Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin CJ Mycroft-West, D Su, I Pagani, TR Rudd, S Elli, NS Gandhi, ... Thrombosis and haemostasis 120 (12), 1700-1715, 2020 | 506* | 2020 |
Heparan sulfate and heparin interactions with proteins MCZ Meneghetti, AJ Hughes, TR Rudd, HB Nader, AK Powell, EA Yates, ... Journal of the Royal Society Interface 12 (110), 20150589, 2015 | 285 | 2015 |
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells S Ghezzi, L Cooper, A Rubio, I Pagani, MR Capobianchi, G Ippolito, ... Antiviral research 140, 13-17, 2017 | 101 | 2017 |
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations JA Tree, JE Turnbull, KR Buttigieg, MJ Elmore, N Coombes, J Hogwood, ... British Journal of Pharmacology 178 (3), 626-635, 2021 | 95 | 2021 |
Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp AS Brito, DS Arimatéia, LR Souza, MA Lima, VO Santos, VP Medeiros, ... Bioorganic & medicinal chemistry 16 (21), 9588-9595, 2008 | 90 | 2008 |
New applications of heparin and other glycosaminoglycans M Lima, T Rudd, E Yates Molecules 22 (5), 749, 2017 | 87 | 2017 |
Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction SE Guimond, CJ Mycroft-West, NS Gandhi, JA Tree, TT Le, CM Spalluto, ... ACS central science 8 (5), 527-545, 2022 | 83* | 2022 |
Atomic details of the interactions of glycosaminoglycans with amyloid-β fibrils KL Stewart, E Hughes, EA Yates, GR Akien, TY Huang, MA Lima, ... Journal of the American Chemical Society 138 (27), 8328-8331, 2016 | 52 | 2016 |
A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential AS Brito, RS Cavalcante, LCGF Palhares, AJ Hughes, GPV Andrade, ... Carbohydrate polymers 99, 372-378, 2014 | 49 | 2014 |
Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain ZP Schuurs, E Hammond, S Elli, TR Rudd, CJ Mycroft-West, MA Lima, ... Computational and Structural Biotechnology Journal 19, 2806-2818, 2021 | 43 | 2021 |
A heparin mimetic isolated from a marine shrimp suppresses neovascularization JL Dreyfuss, CV Regatieri, MA Lima, EJ Paredes‐gamero, AS Brito, ... Journal of Thrombosis and Haemostasis 8 (8), 1828-1837, 2010 | 43 | 2010 |
The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models SP Davies, CJ Mycroft-West, I Pagani, HJ Hill, YH Chen, R Karlsson, ... Frontiers in Pharmacology 12, 660490, 2021 | 42 | 2021 |
Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan RP Cavalheiro, MA Lima, TR Jarrouge-Bouças, GM Viana, CC Lopes, ... Matrix Biology 63, 23-37, 2017 | 42 | 2017 |
SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells CM Vicente, MA Lima, HB Nader, L Toma Journal of Experimental & Clinical Cancer Research 34, 1-16, 2015 | 40 | 2015 |
A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence SF Chavante, AS Brito, M Lima, E Yates, H Nader, M Guerrini, G Torri, ... Carbohydrate research 390, 59-66, 2014 | 39 | 2014 |
A heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activity GPV Andrade, MA Lima, AA de Souza Junior, J Fareed, DA Hoppensteadt, ... Carbohydrate polymers 94 (1), 647-654, 2013 | 39 | 2013 |
A new approach for heparin standardization: Combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis MA Lima, TR Rudd, EHC de Farias, LF Ebner, TF Gesteira, LM de Souza, ... PLoS One 6 (1), e15970, 2011 | 37 | 2011 |
Lepstospira interrogans shotgun phage display identified LigB as a heparin-binding protein ATC Ching, RD Fávaro, SS Lima, AAM Chaves, MA de Lima, HB Nader, ... Biochemical and biophysical research communications 427 (4), 774-779, 2012 | 33 | 2012 |
Active site mapping of Loxosceles phospholipases D: Biochemical and biological features L Vuitika, D Chaves-Moreira, I Caruso, MA Lima, FH Matsubara, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016 | 32 | 2016 |
Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases CM Vicente, MA Lima, EA Yates, HB Nader, L Toma Molecular Cancer Research 13 (3), 510-523, 2015 | 31 | 2015 |