| Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease L Dunn, GFG Allen, A Mamais, H Ling, A Li, KE Duberley, IP Hargreaves, ... Neurobiology of aging 35 (5), 1111-1115, 2014 | 217 | 2014 |
| Antarctic Dry Valley mineral soils contain unexpectedly high levels of microbial biomass DA Cowan, NJ Russell, A Mamais, DM Sheppard Extremophiles 6, 431-436, 2002 | 178 | 2002 |
| Inhibition of LRRK2 kinase activity stimulates macroautophagy C Manzoni, A Mamais, S Dihanich, R Abeti, MPM Soutar, H Plun-Favreau, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (12), 2900-2910, 2013 | 172 | 2013 |
| LRRK2 links genetic and sporadic Parkinson's disease JH Kluss, A Mamais, MR Cookson Biochemical Society Transactions 47 (2), 651-661, 2019 | 169 | 2019 |
| LRRK2 mediates tubulation and vesicle sorting from lysosomes L Bonet-Ponce, A Beilina, CD Williamson, E Lindberg, JH Kluss, ... Science advances 6 (46), eabb2454, 2020 | 150 | 2020 |
| Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7 R Chia, S Haddock, A Beilina, IN Rudenko, A Mamais, A Kaganovich, Y Li, ... Nature communications 5 (1), 5827, 2014 | 107 | 2014 |
| Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation C Manzoni, A Mamais, S Dihanich, P McGoldrick, MJ Devine, J Zerle, ... Biochemical and biophysical research communications 441 (4), 862-866, 2013 | 101 | 2013 |
| mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 C Manzoni, A Mamais, DA Roosen, S Dihanich, MPM Soutar, ... Scientific reports 6 (1), 35106, 2016 | 92 | 2016 |
| Regulation of V (D) J recombination by nucleosome positioning at recombination signal sequences M Baumann, A Mamais, F McBlane, H Xiao, J Boyes The EMBO Journal, 2003 | 88 | 2003 |
| Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies Z Ahmed, KM Doherty, L Silveira-Moriyama, R Bandopadhyay, T Lashley, ... Acta neuropathologica 122, 415-428, 2011 | 83 | 2011 |
| Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity JH Kluss, MM Conti, A Kaganovich, A Beilina, HL Melrose, MR Cookson, ... NPJ Parkinson's disease 4 (1), 13, 2018 | 68 | 2018 |
| A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity J Dusonchet, H Li, M Guillily, M Liu, K Stafa, C Derada Troletti, JY Boon, ... Human molecular genetics 23 (18), 4887-4905, 2014 | 68 | 2014 |
| Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory-and oxidative stress-related pathways upon treatment with α-synuclein fibrils I Russo, A Kaganovich, J Ding, N Landeck, A Mamais, T Varanita, A Biosa, ... Neurobiology of disease 129, 67-78, 2019 | 63 | 2019 |
| Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice L Pellegrini, DN Hauser, Y Li, A Mamais, A Beilina, R Kumaran, A Wetzel, ... Human molecular genetics 27 (18), 3257-3271, 2018 | 60 | 2018 |
| LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies C Kim, A Beilina, N Smith, Y Li, M Kim, R Kumaran, A Kaganovich, ... Science translational medicine 12 (565), eaay0399, 2020 | 59 | 2020 |
| The Parkinson’s disease protein LRRK2 interacts with the GARP complex to promote retrograde transport to the trans-Golgi network A Beilina, L Bonet-Ponce, R Kumaran, JJ Kordich, M Ishida, A Mamais, ... Cell reports 31 (5), 2020 | 59 | 2020 |
| Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases A Mamais, M Raja, C Manzoni, S Dihanich, A Lees, D Moore, PA Lewis, ... Neurobiology of disease 58, 183-190, 2013 | 57 | 2013 |
| Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus D Trabzuni, M Ryten, W Emmett, A Ramasamy, KJ Lackner, T Zeller, ... PloS one 8 (8), e70724, 2013 | 55 | 2013 |
| Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution A Mamais, R Chia, A Beilina, DN Hauser, C Hall, PA Lewis, MR Cookson, ... Journal of Biological Chemistry 289 (31), 21386-21400, 2014 | 54 | 2014 |
| Hexokinases link DJ-1 to the PINK1/parkin pathway DN Hauser, A Mamais, MM Conti, CT Primiani, R Kumaran, AA Dillman, ... Molecular neurodegeneration 12, 1-17, 2017 | 53 | 2017 |
Mark CooksonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthVerified email at mail.nih.gov
