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Matthew Redinbo
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Year
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
MR Redinbo, L Stewart, P Kuhn, JJ Champoux, WGJ Hol
Science 279 (5356), 1504-1513, 1998
11441998
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
BD Wallace, H Wang, KT Lane, JE Scott, J Orans, JS Koo, M Venkatesh, ...
Science 330 (6005), 831-835, 2010
9922010
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
RE Watkins, GB Wisely, LB Moore, JL Collins, MH Lambert, SP Williams, ...
Science 292 (5525), 2329-2333, 2001
9512001
A model for the mechanism of human topoisomerase I
L Stewart, MR Redinbo, X Qiu, WGJ Hol, JJ Champoux
Science 279 (5356), 1534-1541, 1998
8981998
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
M Venkatesh, S Mukherjee, H Wang, H Li, K Sun, AP Benechet, Z Qiu, ...
Immunity 41 (2), 296-310, 2014
8262014
The role of the microbiome in cancer development and therapy
AP Bhatt, MR Redinbo, SJ Bultman
CA: a cancer journal for clinicians 67 (4), 326-344, 2017
5702017
Crystal structure of an ancient protein: evolution by conformational epistasis
EA Ortlund, JT Bridgham, MR Redinbo, JW Thornton
Science 317 (5844), 1544-1548, 2007
4982007
Regulation of CYP3A Gene Transcription by the Pregnane X Receptor
B Goodwin, MR Redinbo, SA Kliewer
Annual review of pharmacology and toxicology 42 (1), 1-23, 2002
4392002
2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,
RE Watkins, JM Maglich, LB Moore, GB Wisely, SM Noble, ...
Biochemistry 42 (6), 1430-1438, 2003
4252003
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
RE Watkins, PR Davis-Searles, MH Lambert, MR Redinbo
Journal of molecular biology 331 (4), 815-828, 2003
2632003
Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
G Schaaf, EA Ortlund, KR Tyeryar, CJ Mousley, KE Ile, TA Garrett, J Ren, ...
Molecular cell 29 (2), 191-206, 2008
2612008
Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics
MR Redinbo, PM Potter
Drug discovery today 10 (5), 313-325, 2005
2552005
Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
S Bencharit, CL Morton, Y Xue, PM Potter, MR Redinbo
Nature Structural & Molecular Biology 10 (5), 349-356, 2003
2502003
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
2492015
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
H Huang, H Wang, M Sinz, M Zoeckler, J Staudinger, MR Redinbo, ...
Oncogene 26 (2), 258-268, 2007
2462007
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin
JE Chrencik, J Orans, LB Moore, Y Xue, L Peng, JL Collins, GB Wisely, ...
Molecular endocrinology 19 (5), 1125-1134, 2005
2442005
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7
MJ Miley, AK Zielinska, JE Keenan, SM Bratton, A Radominska-Pandya, ...
Journal of molecular biology 369 (2), 498-511, 2007
2312007
Plant “helper” immune receptors are Ca2+-permeable nonselective cation channels
P Jacob, NH Kim, F Wu, F El-Kasmi, Y Chi, WG Walton, OJ Furzer, ...
Science 373 (6553), 420-425, 2021
2292021
An atlas of β-glucuronidases in the human intestinal microbiome
RM Pollet, EH D'Agostino, WG Walton, Y Xu, MS Little, KA Biernat, ...
Structure 25 (7), 967-977. e5, 2017
2282017
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
EA Ortlund, Y Lee, IH Solomon, JM Hager, R Safi, Y Choi, Z Guan, ...
Nature structural & molecular biology 12 (4), 357-363, 2005
2242005
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