitián, J Buynak, CR Bethel, ...
Antimicrobial Agents and Chemotherapy 61 (11), 10.1128/aac. 01172-17, 2017
382017
LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48
JA Vallejo, M Martinez-Guitian, JC Vázquez-Ucha, C González-Bello, ...
Journal of Antimicrobial Chemotherapy 71 (8), 2171-2180, 2016
382016
Synthesis of (2R)-2-bromodehydroquinic acid and (2R)-2-fluorodehydroquinic acid
MK Manthey, C González-Bello, C Abell
Journal of the Chemical Society, Perkin Transactions 1, 625-628, 1997
351997
Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency
A Peón, L Castedo, C González-Bello, B Blanco, H Lamb, A Sedes, ...
Organic Biomolecular Chemistry, 2012
332012
Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)‐2‐Benzyl‐3‐dehydroquinic Acids
A Peón, JM Otero, L Tizón, VFV Prazeres, AL Llamas‐Saiz, GC Fox, ...
ChemMedChem 5 (10), 1726-1733, 2010
332010
Selection of AmpC β-lactamase variants and metallo-β-lactamases leading to ceftolozane/tazobactam and ceftazidime/avibactam resistance during treatment of MDR/XDR Pseudomonas …
A Ruedas-López, I Alonso-García, C Lasarte-Monterrubio, ...
Antimicrobial Agents and Chemotherapy 66 (2), e02067-21, 2022
322022
Molecular and biochemical insights into the in vivo evolution of AmpC-mediated resistance to ceftolozane/tazobactam during treatment of an MDR Pseudomonas aeruginosa infection
J Arca-Suárez, JC Vázquez-Ucha, PA Fraile-Ribot, E Lence, G Cabot, ...
Journal of Antimicrobial Chemotherapy 75 (11), 3209-3217, 2020
322020
Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase
VFV Prazeres, C Sánchez‐Sixto, L Castedo, H Lamb, AR Hawkins, ...
ChemMedChem: Chemistry Enabling Drug Discovery 2 (2), 194-207, 2007
312007
Inhibition of shikimate kinase and type II dehydroquinase for antibiotic discovery: structure-based design and simulation studies
C Gonzalez-Bello
Current Topics in Medicinal Chemistry 16 (9), 960-977, 2016
302016
Synthesis of Lycorines by Intramolecular Aryne Cycloadditions
C González, D Pérez, E Guitián, L Castedo
J. Org. Chem. 60, 6318-632, 1995
291995
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