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Maria A. Telpoukhovskaia
Maria A. Telpoukhovskaia
Dirección de correo verificada de jax.org
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The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases
C Rodríguez-Rodríguez, M Telpoukhovskaia, C Orvig
Coordination Chemistry Reviews 256 (19-20), 2308-2332, 2012
1882012
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis
ME Ward, R Chen, HY Huang, C Ludwig, M Telpoukhovskaia, A Taubes, ...
Science translational medicine 9 (385), eaah5642, 2017
1712017
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain
L Zhan, G Krabbe, F Du, I Jones, MC Reichert, M Telpoukhovskaia, ...
PLoS biology 17 (2), e3000134, 2019
1342019
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
C Wang, MA Telpoukhovskaia, BA Bahr, X Chen, L Gan
Current Opinion in Neurobiology 48, 52-58, 2018
1312018
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
TE Tracy, J Madero-Pérez, DL Swaney, TS Chang, M Moritz, C Konrad, ...
Cell 185 (4), 712-728. e14, 2022
1212022
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
FA Sayed, M Telpoukhovskaia, L Kodama, Y Li, Y Zhou, D Le, A Hauduc, ...
Proceedings of the National Academy of Sciences 115 (40), 10172-10177, 2018
1212018
Werner coordination chemistry and neurodegeneration
MA Telpoukhovskaia, C Orvig
Chemical Society Reviews 42 (4), 1836-1846, 2013
1202013
N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4 (1H)-pyridinones as agents for Alzheimer's therapy
LE Scott, M Telpoukhovskaia, C Rodríguez-Rodríguez, M Merkel, ...
Chemical Science 2 (4), 642-648, 2011
862011
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix [4] arene scaffold
LK Tsou, GE Dutschman, EA Gullen, M Telpoukhovskaia, YC Cheng, ...
Bioorganic & medicinal chemistry letters 20 (7), 2137-2139, 2010
752010
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
FA Sayed, L Kodama, L Fan, GK Carling, JC Udeochu, D Le, Q Li, L Zhou, ...
Science Translational Medicine 13 (622), eabe3947, 2021
552021
Exploring the multifunctionality of thioflavin-and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease
MA Telpoukhovskaia, BO Patrick, C Rodríguez-Rodríguez, C Orvig
Molecular BioSystems 9 (4), 792-805, 2013
362013
Translational approaches to understanding resilience to Alzheimer’s disease
SM Neuner, M Telpoukhovskaia, V Menon, KMS O’Connell, TJ Hohman, ...
Trends in neurosciences 45 (5), 369-383, 2022
322022
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors
MA Telpoukhovskaia, BO Patrick, C Rodríguez-Rodríguez, C Orvig
Bioorganic & Medicinal Chemistry Letters 26 (6), 1624-1628, 2016
302016
3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability
MA Telpoukhovskaia, JF Cawthray, C Rodríguez-Rodríguez, LE Scott, ...
Bioorganic & Medicinal Chemistry Letters 25 (17), 3654-3657, 2015
242015
Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models
C Rodríguez-Rodríguez, MA Telpoukhovskaia, J Alí-Torres, ...
Metallomics 7 (1), 83-92, 2015
242015
3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents
MA Telpoukhovskaia, C Rodríguez-Rodríguez, JF Cawthray, LE Scott, ...
Metallomics 6 (2), 249-262, 2014
242014
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
MA Telpoukhovskaia, K Liu, FA Sayed, JI Etchegaray, M Xie, L Zhan, Y Li, ...
Scientific reports 10 (1), 13688, 2020
172020
Synthesis, characterization, and cytotoxicity studies of Cu (II), Zn (II), and Fe (III) complexes of< i> N-</i> derivatized 3-hydroxy-4-pyridiones
MA Telpoukhovskaia, C Rodríguez-Rodríguez, LE Scott, BDG Page, ...
Journal of Inorganic Biochemistry 132, 59-66, 2014
162014
Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neurons
MA Telpoukhovskaia, N Hadad, B Gurdon, Y Dai, AR Ouellette, ...
bioRxiv, 2022.04. 12.487877, 2022
52022
AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans
FA Sayed, L Kodama, JC Udeochu, L Fan, GK Carling, D Le, Q Li, L Zhou, ...
bioRxiv, 2020.07. 24.218719, 2020
52020
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