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karen duff
karen duff
Verified email at columbia.edu
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Year
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13123*2021
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
D Morgan, DM Diamond, PE Gottschall, KE Ugen, C Dickey, J Hardy, ...
Nature 408 (6815), 982-985, 2000
21322000
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
20431996
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
L Holcomb, MN Gordon, E McGowan, X Yu, S Benkovic, P Jantzen, ...
Nature medicine 4 (1), 97-100, 1998
17161998
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
J Lewis, E McGowan, J Rockwood, H Melrose, P Nacharaju, ...
Nature genetics 25 (4), 402-405, 2000
16102000
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo, MA Pappolla, B Malester, J LaFrancois, T Bryant-Thomas, ...
Neurobiology of disease 7 (4), 321-331, 2000
13202000
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu, AM Cuervo, A Kumar, CM Peterhoff, SD Schmidt, JH Lee, ...
The Journal of cell biology 171 (1), 87-98, 2005
11582005
Trans-synaptic spread of tau pathology in vivo
L Liu, V Drouet, JW Wu, MP Witter, SA Small, C Clelland, K Duff
PloS one 7 (2), e31302, 2012
11322012
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
W Noble, E Planel, C Zehr, V Olm, J Meyerson, F Suleman, K Gaynor, ...
Proceedings of the national academy of sciences 102 (19), 6990-6995, 2005
9132005
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
CA Saura, SY Choi, V Beglopoulos, S Malkani, D Zhang, BSS Rao, ...
Neuron 42 (1), 23-36, 2004
8852004
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
C Andorfer, Y Kress, M Espinoza, R De Silva, KL Tucker, YA Barde, K Duff, ...
Journal of neurochemistry 86 (3), 582-590, 2003
8592003
Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
SA Small, K Duff
Neuron 60 (4), 534-542, 2008
7322008
A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease
LM Refolo, MA Pappolla, J LaFrancois, B Malester, SD Schmidt, ...
Neurobiology of disease 8 (5), 890-899, 2001
7022001
Neuronal activity enhances tau propagation and tau pathology in vivo
JW Wu, SA Hussaini, IM Bastille, GA Rodriguez, A Mrejeru, K Rilett, ...
Nature neuroscience 19 (8), 1085-1092, 2016
6842016
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
J Tsai, J Grutzendler, K Duff, WB Gan
Nature neuroscience 7 (11), 1181-1183, 2004
6682004
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease
UA Khan, L Liu, FA Provenzano, DE Berman, CP Profaci, R Sloan, ...
Nature neuroscience 17 (2), 304-311, 2014
6132014
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
C Andorfer, CM Acker, Y Kress, PR Hof, K Duff, P Davies
Journal of Neuroscience 25 (22), 5446-5454, 2005
6112005
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
W Noble, V Olm, K Takata, E Casey, O Mary, J Meyerson, K Gaynor, ...
Neuron 38 (4), 555-565, 2003
5812003
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
RB Chan, TG Oliveira, EP Cortes, LS Honig, KE Duff, SA Small, MR Wenk, ...
Journal of Biological Chemistry 287 (4), 2678-2688, 2012
5802012
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
JW Wu, M Herman, L Liu, S Simoes, CM Acker, H Figueroa, JI Steinberg, ...
Journal of Biological Chemistry 288 (3), 1856-1870, 2013
5662013
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