| TLR signalling augments macrophage bactericidal activity through mitochondrial ROS AP West, IE Brodsky, C Rahner, DK Woo, H Erdjument-Bromage, ... Nature 472 (7344), 476-480, 2011 | 1640 | 2011 |
| Mitochondrial DNA stress primes the antiviral innate immune response AP West, W Khoury-Hanold, M Staron, MC Tal, S Pineda C, Lang, ... Nature 520 (7548), 533-537, 2015 | 1472 | 2015 |
| Mitochondria in innate immune responses AP West, GS Shadel, S Ghosh Nature Reviews Immunology 11 (6), 389-402, 2011 | 1409 | 2011 |
| Mitochondrial DNA maintenance in vertebrates GS Shadel, DA Clayton Annual review of biochemistry 66 (1), 409-435, 1997 | 1328 | 1997 |
| Mitochondrial ROS signaling in organismal homeostasis GS Shadel, TL Horvath Cell 163 (3), 560-569, 2015 | 1120 | 2015 |
| Mitochondrial DNA in innate immune responses and inflammatory pathology AP West, GS Shadel Nature Reviews Immunology 17 (6), 363-375, 2017 | 785 | 2017 |
| Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA A Rongvaux, R Jackson, CCD Harman, T Li, AP West, MR De Zoete, ... Cell 159 (7), 1563-1577, 2014 | 719 | 2014 |
| Replicative and chronological aging in Saccharomyces cerevisiae VD Longo, GS Shadel, M Kaeberlein, B Kennedy Cell metabolism 16 (1), 18-31, 2012 | 676 | 2012 |
| Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling MC Tal, M Sasai, HK Lee, B Yordy, GS Shadel, A Iwasaki Proceedings of the National Academy of Sciences 106 (8), 2770-2775, 2009 | 632 | 2009 |
| Interventions to slow aging in humans: are we ready? VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown‐Borg, C Caruso, ... Aging cell 14 (4), 497-510, 2015 | 603 | 2015 |
| SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2 Y Lei, J Zhang, CR Schiavon, M He, L Chen, H Shen, Y Zhang, Q Yin, ... Circulation research 128 (9), 1323-1326, 2021 | 540 | 2021 |
| Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression ND Bonawitz, M Chatenay-Lapointe, Y Pan, GS Shadel Cell metabolism 5 (4), 265-277, 2007 | 519 | 2007 |
| Initiation and beyond: multiple functions of the human mitochondrial transcription machinery ND Bonawitz, DA Clayton, GS Shadel Molecular cell 24 (6), 813-825, 2006 | 436 | 2006 |
| Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance HY Lee, CS Choi, AL Birkenfeld, TC Alves, FR Jornayvaz, MJ Jurczak, ... Cell metabolism 12 (6), 668-674, 2010 | 349 | 2010 |
| Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling Y Pan, EA Schroeder, A Ocampo, A Barrientos, GS Shadel Cell metabolism 13 (6), 668-678, 2011 | 348 | 2011 |
| Identification of the operator of the lux regulon from the Vibrio fischeri strain ATCC7744. JH Devine, GS Shadel, TO Baldwin Proceedings of the National Academy of Sciences 86 (15), 5688-5692, 1989 | 317 | 1989 |
| Revisiting the TCA cycle: signaling to tumor formation N Raimundo, BE Baysal, GS Shadel Trends in molecular medicine 17 (11), 641-649, 2011 | 277 | 2011 |
| A Human Mitochondrial Transcription Factor Is Related to RNA Adenine Methyltransferases and Binds S-Adenosylmethionine V McCulloch, BL Seidel-Rogol, GS Shadel Molecular and cellular biology 22 (4), 1116-1125, 2002 | 269 | 2002 |
| Mitochondrial transcription initiation. Variation and conservation GS Shadel, DA Clayton Journal of Biological Chemistry 268 (22), 16083-16086, 1993 | 247 | 1993 |
| Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator DJ Dairaghi, GS Shadel, DA Clayton Journal of molecular biology 249 (1), 11-28, 1995 | 244 | 1995 |
A. Phillip WestThe Jackson LaboratoryVerified email at jax.org
