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MANUEL SALDIVIA
MANUEL SALDIVIA
Principal Scientist II
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The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing
R Diaz-Gonzalez, FM Kuhlmann, C Galan-Rodriguez, LM da Silva, ...
PLoS neglected tropical diseases 5 (8), e1297, 2011
922011
Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei
A Barquilla, M Saldivia, R Diaz, JM Bart, I Vidal, E Calvo, MN Hall, ...
Proceedings of the National Academy of Sciences 109 (36), 14399-14404, 2012
842012
The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria‐mediated apoptosis and DNA damage in p53 mutant leukemic T cells
MJ Ruiz‐Magaña, JM Rodríguez‐Vargas, JC Morales, MA Saldivia, ...
International journal of cancer 130 (5), 1195-1207, 2012
612012
The AMPKα1 pathway positively regulates the developmental transition from proliferation to quiescence in Trypanosoma brucei
M Saldivia, G Ceballos-Pérez, JM Bart, M Navarro
Cell reports 17 (3), 660-670, 2016
582016
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
M Saldivia, E Fang, X Ma, E Myburgh, JBT Carnielli, C Bower-Lepts, ...
Nature microbiology 5 (10), 1207-1216, 2020
482020
Establishment of a Structure–Activity Relationship of 1H-Imidazo[4,5-c]quinoline-Based Kinase Inhibitor NVP-BEZ235 as a Lead for African Sleeping Sickness
JD Seixas, SA Luengo-Arratta, R Diaz, M Saldivia, DI Rojas-Barros, ...
Journal of medicinal chemistry 57 (11), 4834-4848, 2014
392014
Target of rapamycin (TOR) kinase in Trypanosoma brucei: an extended family
M Saldivia, A Barquilla, JM Bart, R Diaz-González, MN Hall, M Navarro
Biochemical Society transactions 41 (4), 934-938, 2013
312013
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
SPS Rao, MK Gould, J Noeske, M Saldivia, RS Jumani, PS Ng, O René, ...
Science 380 (6652), 1349-1356, 2023
102023
A CLK1-KKT2 signaling pathway regulating kinetochore assembly in Trypanosoma brucei
M Saldivia, AJM Wollman, JBT Carnielli, NG Jones, MC Leake, ...
MBio 12 (3), 10.1128/mbio. 00687-21, 2021
82021
CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics
V Geoghegan, JBT Carnielli, NG Jones, M Saldivia, S Antoniou, ...
Communications biology 5 (1), 1305, 2022
22022
Concentración espermática mínima requerida para inseminación intrauterina mediante capacitación por migración ascendente
R Lozano-Hernández, M Saldivia, A Villavicencio
Revista de Obstetricia y Ginecología de Venezuela 74 (3), 177-183, 2014
22014
A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas’ disease
M Saldivia, APCA Lima, JC Mottram
Trends in Parasitology, 2024
2024
Hollow fibre infection model for investigating the long-term culture of trypanosome parasites and their response to therapy
R Sterritt, S Lakshminarayana, M Saldivia, D Patra, S Rao, C Osborne
BRITISH JOURNAL OF PHARMACOLOGY 177 (11), 2613-2614, 2020
2020
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