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Zachary Knight
Zachary Knight
UCSF and HHMI
Dirección de correo verificada de ucsf.edu - Página principal
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A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
ZA Knight, B Gonzalez, ME Feldman, ER Zunder, DD Goldenberg, ...
Cell 125 (4), 733-747, 2006
13782006
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
ME Feldman, B Apsel, A Uotila, R Loewith, ZA Knight, D Ruggero, ...
PLoS biology 7 (2), e1000038, 2009
13462009
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
S Sauer, L Bruno, A Hertweck, D Finlay, M Leleu, M Spivakov, ZA Knight, ...
Proceedings of the National Academy of Sciences 105 (22), 7797-7802, 2008
9652008
Targeting the cancer kinome through polypharmacology
ZA Knight, H Lin, KM Shokat
Nature Reviews Cancer 10 (2), 130-137, 2010
7902010
Features of selective kinase inhibitors
ZA Knight, KM Shokat
Chemistry & biology 12 (6), 621-637, 2005
7902005
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
QW Fan, ZA Knight, DD Goldenberg, W Yu, KE Mostov, D Stokoe, ...
Cancer cell 9 (5), 341-349, 2006
7542006
Sensory detection of food rapidly modulates arcuate feeding circuits
Y Chen, YC Lin, TW Kuo, ZA Knight
Cell 160 (5), 829-841, 2015
5532015
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
B Apsel, JA Blair, B Gonzalez, TM Nazif, ME Feldman, B Aizenstein, ...
Nature chemical biology 4 (11), 691, 2008
5512008
Regulation of body temperature by the nervous system
CL Tan, ZA Knight
Neuron 98 (1), 31-48, 2018
4612018
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
OK Mirzoeva, D Das, LM Heiser, S Bhattacharya, D Siwak, R Gendelman, ...
Cancer research 69 (2), 565-572, 2009
4342009
Hyperleptinemia is required for the development of leptin resistance
ZA Knight, KS Hannan, ML Greenberg, JM Friedman
PloS one 5 (6), e11376, 2010
3392010
Warm-sensitive neurons that control body temperature
CL Tan, EK Cooke, DE Leib, YC Lin, GE Daly, CA Zimmerman, ZA Knight
Cell 167 (1), 47-59. e15, 2016
3262016
Phosphospecific proteolysis for mapping sites of protein phosphorylation
ZA Knight, B Schilling, RH Row, DM Kenski, BW Gibson, KM Shokat
Nature biotechnology 21 (9), 1047-1054, 2003
3212003
Molecular profiling of activated neurons by phosphorylated ribosome capture
ZA Knight, K Tan, K Birsoy, S Schmidt, JL Garrison, RW Wysocki, ...
Cell 151 (5), 1126-1137, 2012
3202012
Chemical genetics: where genetics and pharmacology meet
ZA Knight, KM Shokat
Cell 128 (3), 425-430, 2007
2922007
Genetic identification of vagal sensory neurons that control feeding
L Bai, S Mesgarzadeh, KS Ramesh, EL Huey, Y Liu, LA Gray, TJ Aitken, ...
Cell 179 (5), 1129-1143. e23, 2019
2892019
Thirst neurons anticipate the homeostatic consequences of eating and drinking
CA Zimmerman, YC Lin, DE Leib, L Guo, EL Huey, GE Daly, Y Chen, ...
Nature 537 (7622), 680-684, 2016
2682016
A dual phosphoinositide-3-kinase α/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
QW Fan, CK Cheng, TP Nicolaides, CS Hackett, ZA Knight, KM Shokat, ...
Cancer research 67 (17), 7960-7965, 2007
2552007
Neural circuits underlying thirst and fluid homeostasis
CA Zimmerman, DE Leib, ZA Knight
Nature Reviews Neuroscience 18 (8), 459-469, 2017
2522017
Identification of preoptic sleep neurons using retrograde labelling and gene profiling
S Chung, F Weber, P Zhong, CL Tan, TN Nguyen, KT Beier, N Hörmann, ...
Nature 545 (7655), 477-481, 2017
2502017
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Artículos 1–20