|Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA|
MR Redinbo, L Stewart, P Kuhn, JJ Champoux, WGJ Hol
Science 279 (5356), 1504-1513, 1998
|The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity|
RE Watkins, GB Wisely, LB Moore, JL Collins, MH Lambert, SP Williams, ...
Science 292 (5525), 2329-2333, 2001
|A model for the mechanism of human topoisomerase I|
L Stewart, MR Redinbo, X Qiu, WGJ Hol, JJ Champoux
Science 279 (5356), 1534-1541, 1998
|Alleviating cancer drug toxicity by inhibiting a bacterial enzyme|
BD Wallace, H Wang, KT Lane, JE Scott, J Orans, JS Koo, M Venkatesh, ...
Science 330 (6005), 831-835, 2010
|Crystal structure of an ancient protein: evolution by conformational epistasis|
EA Ortlund, JT Bridgham, MR Redinbo, JW Thornton
Science 317 (5844), 1544-1548, 2007
|Regulation of cyp3a gene transcription by the pregnane x receptor|
B Goodwin, MR Redinbo, SA Kliewer
Annual review of pharmacology and toxicology 42 (1), 1-23, 2002
|Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4|
M Venkatesh, S Mukherjee, H Wang, H Li, K Sun, AP Benechet, Z Qiu, ...
Immunity 41 (2), 296-310, 2014
|2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,|
RE Watkins, JM Maglich, LB Moore, GB Wisely, SM Noble, ...
Biochemistry 42 (6), 1430-1438, 2003
|Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor|
RE Watkins, PR Davis-Searles, MH Lambert, MR Redinbo
Journal of molecular biology 331 (4), 815-828, 2003
|Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme|
S Bencharit, CL Morton, Y Xue, PM Potter, MR Redinbo
Nature Structural & Molecular Biology 10 (5), 349-356, 2003
|Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole|
H Huang, H Wang, M Sinz, M Zoeckler, J Staudinger, MR Redinbo, ...
Oncogene 26 (2), 258-268, 2007
|Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin|
JE Chrencik, J Orans, LB Moore, Y Xue, L Peng, JL Collins, GB Wisely, ...
Molecular Endocrinology 19 (5), 1125-1134, 2005
|Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics|
MR Redinbo, PM Potter
Drug discovery today 10 (5), 313-325, 2005
|The role of the microbiome in cancer development and therapy|
AP Bhatt, MR Redinbo, SJ Bultman
CA: a cancer journal for clinicians 67 (4), 326-344, 2017
|Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily|
G Schaaf, EA Ortlund, KR Tyeryar, CJ Mousley, KE Ile, TA Garrett, J Ren, ...
Molecular cell 29 (2), 191-206, 2008
|Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP|
EA Ortlund, Y Lee, IH Solomon, JM Hager, R Safi, Y Choi, Z Guan, ...
Nature structural & molecular biology 12 (4), 357-363, 2005
|Structural insights into CPT-11 activation by mammalian carboxylesterases|
S Bencharit, CL Morton, EL Howard-Williams, MK Danks, PM Potter, ...
Nature structural biology 9 (5), 337-342, 2002
|Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7|
MJ Miley, AK Zielinska, JE Keenan, SM Bratton, A Radominska-Pandya, ...
Journal of molecular biology 369 (2), 498-511, 2007
|Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA|
MR Redinbo, JJ Champoux, WGJ Hol
Biochemistry 39 (23), 6832-6840, 2000
|Plastocyanin: structural and functional analysis|
MR Redinbo, TO Yeates, S Merchant
Journal of bioenergetics and biomembranes 26 (1), 49-66, 1994