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Peter Fekkes
Peter Fekkes
54gene, HotSpot Therapeutics, H3 Biomedicine, Novartis, UC San Diego, University of Groningen
Dirección de correo verificada de 54gene.com - Página principal
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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
YNP Chen, MJ LaMarche, HM Chan, P Fekkes, J Garcia-Fortanet, ...
Nature 535 (7610), 148-152, 2016
7752016
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ...
Nature cell biology 16 (11), 1069-1079, 2014
6482014
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ...
Nature medicine 24 (4), 497-504, 2018
4662018
Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point
RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ...
Cell reports 13 (5), 1033-1045, 2015
4492015
Protein targeting to the bacterial cytoplasmic membrane
P Fekkes, AJM Driessen
Microbiology and Molecular Biology Reviews 63 (1), 161-173, 1999
3711999
The molecular chaperone SecB is released from the carboxy‐terminus of SecA during initiation of precursor protein translocation
P Fekkes, C van der Does, AJM Driessen
The EMBO journal, 1997
2761997
Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor
J Garcia Fortanet, CHT Chen, YNP Chen, Z Chen, Z Deng, B Firestone, ...
Journal of medicinal chemistry 59 (17), 7773-7782, 2016
2592016
The sec system
AJM Driessen, P Fekkes, JPW van der Wolk
Current opinion in microbiology 1 (2), 216-222, 1998
2401998
Gag3p, an outer membrane protein required for fission of mitochondrial tubules
P Fekkes, KA Shepard, MP Yaffe
The Journal of cell biology 151 (2), 333-340, 2000
2172000
Preprotein transfer to the Escherichia coli translocase requires the co‐operative binding of SecB and the signal sequence to SecA
P Fekkes, JG De Wit, JPW Van Der Wolk, HH Kimsey, CA Kumamoto, ...
Molecular microbiology 29 (5), 1179-1190, 1998
1711998
Structural basis of splicing modulation by antitumor macrolide compounds
C Cretu, AA Agrawal, A Cook, CL Will, P Fekkes, PG Smith, R Lührmann, ...
Molecular cell 70 (2), 265-273. e8, 2018
1512018
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
T Teng, JHC Tsai, X Puyang, M Seiler, S Peng, S Prajapati, D Aird, ...
Nature communications 8 (1), 15522, 2017
1332017
PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA–SecY interaction during the initiation of translocation
JPW Van Der Wolk, P Fekkes, A Boorsma, JL Huie, TJ Silhavy, ...
The EMBO journal, 1998
1311998
Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer
MJ LaMarche, M Acker, A Argintaru, D Bauer, J Boisclair, H Chan, ...
Journal of medicinal chemistry 63 (22), 13578-13594, 2020
1292020
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer
M Korpal, X Puyang, Z Jeremy Wu, R Seiler, C Furman, HZ Oo, M Seiler, ...
Nature communications 8 (1), 103, 2017
1292017
H3B-6527 is a potent and selective inhibitor of FGFR4 in FGF19-driven hepatocellular carcinoma
JJ Joshi, H Coffey, E Corcoran, J Tsai, CL Huang, K Ichikawa, S Prajapati, ...
Cancer research 77 (24), 6999-7013, 2017
1262017
SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxyl terminus to the periplasm
C Van Der Does, T Den Blaauwen, JG De Wit, EH Manting, NA Groot, ...
Molecular microbiology 22 (4), 619-629, 1996
1261996
Zinc stabilizes the SecB binding site of SecA
P Fekkes, JG de Wit, A Boorsma, RHE Friesen, AJM Driessen
Biochemistry 38 (16), 5111-5116, 1999
1151999
Domain Interactions of the Peripheral Preprotein Translocase Subunit SecA
T den Blaauwen, P Fekkes, JG de Wit, W Kuiper, AJM Driessen
Biochemistry 35 (37), 11994-12004, 1996
1141996
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
LI Finci, X Zhang, X Huang, Q Zhou, J Tsai, T Teng, A Agrawal, B Chan, ...
Genes & development 32 (3-4), 309-320, 2018
1102018
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