|FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity|
PC Mahon, K Hirota, GL Semenza
Genes & development 15 (20), 2675-2686, 2001
|Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and …|
R Fukuda, K Hirota, F Fan, Y Do Jung, LM Ellis, GL Semenza
Journal of Biological Chemistry 277 (41), 38205-38211, 2002
|AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1|
K Hirota, M Matsui, S Iwata, A Nishiyama, K Mori, J Yodoi
Proceedings of the National Academy of Sciences 94 (8), 3633-3638, 1997
|Distinct roles of thioredoxin in the cytoplasm and in the nucleus a two-step mechanism of redox regulation of transcription factor NF-κB|
K Hirota, M Murata, Y Sachi, H Nakamura, J Takeuchi, K Mori, J Yodoi
Journal of Biological Chemistry 274 (39), 27891-27897, 1999
|Identification of thioredoxin-binding protein-2/vitamin D3 up-regulated protein 1 as a negative regulator of thioredoxin function and expression|
A Nishiyama, M Matsui, S Iwata, K Hirota, H Masutani, H Nakamura, ...
Journal of Biological Chemistry 274 (31), 21645-21650, 1999
|Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300|
M Ema, K Hirota, J Mimura, H Abe, J Yodoi, K Sogawa, L Poellinger, ...
The EMBO journal 18 (7), 1905-1914, 1999
|Cell type–specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia …|
BD Kelly, SF Hackett, K Hirota, Y Oshima, Z Cai, S Berg-Dixon, A Rowan, ...
Circulation research 93 (11), 1074-1081, 2003
|Regulation of angiogenesis by hypoxia-inducible factor 1|
K Hirota, GL Semenza
Critical reviews in oncology/hematology 59 (1), 15-26, 2006
|Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia|
SO Ang, H Chen, K Hirota, VR Gordeuk, J Jelinek, Y Guan, E Liu, ...
Nature genetics 32 (4), 614-621, 2002
|Thioredoxin-dependent redox regulation of p53-mediated p21 activation|
M Ueno, H Masutani, RJ Arai, A Yamauchi, K Hirota, T Sakai, T Inamoto, ...
Journal of Biological Chemistry 274 (50), 35809-35815, 1999
|Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling|
K Kasuno, S Takabuchi, K Fukuda, S Kizaka-Kondoh, J Yodoi, T Adachi, ...
Journal of Biological Chemistry 279 (4), 2550-2558, 2004
|Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases|
K Hirota, GL Semenza
Biochemical and biophysical research communications 338 (1), 610-616, 2005
|Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-κB in mammary epithelial cells and to quickly …|
W Yang, H Zerbe, W Petzl, RM Brunner, J Günther, C Draing, ...
Molecular immunology 45 (5), 1385-1397, 2008
|Redox control of resistance to cis-diamminedichloroplatinum (II)(CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.|
T Sasada, S Iwata, N Sato, Y Kitaoka, K Hirota, K Nakamura, A Nishiyama, ...
The Journal of clinical investigation 97 (10), 2268-2276, 1996
|Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation|
SJ Wei, A Botero, K Hirota, CM Bradbury, S Markovina, A Laszlo, DR Spitz, ...
Cancer research 60 (23), 6688-6695, 2000
|Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer|
T Hiraga, S Kizaka-Kondoh, K Hirota, M Hiraoka, T Yoneda
Cancer research 67 (9), 4157-4163, 2007
|Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-κB, AP-1, and CREB activation in HEK293 cells|
K Hirota, M Matsui, M Murata, Y Takashima, FS Cheng, T Itoh, K Fukuda, ...
Biochemical and biophysical research communications 274 (1), 177-182, 2000
|Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function|
Y Makino, N Yoshikawa, K Okamoto, K Hirota, J Yodoi, I Makino, ...
Journal of Biological Chemistry 274 (5), 3182-3188, 1999
|Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense …|
Y Makino, K Okamoto, N Yoshikawa, M Aoshima, K Hirota, J Yodoi, ...
The Journal of clinical investigation 98 (11), 2469-2477, 1996
|Rac1 activity is required for the activation of hypoxia-inducible factor 1|
K Hirota, GL Semenza
Journal of Biological Chemistry 276 (24), 21166-21172, 2001