Norman E. Sharpless
Norman E. Sharpless
Director, The National Cancer Institute
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Circular RNAs are abundant, conserved, and associated with ALU repeats
WR Jeck, JA Sorrentino, K Wang, MK Slevin, CE Burd, J Liu, WF Marzluff, ...
Rna 19 (2), 141-157, 2013
Genomic classification of cutaneous melanoma
R Akbani, KC Akdemir, BA Aksoy, M Albert, A Ally, SB Amin, H Arachchi, ...
Cell 161 (7), 1681-1696, 2015
Ink4a/Arf expression is a biomarker of aging
J Krishnamurthy, C Torrice, MR Ramsey, GI Kovalev, K Al-Regaiey, L Su, ...
The Journal of clinical investigation 114 (9), 1299-1307, 2004
Detecting and characterizing circular RNAs
WR Jeck, NE Sharpless
Nature biotechnology 32 (5), 453-461, 2014
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16 INK4a
V Janzen, R Forkert, HE Fleming, Y Saito, MT Waring, DM Dombkowski, ...
Nature 443 (7110), 421-426, 2006
The Regulation of INK4/ARF in Cancer and Aging
WY Kim, NE Sharpless
Cell 127 (2), 265-275, 2006
Increasing p16 INK4a expression decreases forebrain progenitors and neurogenesis during ageing
AV Molofsky, SG Slutsky, NM Joseph, S He, R Pardal, J Krishnamurthy, ...
Nature 443 (7110), 448-452, 2006
p16 INK4a induces an age-dependent decline in islet regenerative potential
J Krishnamurthy, MR Ramsey, KL Ligon, C Torrice, A Koh, S Bonner-Weir, ...
Nature 443 (7110), 453-457, 2006
How stem cells age and why this makes us grow old
NE Sharpless, RA DePinho
Nature reviews Molecular cell biology 8 (9), 703-713, 2007
LKB1 modulates lung cancer differentiation and metastasis
H Ji, MR Ramsey, DN Hayes, C Fan, K McNamara, P Kozlowski, C Torrice, ...
Nature 448 (7155), 807-810, 2007
Loss of p16 Ink4a with retention of p19 Arf predisposes mice to tumorigenesis
NE Sharpless, N Bardeesy, KH Lee, D Carrasco, DH Castrillon, ...
Nature 413 (6851), 86-91, 2001
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
CE Burd, WR Jeck, Y Liu, HK Sanoff, Z Wang, NE Sharpless
PLoS Genet 6 (12), e1001233, 2010
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
RM Bachoo, EA Maher, KL Ligon, NE Sharpless, SS Chan, MJ You, ...
Cancer cell 1 (3), 269-277, 2002
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
J Chang, Y Wang, L Shao, RM Laberge, M Demaria, J Campisi, ...
Nature medicine 22 (1), 78-83, 2016
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
The mighty mouse: genetically engineered mouse models in cancer drug development
NE Sharpless, RA DePinho
Nature reviews Drug discovery 5 (9), 741-754, 2006
The INK4A/ARF locus and its two gene products
NE Sharpless, RA DePinho
Current opinion in genetics & development 9 (1), 22-30, 1999
Telomeres, stem cells, senescence, and cancer
NE Sharpless, RA DePinho
The Journal of clinical investigation 113 (2), 160-168, 2004
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
KM Frank, NE Sharpless, Y Gao, JAM Sekiguchi, DO Ferguson, C Zhu, ...
Molecular cell 5 (6), 993-1002, 2000
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
H Ji, D Li, L Chen, T Shimamura, S Kobayashi, K McNamara, U Mahmood, ...
Cancer cell 9 (6), 485-495, 2006
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
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