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Christoph Rader
Christoph Rader
Chief Technology Officer, Aethon Therapeutics, Inc.
Dirección de correo verificada de aethontx.com - Página principal
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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
L Zhang, CB Jackson, H Mou, A Ojha, H Peng, BD Quinlan, ...
Nature communications 11 (1), 6013, 2020
9852020
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
M Hudecek, MT Lupo-Stanghellini, PL Kosasih, D Sommermeyer, ...
Clinical cancer research 19 (12), 3153-3164, 2013
6312013
Humanization of murine antibody
CF Barbas III, C Rader
US Patent 7,087,409, 2006
5532006
The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
M Hudecek, D Sommermeyer, PL Kosasih, A Silva-Benedict, L Liu, ...
Cancer immunology research 3 (2), 125-135, 2015
5452015
Phage display of combinatorial antibody libraries
C Rader, CF Barbas III
Current opinion in biotechnology 8 (4), 503-508, 1997
3411997
The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor
M Hudecek, TM Schmitt, S Baskar, MT Lupo-Stanghellini, T Nishida, ...
Blood, The Journal of the American Society of Hematology 116 (22), 4532-4541, 2010
3252010
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia
S Baskar, KY Kwong, T Hofer, JM Levy, MG Kennedy, E Lee, LM Staudt, ...
Clinical Cancer Research 14 (2), 396-404, 2008
3092008
The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein
K Venkatesh, O Chivatakarn, H Lee, PS Joshi, DB Kantor, BA Newman, ...
Journal of Neuroscience 25 (4), 808-822, 2005
3022005
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
D Bagnara, MS Kaufman, C Calissano, S Marsilio, PEM Patten, R Simone, ...
Blood, The Journal of the American Society of Hematology 117 (20), 5463-5472, 2011
2962011
Methods for the generation of chicken monoclonal antibody fragments by phage display
J Andris-Widhopf, C Rader, P Steinberger, R Fuller, CF Barbas Iii
Journal of immunological methods 242 (1-2), 159-181, 2000
2962000
A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries
C Rader, DA Cheresh, CF Barbas III
Proceedings of the National Academy of Sciences 95 (15), 8910-8915, 1998
2831998
Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals
T Derfuss, K Parikh, S Velhin, M Braun, E Mathey, M Krumbholz, ...
Proceedings of the National Academy of Sciences 106 (20), 8302-8307, 2009
2762009
Logic-gated ROR1 chimeric antigen receptor expression rescues T cell-mediated toxicity to normal tissues and enables selective tumor targeting
S Srivastava, AI Salter, D Liggitt, S Yechan-Gunja, M Sarvothama, ...
Cancer cell 35 (3), 489-503. e8, 2019
2482019
Immunogenic chemotherapy enhances recruitment of CAR-T cells to lung tumors and improves antitumor efficacy when combined with checkpoint blockade
S Srivastava, SN Furlan, CA Jaeger-Ruckstuhl, M Sarvothama, C Berger, ...
Cancer cell 39 (2), 193-208. e10, 2021
1892021
Safety of targeting ROR1 in primates with chimeric antigen receptor–modified T cells
C Berger, D Sommermeyer, M Hudecek, M Berger, A Balakrishnan, ...
Cancer immunology research 3 (2), 206-216, 2015
1832015
Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected …
M Popkov, RG Mage, CB Alexander, S Thundivalappil, CF Barbas III, ...
Journal of molecular biology 325 (2), 325-335, 2003
1702003
The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies
C Rader, G Ritter, S Nathan, M Elia, I Gout, AA Jungbluth, LS Cohen, ...
Journal of Biological Chemistry 275 (18), 13668-13676, 2000
1692000
Multiple event activation of a generic prodrug trigger by antibody catalysis
D Shabat, C Rader, B List, RA Lerner, CF Barbas III
Proceedings of the National Academy of Sciences 96 (12), 6925-6930, 1999
1601999
Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element
MA DiMattia, NR Watts, SJ Stahl, C Rader, PT Wingfield, DI Stuart, ...
Proceedings of the National Academy of Sciences 107 (13), 5810-5814, 2010
1512010
Clinical development of a poly (2-oxazoline)(POZ) polymer therapeutic for the treatment of Parkinson’s disease–Proof of concept of POZ as a versatile polymer platform for drug …
RW Moreadith, TX Viegas, MD Bentley, JM Harris, Z Fang, K Yoon, ...
European Polymer Journal 88, 524-552, 2017
1502017
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