| In vitro generation of infectious scrapie prions J Castilla, P Saá, C Hetz, C Soto Cell 121 (2), 195-206, 2005 | 1009 | 2005 |
| Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein C Hetz, M Russelakis‐Carneiro, K Maundrell, J Castilla, C Soto The EMBO journal, 2003 | 484 | 2003 |
| Production of cattle lacking prion protein JA Richt, P Kasinathan, AN Hamir, J Castilla, T Sathiyaseelan, F Vargas, ... Nature biotechnology 25 (1), 132-138, 2007 | 442 | 2007 |
| Detection of prions in blood J Castilla, P Saá, C Soto Nature medicine 11 (9), 982-985, 2005 | 432 | 2005 |
| Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification P Saá, J Castilla, C Soto Journal of Biological Chemistry 281 (46), 35245-35252, 2006 | 380 | 2006 |
| Amyloids, prions and the inherent infectious nature of misfolded protein aggregates C Soto, L Estrada, J Castilla Trends in biochemical sciences 31 (3), 150-155, 2006 | 336 | 2006 |
| Presymptomatic detection of prions in blood P Saá, J Castilla, C Soto Science 313 (5783), 92-94, 2006 | 309 | 2006 |
| The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity C Hetz, M Russelakis-Carneiro, S Wälchli, S Carboni, E Vial-Knecht, ... Journal of Neuroscience 25 (11), 2793-2802, 2005 | 257 | 2005 |
| Prion strain mutation determined by prion protein conformational compatibility and primary structure RC Angers, HE Kang, D Napier, S Browning, T Seward, C Mathiason, ... Science 328 (5982), 1154-1158, 2010 | 253 | 2010 |
| De novo induction of amyloid-β deposition in vivo R Morales, C Duran-Aniotz, J Castilla, LD Estrada, C Soto Molecular psychiatry 17 (12), 1347-1353, 2012 | 239 | 2012 |
| Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality J Kumar, H Eraña, E López-Martínez, N Claes, VF Martín, DM Solís, ... Proceedings of the National Academy of Sciences 115 (13), 3225-3230, 2018 | 231 | 2018 |
| Crossing the species barrier by PrPSc replication in vitro generates unique infectious prions J Castilla, D Gonzalez-Romero, P Saá, R Morales, J De Castro, C Soto Cell 134 (5), 757-768, 2008 | 230 | 2008 |
| Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases R Morales, LD Estrada, R Diaz-Espinoza, D Morales-Scheihing, MC Jara, ... Journal of Neuroscience 30 (13), 4528-4535, 2010 | 228 | 2010 |
| Cell‐free propagation of prion strains J Castilla, R Morales, P Saá, M Barria, P Gambetti, C Soto The EMBO journal 27 (19), 2557-2566, 2008 | 220 | 2008 |
| Pre-symptomatic detection of prions by cyclic amplification of protein misfolding C Soto, L Anderes, S Suardi, F Cardone, J Castilla, MJ Frossard, S Peano, ... FEBS letters 579 (3), 638-642, 2005 | 195 | 2005 |
| Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis C Hetz, AH Lee, D Gonzalez-Romero, P Thielen, J Castilla, C Soto, ... Proceedings of the National Academy of Sciences 105 (2), 757-762, 2008 | 186 | 2008 |
| Protein misfolding cyclic amplification for diagnosis and prion propagation studies J Castilla, P Saá, R Morales, K Abid, K Maundrell, C Soto Methods in enzymology 412, 3-21, 2006 | 186 | 2006 |
| Isolation and Characterization of a Proteinase K-Sensitive PrPSc Fraction MA Pastrana, G Sajnani, B Onisko, J Castilla, R Morales, C Soto, ... Biochemistry 45 (51), 15710-15717, 2006 | 182 | 2006 |
| A molecular switch controls interspecies prion disease transmission in mice CJ Sigurdson, KPR Nilsson, S Hornemann, G Manco, ... The Journal of clinical investigation 120 (7), 2590-2599, 2010 | 167 | 2010 |
| The controversial protein-only hypothesis of prion propagation C Soto, J Castilla Nature medicine 10 (Suppl 7), S63-S67, 2004 | 157 | 2004 |
