| Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches JGM Bessems, NPE Vermeulen Critical reviews in toxicology 31 (1), 55-138, 2001 | 990 | 2001 |
| Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 S Adler, D Basketter, S Creton, O Pelkonen, J Van Benthem, V Zuang, ... Archives of toxicology 85, 367-485, 2011 | 630 | 2011 |
| Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention NPE Vermeulen, JGM Bessems, R Van de Straat Drug metabolism reviews 24 (3), 367-407, 1992 | 481 | 1992 |
| Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches S Coecke, O Pelkonen, SB Leite, U Bernauer, JGM Bessems, FY Bois, ... Toxicology in vitro 27 (5), 1570-1577, 2013 | 158 | 2013 |
| PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA–EURL ECVAM ADME workshop JG Bessems, G Loizou, K Krishnan, HJ Clewell III, C Bernasconi, F Bois, ... Regulatory Toxicology and Pharmacology 68 (1), 119-139, 2014 | 147 | 2014 |
| Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future H Louro, M Heinälä, J Bessems, J Buekers, T Vermeire, M Woutersen, ... International journal of hygiene and environmental health 222 (5), 727-737, 2019 | 138 | 2019 |
| Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps G Loizou, M Spendiff, HA Barton, J Bessems, FY Bois, MB d’Yvoire, ... Regulatory Toxicology and Pharmacology 50 (3), 400-411, 2008 | 123 | 2008 |
| Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making A Paini, JA Leonard, E Joossens, JGM Bessems, A Desalegn, JL Dorne, ... Computational Toxicology 9, 61-72, 2019 | 120 | 2019 |
| Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing … E de Jong, M Barenys, SAB Hermsen, A Verhoef, BC Ossendorp, ... Toxicology and applied pharmacology 253 (2), 103-111, 2011 | 98 | 2011 |
| Subacute (28-day) toxicity of furfural in Fischer 344 rats: a comparison of the oral and inhalation route JHE Arts, H Muijser, MJ Appel, CF Kuper, JGM Bessems, RA Woutersen Food and chemical toxicology 42 (9), 1389-1399, 2004 | 80 | 2004 |
| Chemical prioritisation strategy in the European human biomonitoring initiative (HBM4EU)–development and results E Ougier, C Ganzleben, P Lecoq, J Bessems, M David, G Schoeters, ... International Journal of Hygiene and Environmental Health 236, 113778, 2021 | 68 | 2021 |
| Quantitative Extrapolation of In Vitro Whole Embryo Culture Embryotoxicity Data to Developmental Toxicity In Vivo Using the Benchmark Dose Approach AH Piersma, G Janer, G Wolterink, JGM Bessems, BC Hakkert, W Slob Toxicological sciences 101 (1), 91-100, 2008 | 58 | 2008 |
| The relation between the oxidative biotransformation of hexachlorobenzene and its porphyrinogenic activity B van Ommen, W Hendriks, JGM Bessems, G Geesink, F Müller, ... Toxicology and applied pharmacology 100 (3), 517-528, 1989 | 54 | 1989 |
| Towards a systematic use of effect biomarkers in population and occupational biomonitoring MZ Jeddi, NB Hopf, S Viegas, AB Price, A Paini, C van Thriel, E Benfenati, ... Environment International 146, 106257, 2021 | 53 | 2021 |
| Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study AS Kienhuis, JGM Bessems, JLA Pennings, M Driessen, M Luijten, ... Toxicology and Applied Pharmacology 250 (2), 96-107, 2011 | 52 | 2011 |
| EURL ECVAM status report on the development, validation and regulatory acceptance of alternative methods and approaches (2019) D Asturiol Bofill Publications Office of the European Union, 2020 | 50 | 2020 |
| Improving the applicability of (Q) SARs for percutaneous penetration in regulatory risk assessment T Bouwman, MTD Cronin, JGM Bessems, JJM Van de Sandt Human & experimental toxicology 27 (4), 269-276, 2008 | 46 | 2008 |
| Assessment of mixtures-review of regulatory requirements and guidance A Kienzler, E Berggren, J Bessems, S Bopp, S van der Linden, A Worth JRC Science for Policy Report, EUR 26675EN. Luxembourg: Publications Office …, 2014 | 44 | 2014 |
| Oral-to-inhalation route extrapolation in occupational health risk assessment: a critical assessment MAJ Rennen, T Bouwman, A Wilschut, JGM Bessems, C De Heer Regulatory Toxicology and Pharmacology 39 (1), 5-11, 2004 | 44 | 2004 |
| Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes L Qiu-Ju, JGM Bessems, JNM Commandeur, B Adams, NPE Vermeulen Biochemical pharmacology 48 (8), 1631-1640, 1994 | 43 | 1994 |
