Lance Munn
Lance Munn
Harvard Medical School
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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
CG Willett, Y Boucher, E Di Tomaso, DG Duda, LL Munn, RT Tong, ...
Nature medicine 10 (2), 145-147, 2004
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
F Winkler, SV Kozin, RT Tong, SS Chae, MF Booth, I Garkavtsev, L Xu, ...
Cancer cell 6 (6), 553-563, 2004
Normalization of the vasculature for treatment of cancer and other diseases
S Goel, DG Duda, L Xu, LL Munn, Y Boucher, D Fukumura, RK Jain
Physiological reviews 91 (3), 1071-1121, 2011
Lymphatic metastasis in the absence of functional intratumor lymphatics
TP Padera, A Kadambi, E di Tomaso, CM Carreira, EB Brown, Y Boucher, ...
Science 296 (5574), 1883-1886, 2002
Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood
YS Chang, E di Tomaso, DM McDonald, R Jones, RK Jain, LL Munn
Proceedings of the National Academy of Sciences 97 (26), 14608-14613, 2000
Dissecting tumour pathophysiology using intravital microscopy
RK Jain, LL Munn, D Fukumura
Nature Reviews Cancer 2 (4), 266-276, 2002
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
BJ Vakoc, RM Lanning, JA Tyrrell, TP Padera, LA Bartlett, ...
Nature medicine 15 (10), 1219-1223, 2009
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
Y Huang, J Yuan, E Righi, WS Kamoun, M Ancukiewicz, J Nezivar, ...
Proceedings of the National Academy of Sciences 109 (43), 17561-17566, 2012
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
RK Jain, RT Tong, LL Munn
Cancer research 67 (6), 2729-2735, 2007
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
T Stylianopoulos, JD Martin, VP Chauhan, SR Jain, B Diop-Frimpong, ...
Proceedings of the National Academy of Sciences 109 (38), 15101-15108, 2012
During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
RJ Melder, GC Koenig, BP Witwer, N Safabakhsh, LL Munn, RK Jain
Nature medicine 2 (9), 992-997, 1996
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal …
CG Willett, Y Boucher, DG Duda, E Di Tomaso, LL Munn, RT Tong, ...
Journal of Clinical Oncology 23 (31), 8136-8139, 2005
Mechanical compression drives cancer cells toward invasive phenotype
MT Janet, G Cheng, JA Tyrrell, SA Wilcox-Adelman, Y Boucher, RK Jain, ...
Proceedings of the National Academy of Sciences 109 (3), 911-916, 2012
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre‐clinical models
DAI Fukumura, DG Duda, LL Munn, RK Jain
Microcirculation 17 (3), 206-225, 2010
Fluid forces control endothelial sprouting
JW Song, LL Munn
Proceedings of the National Academy of Sciences 108 (37), 15342-15347, 2011
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
RB Campbell, D Fukumura, EB Brown, LM Mazzola, Y Izumi, RK Jain, ...
Cancer research 62 (23), 6831-6836, 2002
Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells
G Cheng, J Tse, RK Jain, LL Munn
PLoS one 4 (2), e4632, 2009
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis
S Patan, LL Munn, RK Jain
Microvascular research 51 (2), 260-272, 1996
Modeling the flow of dense suspensions of deformable particles in three dimensions
MM Dupin, I Halliday, CM Care, L Alboul, LL Munn
Physical Review E 75 (6), 066707, 2007
Solid stress generated by spheroid growth estimated using a linear poroelasticity model☆
T Roose, PA Netti, LL Munn, Y Boucher, RK Jain
Microvascular research 66 (3), 204-212, 2003
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