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Raphael Franzini
Raphael Franzini
Associate Professor University of Utah
Dirección de correo verificada de utah.edu - Página principal
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DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries
RM Franzini, D Neri, J Scheuermann
Accounts of chemical research 47 (4), 1247-1255, 2014
2372014
Chemical space of DNA-encoded libraries: Miniperspective
RM Franzini, C Randolph
Journal of medicinal chemistry 59 (14), 6629-6644, 2016
2362016
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation
M Wichert, N Krall, W Decurtins, RM Franzini, F Pretto, P Schneider, ...
Nature chemistry 7 (3), 241-249, 2015
2002015
Efficient nucleic acid detection by templated reductive quencher release
RM Franzini, ET Kool
Journal of the American Chemical Society 131 (44), 16021-16023, 2009
1662009
Automated screening for small organic ligands using DNA-encoded chemical libraries
W Decurtins, M Wichert, RM Franzini, F Buller, MA Stravs, Y Zhang, D Neri, ...
Nature protocols 11 (4), 764-780, 2016
1192016
Bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of fluorophores and drugs in vivo
J Tu, M Xu, S Parvez, RT Peterson, RM Franzini
Journal of the American Chemical Society 140 (27), 8410-8414, 2018
1132018
Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library
RM Franzini, T Ekblad, N Zhong, M Wichert, W Decurtins, A Nauer, ...
Angewandte Chemie 127 (13), 3999-4003, 2015
1012015
Achievements, Challenges, and Opportunities in DNA‐Encoded Library Research: An Academic Point of View
LH Yuen, RM Franzini
ChemBioChem 18 (9), 829-836, 2017
912017
7‐Azidomethoxy‐coumarins as profluorophores for templated nucleic acid detection
RM Franzini, ET Kool
ChemBioChem 9 (18), 2981-2988, 2008
862008
A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes
LH Yuen, S Dana, Y Liu, SI Bloom, AG Thorsell, D Neri, AJ Donato, ...
Journal of the American Chemical Society 141 (13), 5169-5181, 2019
832019
Metal binding to bipyridine-modified PNA
RM Franzini, RM Watson, GK Patra, RM Breece, DL Tierney, MP Hendrich, ...
Inorganic chemistry 45 (24), 9798-9811, 2006
832006
Stable, reactive, and orthogonal tetrazines: dispersion forces promote the cycloaddition with isonitriles
J Tu, D Svatunek, S Parvez, AC Liu, BJ Levandowski, HJ Eckvahl, ...
Angewandte Chemie International Edition 58 (27), 9043-9048, 2019
782019
Mechanisms and substituent effects of metal-free bioorthogonal reactions
T Deb, J Tu, RM Franzini
Chemical reviews 121 (12), 6850-6914, 2021
772021
Pattern‐based detection of toxic metals in surface water with DNA polyfluorophores
LH Yuen, RM Franzini, S Wang, P Crisalli, V Singh, W Jiang, ET Kool
Angewandte Chemie International Edition 53 (21), 5361-5365, 2014
712014
Dissociative bioorthogonal reactions
J Tu, M Xu, RM Franzini
ChemBioChem 20 (13), 1615-1627, 2019
702019
Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries
RM Franzini, F Samain, M Abd Elrahman, G Mikutis, A Nauer, ...
Bioconjugate chemistry 25 (8), 1453-1461, 2014
702014
Tankyrase 1 inhibitors with drug-like properties identified by screening a DNA-encoded chemical library
F Samain, T Ekblad, G Mikutis, N Zhong, M Zimmermann, A Nauer, ...
Journal of medicinal chemistry 58 (12), 5143-5149, 2015
662015
Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives
M Xu, J Tu, RM Franzini
Chemical communications 53 (46), 6271-6274, 2017
632017
Large-scale detection of metals with a small set of fluorescent DNA-like chemosensors
LH Yuen, RM Franzini, SS Tan, ET Kool
Journal of the American Chemical Society 136 (41), 14576-14582, 2014
592014
Organometallic activation of a fluorogen for templated nucleic acid detection
RM Franzini, ET Kool
Organic letters 10 (14), 2935-2938, 2008
492008
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