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Frederic Vaillancourt
Frederic Vaillancourt
SVP, Head of Early Research, Remix Therapeutics
Dirección de correo verificada de remixtx.com
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Nature's inventory of halogenation catalysts: oxidative strategies predominate
FH Vaillancourt, E Yeh, DA Vosburg, S Garneau-Tsodikova, CT Walsh
Chemical reviews 106 (8), 3364-3378, 2006
6062006
The ins and outs of ring-cleaving dioxygenases
FH Vaillancourt, JT Bolin, LD Eltis
Critical Reviews in Biochemistry and Molecular Biology 41 (4), 241-267, 2006
4842006
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis
LC Blasiak, FH Vaillancourt, CT Walsh, CL Drennan
Nature 440 (7082), 368-371, 2006
4222006
SyrB2 in syringomycin E biosynthesis is a nonheme FeII α-ketoglutarate-and O2-dependent halogenase
FH Vaillancourt, J Yin, CT Walsh
Proceedings of the National Academy of Sciences 102 (29), 10111-10116, 2005
3762005
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
FH Vaillancourt, E Yeh, DA Vosburg, SE O'Connor, CT Walsh
Nature 436 (7054), 1191-1194, 2005
3532005
Substrate-triggered formation and remarkable stability of the C− H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2
ML Matthews, CM Krest, EW Barr, FH Vaillancourt, CT Walsh, MT Green, ...
Biochemistry 48 (20), 4331-4343, 2009
2572009
Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis
DP Galonić, FH Vaillancourt, CT Walsh
Journal of the American Chemical Society 128 (12), 3900-3901, 2006
2092006
Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains
CJ Balibar, FH Vaillancourt, CT Walsh
Chemistry & biology 12 (11), 1189-1200, 2005
1902005
Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication
FH Vaillancourt, L Pilote, M Cartier, J Lippens, M Liuzzi, RC Bethell, ...
Virology 387 (1), 5-10, 2009
1692009
Definitive evidence for monoanionic binding of 2, 3-dihydroxybiphenyl to 2, 3-dihydroxybiphenyl 1, 2-dioxygenase from UV resonance Raman spectroscopy, UV/Vis absorption …
FH Vaillancourt, CJ Barbosa, TG Spiro, JT Bolin, MW Blades, RFB Turner, ...
Journal of the American Chemical Society 124 (11), 2485-2496, 2002
1502002
The mechanism-based inactivation of 2, 3-dihydroxybiphenyl 1, 2-dioxygenase by catecholic substrates
FH Vaillancourt, G Labbé, NM Drouin, PD Fortin, LD Eltis
Journal of Biological Chemistry 277 (3), 2019-2027, 2002
1472002
Identification and analysis of a bottleneck in PCB biodegradation
S Dai, FH Vaillancourt, H Maaroufi, NM Drouin, DB Neau, V Snieckus, ...
nature structural biology 9 (12), 934-939, 2002
1322002
Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1, 2-dioxygenase by t-butanol
FH Vaillancourt, S Han, PD Fortin, JT Bolin, LD Eltis
Journal of Biological Chemistry 273 (52), 34887-34895, 1998
1031998
Enzymatic generation of the antimetabolite γ, γ-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete
M Ueki, DP Galonić, FH Vaillancourt, S Garneau-Tsodikova, E Yeh, ...
Chemistry & biology 13 (11), 1183-1191, 2006
992006
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
X Puyang, C Furman, GZ Zheng, ZJ Wu, D Banka, K Aithal, S Agoulnik, ...
Cancer discovery 8 (9), 1176-1193, 2018
942018
Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo
C Spickler, J Lippens, MK Laberge, S Desmeules, É Bellavance, ...
Antimicrobial agents and chemotherapy 57 (7), 3358-3368, 2013
882013
Evaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug target
FH Vaillancourt, M Brault, L Pilote, N Uyttersprot, ET Gaillard, JH Stoltz, ...
Journal of virology 86 (21), 11595-11607, 2012
692012
Dichlorination and bromination of a threonyl-S-carrier protein by the non-heme Fe (II) halogenase SyrB2.
FH Vaillancourt, DA Vosburg, CT Walsh
Chembiochem: a European Journal of Chemical Biology 7 (5), 748-752, 2006
672006
Spectroscopic and Electronic Structure Studies of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase:  O2 Reactivity of the Non-Heme Ferrous Site in Extradiol Dioxygenases
MI Davis, EC Wasinger, A Decker, MYM Pau, FH Vaillancourt, JT Bolin, ...
Journal of the American Chemical Society 125 (37), 11214-11227, 2003
672003
Characterization of extradiol dioxygenases from a polychlorinated biphenyl-degrading strain that possess higher specificities for chlorinated metabolites
FH Vaillancourt, MA Haro, NM Drouin, Z Karim, H Maaroufi, LD Eltis
Journal of bacteriology 185 (4), 1253-1260, 2003
542003
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