Lluís Raich
Lluís Raich
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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
M Hoffmann, H Hofmann-Winkler, JC Smith, N Krüger, P Arora, ...
EBioMedicine 65, 2021
Alpha 1 antitrypsin is an inhibitor of the SARS-CoV-2–priming protease TMPRSS2
NP Azouz, AM Klingler, V Callahan, IV Akhrymuk, K Elez, L Raich, ...
Pathogens And Immunity 6 (1), 55, 2021
Molecular-scale ligand effects in small gold–thiolate nanoclusters
DM Chevrier, L Raich, C Rovira, A Das, Z Luo, Q Yao, A Chatt, J Xie, R Jin, ...
Journal of the American Chemical Society 140 (45), 15430-15436, 2018
Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
T Hempel, L Raich, S Olsson, NP Azouz, AM Klingler, M Hoffmann, ...
Chemical Science 12 (3), 983-992, 2021
1, 6-Cyclophellitol cyclosulfates: a new class of irreversible glycosidase inhibitor
M Artola, L Wu, MJ Ferraz, CL Kuo, L Raich, IZ Breen, WA Offen, ...
ACS central science 3 (7), 784-793, 2017
A trapped covalent intermediate of a glycoside hydrolase on the pathway to transglycosylation. insights from experiments and quantum mechanics/molecular mechanics simulations
L Raich, V Borodkin, W Fang, J Castro-Lopez, DMF van Aalten, ...
Journal of the American Chemical Society 138 (10), 3325-3332, 2016
The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases
J Iglesias-Fernández, L Raich, A Ardèvol, C Rovira
Chemical science 6 (2), 1167-1177, 2015
A β-mannanase with a lysozyme-like fold and a novel molecular catalytic mechanism
Y Jin, M Petricevic, A John, L Raich, H Jenkins, L Portela De Souza, ...
ACS central science 2 (12), 896-903, 2016
Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes
SP Schröder, C De Boer, NGS McGregor, RJ Rowland, O Moroz, ...
ACS central science 5 (6), 1067-1078, 2019
An epoxide intermediate in glycosidase catalysis
LF Sobala, G Speciale, S Zhu, L Raich, N Sannikova, AJ Thompson, ...
ACS central science 6 (5), 760-770, 2020
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
MK Bilyard, HJ Bailey, L Raich, MA Gafitescu, T Machida, ...
Nature 563 (7730), 235-240, 2018
Precise probing of residue roles by post-translational β, γ-C, N aza-Michael mutagenesis in enzyme active sites
J Dadová, KJ Wu, PG Isenegger, JC Errey, GJL Bernardes, JM Chalker, ...
ACS central science 3 (11), 1168-1173, 2017
Enzymatic cleavage of glycosidic bonds: strategies on how to set up and control a QM/MM metadynamics simulation
L Raich, A Nin-Hill, A Ardèvol, C Rovira
Methods in enzymology 577, 159-183, 2016
Structural and mechanistic insights into the catalytic-domain-mediated short-range glycosylation preferences of GalNAc-T4
M de Las Rivas, EJ Paul Daniel, H Coelho, E Lira-Navarrete, L Raich, ...
ACS Central Science 4 (9), 1274-1290, 2018
Carba-cyclophellitols are neutral retaining-glucosidase inhibitors
TJM Beenakker, DPA Wander, WA Offen, M Artola, L Raich, MJ Ferraz, ...
Journal of the American Chemical Society 139 (19), 6534-6537, 2017
Modeling catalytic reaction mechanisms in glycoside hydrolases
J Coines, L Raich, C Rovira
Current Opinion in Chemical Biology 53, 183-191, 2019
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine. 2021; 65: 103255
M Hoffmann, H Hofmann-Winkler, JC Smith, N Krüger, P Arora, ...
DOI 10 (2020.08), 05.237651, 2021
A Single Point Mutation Converts GH84 O-GlcNAc Hydrolases into Phosphorylases: Experimental and Theoretical Evidence
D Teze, J Coines, L Raich, V Kalichuk, C Solleux, C Tellier, C André-Miral, ...
Journal of the American Chemical Society 142 (5), 2120-2124, 2020
Discovery of a hidden transient state in all bromodomain families
L Raich, K Meier, J Günther, CD Christ, F Noé, S Olsson
Proceedings of the National Academy of Sciences 118 (4), e2017427118, 2021
Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase
M Petricevic, LF Sobala, PZ Fernandes, L Raich, AJ Thompson, ...
Journal of the American Chemical Society 139 (3), 1089-1097, 2017
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