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Xavier Rovira
Xavier Rovira
Institute for Advanced Chemistry of Catalonia (Iqac-csic)
Verified email at iqac.csic.es
Title
Cited by
Cited by
Year
Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
L Xue, X Rovira, P Scholler, H Zhao, J Liu, JP Pin, P Rondard
Nature chemical biology 11 (2), 134-140, 2015
1912015
An allosteric modulator to control endogenous G protein-coupled receptors with light
S Pittolo, X Gómez-Santacana, K Eckelt, X Rovira, J Dalton, C Goudet, ...
Nature chemical biology 10 (10), 813-815, 2014
1692014
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways
X Rovira, JP Pin, J Giraldo
Trends in pharmacological sciences 31 (1), 15-21, 2010
842010
OptoGluNAM4. 1, a photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity
X Rovira, A Trapero, S Pittolo, C Zussy, A Faucherre, C Jopling, J Giraldo, ...
Cell chemical biology 23 (8), 929-934, 2016
792016
Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
D Moreno Delgado, TC Møller, J Ster, J Giraldo, D Maurel, X Rovira, ...
Elife 6, e25233, 2017
772017
Illuminating phenylazopyridines to photoswitch metabotropic glutamate receptors: from the flask to the animals
X Gómez-Santacana, S Pittolo, X Rovira, M Lopez, C Zussy, JAR Dalton, ...
ACS central science 3 (1), 81-91, 2017
752017
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
P Scholler, D Nevoltris, D de Bundel, S Bossi, D Moreno-Delgado, ...
Nature Communications 8 (1), 1967, 2017
702017
Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors
X Rovira, F Malhaire, P Scholler, J Rodrigo, P Gonzalez‐Bulnes, ...
The FASEB Journal 29 (1), 116-130, 2015
642015
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, ...
Molecular psychiatry 23 (3), 509-520, 2018
632018
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
J Font, M Lopez-Cano, S Notartomaso, P Scarselli, P Di Pietro, ...
Elife 6, e23545, 2017
572017
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
J Liu, Z Zhang, D Moreno-Delgado, JAR Dalton, X Rovira, A Trapero, ...
Elife 6, e26985, 2017
562017
Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
L Xue, Q Sun, H Zhao, X Rovira, S Gai, Q He, JP Pin, J Liu, P Rondard
Nature communications 10 (1), 2765, 2019
522019
The catalytic power of enzymes: Conformational selection or transition state stabilization?
J Giraldo, D Roche, X Rovira, J Serra
FEBS letters 580 (9), 2170-2177, 2006
452006
Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice
S Marcos, C Monnier, X Rovira, C Fouveaut, N Pitteloud, F Ango, C Dodé, ...
Human molecular genetics 26 (11), 2006-2017, 2017
432017
Allosteric modulation of metabotropic glutamate receptors by chloride ions
AS Tora, X Rovira, I Dione, HO Bertrand, I Brabet, Y De Koninck, N Doyon, ...
The FASEB Journal 29 (10), 4174-4188, 2015
392015
FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor
N Lecat-Guillet, C Monnier, X Rovira, J Kniazeff, L Lamarque, JM Zwier, ...
Cell Chemical Biology 24 (3), 360-370, 2017
372017
Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited
J Giraldo, J Serra, D Roche, X Rovira
Current drug targets 8 (1), 197-202, 2007
302007
Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
AS Tora, X Rovira, AM Cao, A Cabayé, L Olofsson, F Malhaire, P Scholler, ...
Neuropharmacology 140, 275-286, 2018
282018
Modeling the binding and function of metabotropic glutamate receptors
X Rovira, D Roche, J Serra, J Kniazeff, JP Pin, J Giraldo
Journal of Pharmacology and Experimental Therapeutics 325 (2), 443-456, 2008
272008
Photoswitchable Antagonists for a Precise Spatiotemporal Control of β2-Adrenoceptors
A Duran-Corbera, J Catena, M Otero-Viñas, A Llebaria, X Rovira
Journal of Medicinal Chemistry 63 (15), 8458-8470, 2020
252020
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