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Chady H Hakim, PhD
Chady H Hakim, PhD
Principal Scientist
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Cited by
Cited by
Year
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
CE Nelson, CH Hakim, DG Ousterout, PI Thakore, EA Moreb, RMC Rivera, ...
Science 351 (6271), 403-407, 2016
13142016
Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy
JW McGreevy, CH Hakim, MA McIntosh, D Duan
Disease models & mechanisms 8 (3), 195-213, 2015
5102015
Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy
JH Shin, X Pan, CH Hakim, HT Yang, Y Yue, K Zhang, RL Terjung, ...
Molecular therapy 21 (4), 750-757, 2013
1492013
Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus
Y Yue, X Pan, CH Hakim, K Kodippili, K Zhang, JH Shin, HT Yang, ...
Human molecular genetics 24 (20), 5880-5890, 2015
1252015
Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin‐null mice
D Li, Y Yue, Y Lai, CH Hakim, D Duan
The Journal of pathology 223 (1), 88-98, 2011
1102011
A five-repeat micro-dystrophin gene ameliorated dystrophic phenotype in the severe DBA/2J-mdx model of Duchenne muscular dystrophy
CH Hakim, NB Wasala, X Pan, K Kodippili, Y Yue, K Zhang, G Yao, ...
Molecular Therapy-Methods & Clinical Development 6, 216-230, 2017
1042017
AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice
CH Hakim, NB Wasala, CE Nelson, LP Wasala, Y Yue, JA Louderman, ...
JCI insight 3 (23), 2018
942018
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice
CH Hakim, NB Wasala, D Duan
JoVE (Journal of Visualized Experiments), e50183, 2013
902013
Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of Duchenne muscular dystrophy
Y Zhang, Y Yue, L Li, CH Hakim, K Zhang, GD Thomas, D Duan
Human molecular genetics 22 (18), 3720-3729, 2013
852013
The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2-to 20-mo-old mdx mice
CH Hakim, RW Grange, D Duan
Journal of applied physiology 110 (6), 1656-1663, 2011
842011
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
CH Hakim, SRP Kumar, DO Pérez-López, NB Wasala, D Zhang, Y Yue, ...
Nature communications 12 (1), 6769, 2021
832021
Genotyping mdx, mdx3cv, and mdx4cv mice by primer competition polymerase chain reaction
JH Shin, CH Hakim, K Zhang, D Duan
Muscle & nerve 43 (2), 283-286, 2011
732011
Dual AAV Gene Therapy for Duchenne Muscular Dystrophy with a 7-kb Mini-Dystrophin Gene in the Canine Model
K Kodippili, CH Hakim, X Pan, HT Yang, Y Yue, Y Zhang, JH Shin, ...
Human gene therapy 29 (3), 299-311, 2018
702018
Monitoring murine skeletal muscle function for muscle gene therapy
CH Hakim, D Li, D Duan
Muscle Gene Therapy: Methods and Protocols, 75-89, 2011
702011
Connexin isoform expression in smooth muscle cells and endothelial cells of hamster cheek pouch arterioles and retractor feed arteries
CH Hakim, WF Jackson, SS Segal
Microcirculation 15 (6), 503-514, 2008
652008
Dystrophin contains multiple independent membrane-binding domains
J Zhao, K Kodippili, Y Yue, CH Hakim, L Wasala, X Pan, K Zhang, ...
Human molecular genetics 25 (17), 3647-3653, 2016
592016
AAV9 edits muscle stem cells in normal and dystrophic adult mice
ME Nance, R Shi, CH Hakim, NB Wasala, Y Yue, X Pan, T Zhang, ...
Molecular Therapy 27 (9), 1568-1585, 2019
582019
Gender differences in contractile and passive properties of mdx extensor digitorum longus muscle
CH Hakim, D Duan
Muscle & nerve 45 (2), 250-256, 2012
422012
Dystrophin deficiency compromises force production of the extensor carpi ulnaris muscle in the canine model of Duchenne muscular dystrophy
HT Yang, JH Shin, CH Hakim, X Pan, RL Terjung, D Duan
Public Library of Science 7 (9), e44438, 2012
352012
Nanotherapy for Duchenne muscular dystrophy
ME Nance, CH Hakim, NN Yang, D Duan
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 10 (2 …, 2018
342018
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Articles 1–20