Leonidas Alexopoulos
Leonidas Alexopoulos
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Towards a rigorous assessment of systems biology models: the DREAM3 challenges
RJ Prill, D Marbach, J Saez-Rodriguez, PK Sorger, LG Alexopoulos, ...
PloS one 5 (2), e9202, 2010
The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage
F Guilak, LG Alexopoulos, ML Upton, I Youn, JB Choi, L Cao, LA Setton, ...
Annals of the New York Academy of Sciences 1068 (1), 498-512, 2006
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction
J Saez‐Rodriguez, LG Alexopoulos, J Epperlein, R Samaga, ...
Molecular systems biology 5 (1), 331, 2009
Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration
WR Trickey, FPT Baaijens, TA Laursen, LG Alexopoulos, F Guilak
Journal of biomechanics 39 (1), 78-87, 2006
The biomechanical role of the chondrocyte pericellular matrix in articular cartilage
LG Alexopoulos, LA Setton, F Guilak
Acta biomaterialia 1 (3), 317-325, 2005
Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis
LG Alexopoulos, MA Haider, TP Vail, F Guilak
J. Biomech. Eng. 125 (3), 323-333, 2003
Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage
LG Alexopoulos, GM Williams, ML Upton, LA Setton, F Guilak
Journal of biomechanics 38 (3), 509-517, 2005
The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data
R Samaga, J Saez-Rodriguez, LG Alexopoulos, PK Sorger, S Klamt
PLoS computational biology 5 (8), e1000438, 2009
Developmental and osteoarthritic changes in Col6a1‐knockout mice: Biomechanics of type VI collagen in the cartilage pericellular matrix
LG Alexopoulos, I Youn, P Bonaldo, F Guilak
Arthritis & Rheumatism: Official Journal of the American College of …, 2009
A deep learning framework for predicting response to therapy in cancer
T Sakellaropoulos, K Vougas, S Narang, F Koinis, A Kotsinas, A Polyzos, ...
Cell reports 29 (11), 3367-3373. e4, 2019
Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways
GR Erickson, LG Alexopoulos, F Guilak
Journal of biomechanics 34 (12), 1527-1535, 2001
Automated standardized pupillometry with optical method for purposes of clinical practice and research
F Fotiou, KN Fountoulakis, A Goulas, L Alexopoulos, A Palikaras
Clinical Physiology 20 (5), 336-347, 2000
Comparing signaling networks between normal and transformed hepatocytes using discrete logical models
J Saez-Rodriguez, LG Alexopoulos, MS Zhang, MK Morris, ...
Cancer research 71 (16), 5400-5411, 2011
Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data
A Mitsos, IN Melas, P Siminelakis, AD Chairakaki, J Saez-Rodriguez, ...
PLoS computational biology 5 (12), e1000591, 2009
Crowdsourcing network inference: the DREAM predictive signaling network challenge
RJ Prill, J Saez-Rodriguez, LG Alexopoulos, PK Sorger, G Stolovitzky
Science signaling 4 (189), mr7-mr7, 2011
Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
BD Cosgrove, BM King, MA Hasan, LG Alexopoulos, PA Farazi, ...
Toxicology and applied pharmacology 237 (3), 317-330, 2009
Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes
LG Alexopoulos, J Saez-Rodriguez, BD Cosgrove, DA Lauffenburger, ...
Molecular & Cellular Proteomics 9 (9), 1849-1865, 2010
Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization
F Guilak, LG Alexopoulos, MA Haider, HP Ting-Beall, LA Setton
Annals of biomedical engineering 33, 1312-1318, 2005
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining
K Vougas, T Sakellaropoulos, A Kotsinas, GRP Foukas, A Ntargaras, ...
Pharmacology & therapeutics 203, 107395, 2019
Verification of systems biology research in the age of collaborative competition
P Meyer, LG Alexopoulos, T Bonk, A Califano, CR Cho, A De La Fuente, ...
Nature biotechnology 29 (9), 811-815, 2011
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