| HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease K Fujita, K Motoki, K Tagawa, X Chen, H Hama, K Nakajima, H Homma, ... Scientific reports 6 (1), 31895, 2016 | 136 | 2016 |
| Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation M Jin, H Shiwaku, H Tanaka, T Obita, S Ohuchi, Y Yoshioka, X Jin, ... Nature communications 12 (1), 6565, 2021 | 88 | 2021 |
| Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain K Tagawa, H Homma, A Saito, K Fujita, X Chen, S Imoto, T Oka, H Ito, ... Human molecular genetics 24 (2), 540-558, 2015 | 85 | 2015 |
| HMGB 1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin‐1 knock‐in mice H Ito, K Fujita, K Tagawa, X Chen, H Homma, T Sasabe, J Shimizu, ... EMBO molecular medicine 7 (1), 78-101, 2015 | 83 | 2015 |
| Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta X Chen, K Kondo, K Motoki, H Homma, H Okazawa Scientific reports 5 (1), 12115, 2015 | 81 | 2015 |
| YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology H Tanaka, H Homma, K Fujita, K Kondo, S Yamada, X Jin, M Waragai, ... Nature communications 11 (1), 507, 2020 | 70 | 2020 |
| Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology Y Mao, X Chen, M Xu, K Fujita, K Motoki, T Sasabe, H Homma, M Murata, ... Human molecular genetics 25 (21), 4749-4770, 2016 | 48 | 2016 |
| The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology H Tanaka, K Kondo, X Chen, H Homma, K Tagawa, A Kerever, S Aoki, ... Molecular psychiatry 23 (10), 2090-2110, 2018 | 47 | 2018 |
| In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells H Ito, H Shiwaku, C Yoshida, H Homma, H Luo, X Chen, K Fujita, ... Molecular psychiatry 20 (4), 459-471, 2015 | 38 | 2015 |
| Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology K Fujita, X Chen, H Homma, K Tagawa, M Amano, A Saito, S Imoto, ... Nature communications 9 (1), 433, 2018 | 30 | 2018 |
| RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair JB Taniguchi, K Kondo, K Fujita, X Chen, H Homma, T Sudo, Y Mao, ... Human Molecular Genetics 25 (20), 4432-4447, 2016 | 24 | 2016 |
| Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1 K Fujita, Y Mao, S Uchida, X Chen, H Shiwaku, T Tamura, H Ito, K Watase, ... Nature Communications 8 (1), 1864, 2017 | 16 | 2017 |
| HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology H Tanaka, K Kondo, K Fujita, H Homma, K Tagawa, X Jin, M Jin, ... Communications Biology 4 (1), 1175, 2021 | 15 | 2021 |
| The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing Y Mao, T Tamura, Y Yuki, D Abe, Y Tamada, S Imoto, H Tanaka, ... Cell Death & Disease 7 (4), e2207-e2207, 2016 | 14 | 2016 |
| Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries T Imamura, K Fujita, K Tagawa, T Ikura, X Chen, H Homma, T Tamura, ... Scientific reports 6 (1), 33861, 2016 | 11 | 2016 |
| HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease. Sci Rep 6: 31895 K Fujita, K Motoki, K Tagawa, X Chen, H Hama, K Nakajima, H Homma, ... | 7 | 2016 |
| Extraction Corresponding to the Impression H Homma, T Nakanishi, T Kitagawa Information Modelling and Knowledge Bases XVIII 15, 206, 2007 | 7 | 2007 |
| PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions X Jin, H Tanaka, M Jin, K Fujita, H Homma, M Inotsume, H Yong, ... Nature Communications 14 (1), 9, 2023 | 6 | 2023 |
| Hepta-histidine inhibits tau aggregation K Kondo, T Ikura, H Tanaka, K Fujita, S Takayama, Y Yoshioka, K Tagawa, ... ACS Chemical Neuroscience 12 (16), 3015-3027, 2021 | 6 | 2021 |
| DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis H Homma, H Tanaka, M Jin, X Jin, Y Huang, Y Yoshioka, CJF Bertens, ... Life science alliance 4 (7), 2021 | 6 | 2021 |
Kazuhiko TagawaAssociate Professor, Tokyo Medical and Dental University Dirección de correo verificada de mri.tmd.ac.jp
