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Zhiheng He
Zhiheng He
Wake Forest School of Medicine
Dirección de correo verificada de wakehealth.edu
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A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKɛ
D Liang, Y Gao, X Lin, Z He, Q Zhao, Q Deng, K Lan
Cell research 21 (5), 793-806, 2011
1552011
miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA
X Lin, D Liang, Z He, Q Deng, ES Robertson, K Lan
PloS one 6 (1), e16224, 2011
1512011
Latency-associated nuclear antigen of kaposi sarcoma–associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1
X Wang, Z He, T Xia, X Li, D Liang, X Lin, H Wen, K Lan
Cancer research 74 (7), 2026-2037, 2014
512014
A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development
Z He, J Ma, R Wang, J Zhang, Z Huang, F Wang, S Sen, EV Rothenberg, ...
Nature Immunology 18 (10), 1128-1138, 2017
452017
Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation
X Dong, Z He, D Durakoglugil, L Arneson, Y Shen, P Feng
Journal of virology 86 (4), 1930-1941, 2012
362012
SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner
S Sen, F Wang, J Zhang, Z He, J Ma, Y Gwack, J Xu, Z Sun
Proceedings of the National Academy of Sciences 115 (3), E458-E467, 2018
352018
Ubiquitination of RORγt at lysine 446 limits Th17 differentiation by controlling coactivator recruitment
Z He, F Wang, J Ma, S Sen, J Zhang, Y Gwack, Y Zhou, Z Sun
The Journal of Immunology 197 (4), 1148-1158, 2016
312016
Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis
D Liang, H Hu, S Li, J Dong, X Wang, Y Wang, L He, Z He, Y Gao, SJ Gao, ...
PLoS Pathogens 10 (7), e1004253, 2014
302014
Cellular corepressor TLE2 inhibits replication-and-transcription-activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus
Z He, Y Liu, D Liang, Z Wang, ES Robertson, K Lan
Journal of virology 84 (4), 2047-2062, 2010
302010
Inhibition of KSHV infected primary effusion lymphomas in NOD/SCID mice by γ-secretase inhibitor
K Lan, M Murakami, B Bajaj, R Kaul, Z He, R Gan, M Feldman, ...
Cancer biology & therapy 8 (22), 2136-2143, 2009
292009
PRMT1 plays a critical role in Th17 differentiation by regulating reciprocal recruitment of STAT3 and STAT5
S Sen, Z He, S Ghosh, KJ Dery, L Yang, J Zhang, Z Sun
The Journal of Immunology 201 (2), 440-450, 2018
252018
Regulation of Th17 differentiation by IKKα-dependent and-independent phosphorylation of RORγt
Z He, F Wang, J Zhang, S Sen, Q Pang, S Luo, Y Gwack, Z Sun
The Journal of Immunology 199 (3), 955-964, 2017
252017
Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
Z He, J Zhang, Z Huang, Q Du, N Li, Q Zhang, Y Chen, Z Sun
Nature Communications 9 (1), 4870, 2018
242018
Fine-tuning of the Kaposi’s sarcoma-associated herpesvirus life cycle in neighboring cells through the RTA-JAG1-Notch pathway
S Li, H Hu, Z He, D Liang, R Sun, K Lan
PLoS Pathogens 12 (10), e1005900, 2016
242016
TCF-1 inhibits IL-17 gene expression to restrain Th17 immunity in a stage-specific manner
J Zhang, Z He, S Sen, F Wang, Q Zhang, Z Sun
The Journal of Immunology 200 (10), 3397-3406, 2018
232018
NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus
Z He, J Zhao, J Zhang, JU Jung, P Feng
Journal of virology 88 (1), 444-455, 2014
222014
Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jκ and are responsible for LANA-mediated RTA repression
Y Jin, Z He, D Liang, Q Zhang, H Zhang, Q Deng, ES Robertson, K Lan
Journal of virology 86 (9), 4956-4969, 2012
222012
SRC3 is a cofactor for RORγt in Th17 differentiation but not thymocyte development
Z He, J Zhang, Q Du, J Xu, Y Gwack, Z Sun
The Journal of Immunology 202 (3), 760-769, 2019
162019
Decoupling the role of RORγt in the differentiation and effector function of TH17 cells
X Zhong, H Wu, W Zhang, Y Gwack, W Shang, KO Lee, N Isakov, Z He, ...
Science advances 8 (42), eadc9221, 2022
52022
Distinct inflammatory Th17 subsets emerge in autoimmunity and infection
RJ Bouch, J Zhang, BC Miller, CJ Robbins, TH Mosher, W Li, ...
Journal of Experimental Medicine 220 (10), e20221911, 2023
32023
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