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Joseph Cherian
Joseph Cherian
Associate Director, Medicinal Chemistry, Experimental Drug Development Centre
Dirección de correo verificada de eddc.sg
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Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
EJ Muñoz‐Elías, AM Upton, J Cherian, JD McKinney
Molecular microbiology 60 (5), 1109-1122, 2006
3982006
Selective killing of nonreplicating mycobacteria
R Bryk, B Gold, A Venugopal, J Singh, R Samy, K Pupek, H Cao, ...
Cell host & microbe 3 (3), 137-145, 2008
2122008
Probing cell-division phenotype space and Polo-like kinase function using small molecules
U Peters, J Cherian, JH Kim, BH Kwok, TM Kapoor
Nature chemical biology 2 (11), 618-626, 2006
1342006
A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis
PA Mak, SPS Rao, M Ping Tan, X Lin, J Chyba, J Tay, SH Ng, BH Tan, ...
ACS chemical biology 7 (7), 1190-1197, 2012
1332012
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824
SE Cellitti, J Shaffer, DH Jones, T Mukherjee, M Gurumurthy, B Bursulaya, ...
Structure 20 (1), 101-112, 2012
972012
Substrate specificity of the deazaflavin‐dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic …
M Gurumurthy, T Mukherjee, CS Dowd, R Singh, P Niyomrattanakit, ...
The FEBS journal 279 (1), 113-125, 2012
942012
Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-Nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3 …
J Cherian, I Choi, A Nayyar, UH Manjunatha, T Mukherjee, YS Lee, ...
Journal of medicinal chemistry 54 (16), 5639-5659, 2011
442011
Synthesis of the putative structure of eupomatilone-6
MK Gurjar, J Cherian, CV Ramana
Organic Letters 6 (3), 317-319, 2004
442004
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis
SB Lakshminarayana, HIM Boshoff, J Cherian, S Ravindran, A Goh, ...
PloS one 9 (8), e105222, 2014
262014
Synthesis of spirocycles via ring closing metathesis of heterocycles carrying gem-diallyl substituents obtained via ring opening of (halomethyl) cyclopropanes with allyltributyltin
MK Gurjar, SV Ravindranadh, K Sankar, S Karmakar, J Cherian, ...
Organic & biomolecular chemistry 1 (8), 1366-1373, 2003
252003
Fragment-based drug discovery of potent protein kinase C iota inhibitors
J Kwiatkowski, B Liu, DHY Tee, G Chen, NHB Ahmad, YX Wong, ZY Poh, ...
Journal of Medicinal Chemistry 61 (10), 4386-4396, 2018
222018
Studies toward unique mycolactone macrolides from Mycobacterium ulcerans
MK Gurjar, J Cherian
Heterocycles: an international journal for reviews and communications in …, 2001
202001
NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor
Y Li, YX Wong, ZY Poh, YL Wong, MY Lee, HQ Ng, B Liu, AW Hung, ...
FEBS letters 589 (19), 2683-2689, 2015
192015
Structure–activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells
J Cherian, K Nacro, ZY Poh, S Guo, DA Jeyaraj, YX Wong, M Ho, ...
Journal of Medicinal Chemistry 59 (7), 3063-3078, 2016
182016
Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy
Y Li, YL Wong, FM Ng, B Liu, YX Wong, ZY Poh, S Liu, SW Then, MY Lee, ...
Journal of Biological Chemistry 291 (34), 17743-17753, 2016
172016
Synthesis of benzonitriles from substituted benzaldehyde
MS Chorghade, MK Gurjar, J Cherian
US Patent 6,875,883, 2005
172005
Small molecules targeting the inactive form of the Mnk1/2 kinases
S Kannan, MR Pradhan, J Cherian, TL Joseph, ZY Poh, Y Hai Yan, ...
Acs Omega 2 (11), 7881-7891, 2017
152017
Synthesis of benzonitriles from substituted benzoic acid
MS Chorghade, MK Gurjar, J Cherian
US Patent 6,875,882, 2005
152005
Synthesis of 2-alkylcysteine
MS Chorghade, MK Gurjar, BM Chanda, J Cherian
US Patent 6,861,532, 2005
152005
Synthesis of benzimidate from benzoic acid
MS Chorghade, MK Gurjar, J Cherian
US Patent 6,846,958, 2005
152005
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Artículos 1–20