| SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis M Ohashi, F Liu, Y Hai, M Chen, M Tang, Z Yang, M Sato, K Watanabe, ... Nature 549 (7673), 502-506, 2017 | 165 | 2017 |
| Enzymatic intermolecular hetero-Diels–Alder reaction in the biosynthesis of tropolonic sesquiterpenes Q Chen, J Gao, C Jamieson, J Liu, M Ohashi, J Bai, D Yan, B Liu, Y Che, ... Journal of the American Chemical Society 141 (36), 14052-14056, 2019 | 90 | 2019 |
| Enzyme-catalyzed inverse-electron demand Diels–Alder reaction in the biosynthesis of antifungal ilicicolin H Z Zhang, CS Jamieson, YL Zhao, D Li, M Ohashi, KN Houk, Y Tang Journal of the American Chemical Society 141 (14), 5659-5663, 2019 | 89 | 2019 |
| The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery CS Jamieson, M Ohashi, F Liu, Y Tang, KN Houk Natural product reports 36 (5), 698-713, 2019 | 87 | 2019 |
| Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind … N Kuwabara, T Oyama, D Tomioka, M Ohashi, J Yanagisawa, T Shimizu, ... Journal of medicinal chemistry 55 (2), 893-902, 2012 | 70 | 2012 |
| Genome-Mined Diels–Alderase Catalyzes Formation of the cis-Octahydrodecalins of Varicidin A and B D Tan, CS Jamieson, M Ohashi, MC Tang, KN Houk, Y Tang Journal of the American Chemical Society 141 (2), 769-773, 2019 | 65 | 2019 |
| Adipocytes as anticancer drug delivery depot D Wen, J Wang, G Van Den Driessche, Q Chen, Y Zhang, G Chen, H Li, ... Matter 1 (5), 1203-1214, 2019 | 56 | 2019 |
| Genome mining of alkaloidal terpenoids from a hybrid terpene and nonribosomal peptide biosynthetic pathway DA Yee, TB Kakule, W Cheng, M Chen, CTY Chong, Y Hai, LF Hang, ... Journal of the American Chemical Society 142 (2), 710-714, 2019 | 46 | 2019 |
| Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI Y Cai, Y Hai, M Ohashi, CS Jamieson, M Garcia-Borras, KN Houk, J Zhou, ... Nature chemistry 11 (9), 812-820, 2019 | 42 | 2019 |
| An enzymatic Alder-ene reaction M Ohashi, CS Jamieson, Y Cai, D Tan, D Kanayama, MC Tang, ... Nature 586 (7827), 64-69, 2020 | 41 | 2020 |
| Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility M Ohashi, T Oyama, EW Putranto, T Waku, H Nobusada, K Kataoka, ... Bioorganic & medicinal chemistry 21 (8), 2319-2332, 2013 | 35 | 2013 |
| Iterative catalysis in the biosynthesis of mitochondrial complex II inhibitors harzianopyridone and atpenin B U Bat-Erdene, D Kanayama, D Tan, WC Turner, KN Houk, M Ohashi, ... Journal of the American Chemical Society 142 (19), 8550-8554, 2020 | 34 | 2020 |
| Prospecting for natural products by genome mining and microcrystal electron diffraction LJ Kim, M Ohashi, Z Zhang, D Tan, M Asay, D Cascio, JA Rodriguez, ... Nature chemical biology 17 (8), 872-877, 2021 | 33 | 2021 |
| Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activated receptor γ (PPARγ)-selective antagonists based on the helix12-folding inhibition … M Ohashi, K Gamo, Y Tanaka, M Waki, Y Beniyama, K Matsuno, J Wada, ... European Journal of Medicinal Chemistry 90, 53-67, 2015 | 32 | 2015 |
| Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARγ-Selective Agonists: Discovery of Reversed Stereochemistry− Activity Relationship M Ohashi, T Oyama, I Nakagome, M Satoh, Y Nishio, H Nobusada, ... Journal of medicinal chemistry 54 (1), 331-341, 2011 | 32 | 2011 |
| Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining CY Chiang, M Ohashi, Y Tang Natural Product Reports 40 (1), 89-127, 2023 | 23 | 2023 |
| Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products M Ohashi, TB Kakule, MC Tang, CS Jamieson, M Liu, YL Zhao, KN Houk, ... Journal of the American Chemical Society 143 (15), 5605-5609, 2021 | 23 | 2021 |
| Peroxisome proliferator-activated receptor gamma (PPARγ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPARγ partial … M Ohashi, K Gamo, T Oyama, H Miyachi Bioorganic & Medicinal Chemistry Letters 25 (14), 2758-2762, 2015 | 20 | 2015 |
| Different structures of the two peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding domains in homodimeric complex with partial agonist, but not full agonist M Ohashi, T Oyama, H Miyachi Bioorganic & medicinal chemistry letters 25 (13), 2639-2644, 2015 | 20 | 2015 |
| Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry–activity relationship M Ohashi, I Nakagome, J Kasuga, H Nobusada, K Matsuno, M Makishima, ... Bioorganic & medicinal chemistry 20 (21), 6375-6383, 2012 | 19 | 2012 |
