JORGE CUELLAR
JORGE CUELLAR
Centro Nacional Biotecnología (CSIC), Universidad Autónoma de Madrid
Dirección de correo verificada de cnb.csic.es
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Structure of the Hsp110: Hsc70 nucleotide exchange machine
JP Schuermann, J Jiang, J Cuellar, O Llorca, L Wang, LE Gimenez, S Jin, ...
Molecular cell 31 (2), 232-243, 2008
2082008
The structure of CCT–Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin
J Cuéllar, J Martín-Benito, SHW Scheres, R Sousa, F Moro, ...
Nature structural & molecular biology 15 (8), 858-864, 2008
1002008
Modulation of the Hsp90 chaperone cycle by a stringent client protein
OR Lorenz, L Freiburger, DA Rutz, M Krause, BK Zierer, S Alvira, ...
Molecular cell 53 (6), 941-953, 2014
892014
Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop
S Alvira, J Cuéllar, A Röhl, S Yamamoto, H Itoh, C Alfonso, G Rivas, ...
Nature communications 5, 5484, 2014
842014
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity
AG Trinidad, PAJ Muller, J Cuellar, M Klejnot, M Nobis, JM Valpuesta, ...
Molecular cell 50 (6), 805-817, 2013
752013
PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates
PC Stirling, J Cuéllar, GA Alfaro, F El Khadali, CT Beh, JM Valpuesta, ...
Journal of Biological Chemistry 281 (11), 7012-7021, 2006
672006
Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
Á Peña, K Gewartowski, S Mroczek, J Cuéllar, A Szykowska, A Prokop, ...
The EMBO journal 31 (6), 1605-1616, 2012
642012
Dynamics, flexibility, and allostery in molecular chaperonins
L Skjærven, J Cuellar, A Martinez, JM Valpuesta
FEBS letters 589 (19), 2522-2532, 2015
512015
Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation
R Sousa, HS Liao, J Cuéllar, S Jin, JM Valpuesta, AJ Jin, EM Lafer
Nature structural & molecular biology 23 (9), 821-829, 2016
392016
Arc is a flexible modular protein capable of reversible self-oligomerization
C Myrum, A Baumann, HJ Bustad, MI Flydal, V Mariaule, S Alvira, ...
Biochemical Journal 468 (1), 145-158, 2015
362015
The architecture of the Schizosaccharomyces pombe CCR4-NOT complex
M Ukleja, J Cuellar, A Siwaszek, JM Kasprzak, M Czarnocki-Cieciura, ...
Nature communications 7, 10433, 2016
312016
Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding
CM Tracy, AJ Gray, J Cuéllar, TS Shaw, AC Howlett, RM Taylor, JT Prince, ...
Journal of Biological Chemistry 289 (7), 4490-4502, 2014
272014
Structures of the Gβ-CCT and PhLP1–Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly
RL Plimpton, J Cuéllar, CWJ Lai, T Aoba, A Makaju, S Franklin, AD Mathis, ...
Proceedings of the National Academy of Sciences 112 (8), 2413-2418, 2015
242015
Structural Insights into the Chaperone Activity of the 40-kDa Heat Shock Protein DnaJ BINDING AND REMODELING OF A NATIVE SUBSTRATE
J Cuéllar, J Perales-Calvo, A Muga, JM Valpuesta, F Moro
Journal of Biological Chemistry 288 (21), 15065-15074, 2013
232013
Structural analysis of the interactions between hsp70 chaperones and the yeast DNA replication protein Orc4p
M Moreno-del Álamo, A Sánchez-Gorostiaga, AM Serrano, A Prieto, ...
Journal of molecular biology 403 (1), 24-39, 2010
132010
The yeast THO complex forms a 5-subunit assembly that directly interacts with active chromatin
K Gewartowski, J Cuéllar, A Dziembowski, JM Valpuesta
Bioarchitecture 2 (4), 134-137, 2012
122012
Beyond the known functions of the CCR4‐NOT complex in gene expression regulatory mechanisms: new structural insights to unravel CCR4‐NOT mRNA processing machinery
M Ukleja, JM Valpuesta, A Dziembowski, J Cuellar
Bioessays 38 (10), 1048-1058, 2016
72016
Yeast mitochondrial RNAP conformational changes are regulated by interactions with the mitochondrial transcription factor
S Drakulic, L Wang, J Cuéllar, Q Guo, G Velázquez, J Martín-Benito, ...
Nucleic acids research 42 (17), 11246-11260, 2014
72014
Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins
J Cuellar, H Yébenes, SK Parker, G Carranza, M Serna, JM Valpuesta, ...
Biology open 3 (4), 261-270, 2014
52014
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
J Cuéllar, WG Ludlam, NC Tensmeyer, T Aoba, M Dhavale, C Santiago, ...
Nature communications 10 (1), 1-14, 2019
32019
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